University Of Pennsylvania

This study tests a two-drug immunotherapy (odetiglucan and mitazalimab) as a maintenance treatment for people with advanced pancreatic cancer that has not worsened after initial chemotherapy. The goal is to see if this combination can delay cancer growth for at least 7.5 months. …

This study looks at whether using a Foley catheter to prepare the cervix for labor can be done safely at home instead of in the hospital for first-time mothers. About 2,300 women will be randomly assigned to either outpatient or inpatient care. The goal is to see if the outpatien…

This study looks at whether a program pairing group self-management classes with one-on-one help from community health workers can improve heart health for 500 Philadelphia residents aged 35-75 who have conditions like diabetes or high blood pressure and face challenges like unst…

This study looks at whether older adults (65+) with hypothyroidism can safely take their thyroid medication (levothyroxine) with more flexible dosing. About 228 participants will be followed to see how this affects their quality of life, tiredness, and thinking abilities. The goa…

This early-phase trial tests a new treatment for people with a specific type of recurrent glioblastoma, an aggressive brain cancer. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack the cancer. Participants will receive these c…

This study tests whether adding personalized medicine (based on genes) and extra support to take medication correctly can help smokers with HIV quit smoking more effectively. About 340 adults with HIV who smoke daily will receive either varenicline or a nicotine patch, plus some …

This study tests whether a special ketone drink can help people with alcohol use disorder drink less and feel fewer cravings. Twenty adults who drink heavily but are not seeking treatment will receive either the ketone drink or a placebo on two separate days. Researchers will use…

This study looks at whether a home-based exercise program, guided by a mobile app and activity tracker, can help people who just got a mechanical heart pump (LVAD) become more active and improve their quality of life. About 100 adults with a new HeartMate 3 LVAD will either follo…

This study is adapting a texting chatbot called Penny to help pregnant and postpartum women with opioid use disorder feel less lonely and stay engaged in their care. The chatbot, named Penny COPILOT, will send supportive messages and respond to users' texts. Researchers will test…

This study tests whether virtual face-to-face health coaching helps caregivers of hospitalized older adults improve their own self-care and reduce stress, compared to just giving them online information. About 314 caregivers who provide at least 8 hours of care per week will be r…

This small study is testing whether semaglutide, a drug used for diabetes and obesity, is safe and tolerable for people with advanced lung disease. Eight participants will take the drug for 12 weeks while researchers monitor side effects, weight, and lung function. The goal is to…

This study aims to find new biological markers (biomarkers) that can help doctors measure how active eosinophilic granulomatosis with polyangiitis (EGPA) is in a patient. EGPA is a rare immune disorder that causes asthma, high levels of certain white blood cells, and inflamed blo…

This study is building a large database of information from 250 people with Parkinson's disease and related conditions. Researchers will collect medical history, symptoms, brain images, and biological samples over time. The goal is to better understand the long-term effects of th…

This study is for adults with diabetes who need a kidney biopsy as part of their regular care. Researchers will collect and study kidney tissue, blood, urine, and genetic material from 400 participants to understand why some people's kidneys decline quickly while others do not. T…

This study is testing whether a supraglottic airway (a small mask placed over the voice box) can be used effectively to help premature babies breathe during delivery room resuscitation. The trial will include 20 infants born between 29 and 33 weeks who need breathing support at b…

This study tests a simple one-page conversation guide that doctors can use at the bedside to help patients aged 50 and older understand their anesthesia options before hip fracture surgery. The goal is to see if this tool improves shared decision-making between doctors and patien…

This study looks at how people of different ages respond to the seasonal flu vaccine. Researchers will measure antibodies and immune cells in 700 healthy adults before and after they get the shot. The goal is to understand how early-life exposure to flu viruses shapes your immune…

This study uses special brain scans (Tau PET/CT) to look at tau protein buildup in older adults with mild cognitive impairment or Alzheimer's disease. Researchers want to see how these scans relate to thinking skills and other health markers. The goal is to better understand why …

This study tests a smartphone app called Footsteps that helps aides track behaviors of children aged 4-17 with conditions like autism or ADHD. The goal is to see if the app improves data quality and leads to better mental health outcomes. Researchers will compare the app to a bas…

This study aims to learn about the experiences and outcomes of women with vasculitis who become pregnant. Researchers will use online surveys to track disease severity and pregnancy-related events in each trimester. The goal is to better understand how vasculitis affects pregnanc…