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Neck surgery showdown: which disc implant works best?

NCT ID NCT05701059

Disease control Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will measure neck movement, pain, and quality of life before surgery and at 3, 6, and 12 months after to see which implant performs better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
artificial disc implants (Biomet Zimmer Mobi-C and Nuvasive Simplify)
What this could lead to
If this trial succeeds, it could help surgeons choose the best disc implant for neck surgery, leading to better pain relief and neck movement for patients.
What could go wrong
This is a small early study with only 20 people, so results may not apply to everyone. Both implants are already FDA-approved, so no major new treatment is being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects must be experiencing cervical spondylotic myelopathy and/or radiculopathy typically caused by disc herniation or degenerative disc disease at a single level between C3 to C7 after being unresponsive to at least six weeks of non-surgical conservative care. This study is for patients who have the intention of undergoing cervical arthroplasty and have already been recommended to do so by a doctor.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient is skeletally mature and between 18 to 60 years of age * Experiences cervical spondylotic myelopathy and/or radiculopathy typically caused by disc herniation or degenerative disc disease at a single level between C3 to C7 * Is unresponsive to at least six weeks of non-surgical conservative care * Has the intention of undergoing cervical arthroplasty for their chief complaint * Signed informed consent form Exclusion Criteria: * Patient has had prior cervical spine surgery * Has more than two diseased levels requiring surgery * Has a known allergy to a metal alloy or polyethylene * Is morbidly obese * Has active local or system infection * Has any circumstances or conditions such that their ability to provide informed consent comply with follow-up requirements, or provide self-assessments is compromised (eg: psychiatric disorders, chronic alcohol or substance abuse, etc.)

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Conditions

The condition(s) this trial relates to.

Intervertebral Disc Displacement intervertebral disk degenerative disorder lumbar disk degenerative disorder radiculopathy spinal cord disorder spondylosis spondylosis, cervical

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical disc herniation Cervical radiculopathy Cervical spondylosis with myelopathy Degenerative disc disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UCLA

    RECRUITING

    Los Angeles, California, 90095, United States

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Other studies related to the condition(s) this trial covers.