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New long-lasting painkiller may cut opioid use after foot surgery

NCT ID NCT05494645

Symptom relief Sponsor: St. Luke's Hospital, Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a long-acting painkiller called Exparel (liposomal bupivacaine) works better than the standard version for numbing the foot and ankle during and after surgery. About 248 adults having elective foot or ankle surgery received either Exparel or standard bupivacaine in a nerve block. Researchers measured how long the block lasted and how many opioid pain pills patients needed by day four after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exparel (liposomal bupivacaine)
What this could lead to
If it works, this could mean better pain control and less need for opioid pills after foot or ankle surgery.
What could go wrong
This is a single-center Phase 4 trial with 248 participants, so results may not apply to all patients or surgeries. The benefit over standard bupivacaine may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

248 people

The number who actually took part.

Started

Mar 2022

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients undergoing elective orthopaedic foot and ankle surgery at a single institution * English speaking * Able to provide consent to surgery and study participation Exclusion Criteria: * Non-elective or emergent foot and ankle surgery * Non-english speaking * Does not possess medical decision making capacity

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Conditions

The condition(s) this trial relates to.

Ankle Fractures ankle injury disease Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle fractures Ankle injuries and disorders Pain, acute postoperative Pain, postoperative

Contacts and locations

Locations

  • St. Luke's University Health Network

    Bethlehem, Pennsylvania, 18015, United States

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