Which nerve block works best for post-surgery chest pain?
NCT ID NCT04222010
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested three different nerve block techniques to control pain after thoracoscopic (chest) surgery. 155 adults were randomly assigned to receive either a serratus plane block, a paravertebral block, or both together, using the anesthetic ropivacaine. The goal was to find which method provides the best pain relief and could help prevent long-term pain.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ropivacaine (a local anesthetic)
- What this could lead to
- If successful, this study could identify the best nerve block technique to reduce pain after chest surgery, leading to faster recovery and less chronic pain.
- What could go wrong
- This is a completed Phase 3 trial with 155 participants, so results are fairly reliable. However, individual responses to pain relief vary, and the best technique may still not eliminate pain for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
155 people
The number who actually took part.
- Started
-
Jan 2020
- Finished
-
Feb 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * adult patient over18 years old * without guardianship * video-assisted thoracoscopic surgery with 3 trocars * No cons-indications to loco-regional anesthesia (allergy, skin condition) Exclusion Criteria: * patient under 18 years old * patient under guardianship * pregnant * rejection of consent * rejection of loco-regional anesthesia * chronic pain antecedents under morphine medication * pain assessment impossible
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Amiens
Amiens, 80054, France
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