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New pain block could reduce opioid use after lung surgery

NCT ID NCT04864210

Symptom relief Sponsor: Nada Sadek Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two ways to manage pain after video-assisted lung surgery: an intercostal nerve block using liposomal bupivacaine and a paravertebral block using plain bupivacaine. 176 adults undergoing VATS were enrolled. The main goal was to see how many patients needed opioid painkillers in the first 48 hours after surgery. The results could help doctors choose the best pain relief method to reduce opioid use and improve recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liposomal bupivacaine and plain bupivacaine
What this could lead to
If one method works better, it could lead to better pain control and less opioid use after lung surgery.
What could go wrong
This is a small, completed Phase 2 trial, so results may not apply to all patients. The liposomal bupivacaine is not FDA-approved for this use, and individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

176 people

The number who actually took part.

Started

Feb 2021

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age over 18 years and less than 80 years * Undergoing video-assisted thoracoscopic surgery (VATS) procedure * BMI less than 40 Exclusion Criteria: * Unable to provide informed consent * Non-English speaking * Pregnant * BMI greater than 40 * Video-assisted thoracoscopic surgery pleurodesis subjects * Patients with pre-existing chronic pain * Opioid tolerance * Pain syndromes including fibromyalgia, regional pain syndrome or post therapeutic neuralgia in a thoracic distribution * Allergy to the study medication * Patients with infectious disease * Patients with impaired coagulation * Severe hepatic disease * Incarcerated

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain, postoperative

Contacts and locations

Locations

  • University of Iowa

    Iowa City, Iowa, 52242, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.