University Of Pennsylvania

This early-phase study tests a new treatment for men with advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells while resisting signals that n…

This early-phase study tests two drugs (LVGN7409 and LVGN3616 or nivolumab) given together before surgery in 27 adults with HPV-negative head and neck cancer. The goal is to see if the combination is safe and can increase immune cell activity in the tumor. Participants will have …

This study tests whether adding a drug called cevostamab after standard CAR T cell therapy can help people with relapsed or refractory multiple myeloma achieve a deeper remission. About 30 adults who have already received CAR T cells will get cevostamab infusions every 3 weeks fo…

This early-phase trial tests a new treatment called huCART19-IL18 for people with certain blood cancers (leukemia and lymphoma) that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified to better find and attack cancer cel…

This early-stage trial tests whether a brain implant that delivers small electrical pulses can safely reduce episodes of loss-of-control eating in people with severe obesity. Six adults with a BMI between 35 and 60 who have not been helped by weight-loss drugs or behavioral thera…

This study tests a new, very powerful 7 Tesla MRI scanner to see if it can take clearer pictures of the heart and help doctors better diagnose cardiomyopathy, a disease of the heart muscle. Researchers will scan 13 adults aged 20-70 to check for swelling and scarring in the heart…

This study explores whether providing medically tailored meals to heart failure patients after they leave the hospital can improve their recovery. Researchers will enroll 85 adults on Medicaid or Medicare to see if the meal delivery is practical and well-received. The goal is to …

This study compares two common acne medications—spironolactone (a hormone blocker) and doxycycline (an antibiotic)—in 350 women aged 16 to 40 with moderate to severe acne. The goal is to see which treatment reduces pimples and improves skin appearance more effectively. Participan…

This study aims to see if a personalized exercise program done 2-4 weeks before knee or hip replacement surgery can help older adults (55+) think more clearly and reduce the risk of delirium after the operation. Participants will use wearable devices and a smartphone app to track…

This study tests whether adding a doula to standard pregnancy care can improve mental health and birth outcomes for Black birthing people. 230 participants will either receive doula support (prenatal visits, labor support, and postpartum visits) or standard care. The main goal is…

This study tests whether using game-like rewards and personal coaching can help older adults (50+) become more active after leaving the hospital. Participants wear a Fitbit to track steps and are randomly assigned to a program that uses points, levels, and social support to encou…

This study tests a program of balance and strength exercises, bladder training, and home safety checks in 375 women aged 70 and older who have urinary urge incontinence. The goal is to see if this approach reduces falls and improves bladder control compared to just giving them in…

This study is testing a digital support program designed to improve the mental health and job satisfaction of doctors. It involves 293 physicians from Penn Medicine who will receive text messages, resources, and peer group support over 18 months. The goal is to see if this approa…

This study follows 300 people who had a traumatic brain injury (TBI) to better understand how epilepsy can develop years later. Researchers will check participants' recovery and watch for seizures using interviews and blood tests. The goal is to learn more about the long-term eff…

This study collects lymph fluid from the chest of 24 people (some with multiple sclerosis, some healthy) to compare immune cells. Researchers want to understand how the immune system behaves in MS and how an approved MS drug (ofatumumab) changes those cells. The goal is to learn …

This study follows 1,000 mothers and their newborns in Botswana to learn how antibiotic-resistant bacteria are passed from mother to child during pregnancy and birth. Researchers will collect samples and health information to better understand this transmission. The goal is to us…

This study uses a special imaging tracer and PET/CT scan to measure inflammation in the brain. Researchers will compare results among four groups: people with HIV, people with opioid use disorder, people with both, and healthy volunteers. The goal is to understand how these condi…

This study looks at whether a virtual program can help U.S. adults improve their physical well-being, get more involved in their communities, feel more connected to others, and reduce anxiety. About 200 adults will take part. The program involves group activities and discussions …

This study tests a program that sends text messages and educational videos to people going through fertility testing. The goal is to see if this helps them complete their tests faster. About 160 new female patients at Penn Fertility Care will take part, and half will get the prog…

This study looks at how air pollution and the body's internal clock interact to worsen asthma symptoms, especially at night. Researchers will compare 20 adults with severe asthma to healthy volunteers, measuring air pollutants and tiny molecules called microRNAs in their lungs ov…

This study looks at whether changing how people connect online can help improve attitudes toward COVID-19 vaccines and related health behaviors. About 4,500 adults in the US with internet access are taking part. Researchers are testing if reducing online segregation and increasin…

This study uses special brain scans to understand how a protein called tau relates to memory problems in older adults. Researchers will scan 150 people with normal memory and those with mild memory issues to see how tau builds up in specific brain areas over time. The goal is to …

This study looks at whether an AI tool can help doctors quickly and accurately find prostate cancer patients who qualify for a clinical trial. Researchers will compare the AI's performance to past manual methods. The goal is to make trial screening more efficient and inclusive, e…