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Ice and cold saline may ease pain after root canal or pulp treatment

NCT ID NCT06183021

Symptom relief Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying cryotherapy (ice or cold saline) during dental procedures for deep cavities reduces pain and improves quality of life. 144 adults received either a pulpotomy or root canal treatment, with or without cryotherapy. The goal was to see if the cold treatment helps with pain, healing, and overall success.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryotherapy (ice and cold saline)
What this could lead to
If it works, this could offer a simple, low-cost way to reduce pain and improve healing after dental procedures for deep cavities.
What could go wrong
This is a small, completed trial with no phase designation, so results may not apply broadly. The effect may be modest or not clinically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

144 people

The number who actually took part.

Started

Dec 2023

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being in the age range of 18-65. * Having an upper or lower jaw molar with deep dentin caries. * No previous restorations, root canal treatments, fractures, or cracks in the relevant tooth. * Loss of substance in the relevant tooth is limited to a Class I type, involving only the occlusal surface of the tooth. * Obtaining a negative response to palpation and percussion. * Normal periodontal tissues (pocket depth less than 3 mm and normal mobility). * Exposing the pulp when the caries is completely cleaned Exclusion Criteria: * Having a chronic systemic disease that impedes local anaesthesia and the application of endodontic procedures. * Presence of cracks, fractures, or restorations in the relevant tooth. * Raynaud's phenomenon. * Partial or total necrosis in the relevant tooth. * Teeth with cavities other than Class I, involving more than one surface of substance loss in the relevant tooth. * Teeth diagnosed with acute apical abscess or chronic apical abscess. * Pregnant or breastfeeding women. * History of allergy to materials and drugs used in treatment. * Patients reporting spontaneous pain with a Visual Analog Scale (VAS) score of 5 or above and provoked pain lasting over 20 seconds during examination. * Positive response to percussion and palpation. * Advanced periodontal disease (Pocket depth greater than 3 mm and Class I or higher mobility). * Pulp not exposed when caries is cleaned (not emerging, covered with intact dentin). * The root apex of the relevant tooth being immature

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Conditions

The condition(s) this trial relates to.

dentin caries Pain, Postoperative pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries; dentin Pain, postoperative Pulpitis

Contacts and locations

Locations

  • Ondokuz Mayıs University Dp. Endodontics, Faculty of Dentistry

    Samsun, Samsun, 55400, Turkey (Türkiye)

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