University Of Pennsylvania

This study tests different sequences of minimally invasive dental treatments given at school to reduce tooth decay in children aged 5 to 13. The goal is to find the best personalized approach to prevent cavities and avoid over- or under-treatment. About 1,200 children from partic…

This study tests whether a new solution made from ferumoxytol nanozymes can clean root canal infections better than the standard treatment. About 72 adults needing root canals will receive either the nanozyme solution or the usual disinfectant. The goal is to see which one kills …

This study tests whether giving people leaving prison a monthly cash payment ($1,000 for the first month, then $750 for 11 months) helps them stay healthy, find stable housing, avoid going back to jail, and manage their finances. Researchers will follow 450 adults in Nebraska for…

This early-phase study tests a new approach for people with certain blood cancers (like lymphoma) that have returned or not responded to standard therapy. Participants receive their own immune cells that have been modified to attack cancer cells, along with specially edited stem …

This study looks at whether the drug sodium phenylbutyrate (NaPB) can change blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. Researchers will measure how well blood vessels work and check amino acid levels in the blood.

This study tests whether adding a second thyroid hormone (T3) to the standard T4 treatment can improve persistent symptoms like fatigue and brain fog in people with hypothyroidism. It involves 60 adults aged 18-70 who still have symptoms despite normal thyroid blood tests. Partic…

This study tests whether duloxetine, a medication that affects brain signals, can reduce disability and psychological distress in adults with inflammatory bowel disease (IBD). About 32 participants will take duloxetine for a period, and researchers will measure changes in anxiety…

This study tests a botulinum toxin called DaxibotulinumtoxinA (DAXI) for adults with blepharospasm, a condition causing uncontrollable blinking or eye muscle spasms. Twenty participants will receive up to three injection cycles over 12 months. The goal is to measure how long symp…

This study tests whether using brain images to fine-tune deep brain stimulation (DBS) settings works better than the usual method for reducing hand tremors. Twenty adults with essential tremor who already have DBS electrodes will try both approaches. The goal is to see which meth…

This early-phase study looks at whether taking aspirin at specific times of day can prevent the blood pressure increases that often happen with the pain reliever celecoxib. Researchers will monitor blood pressure in 60 healthy adults over time. The goal is to learn how timing aff…

This study tests whether digital tools like chatbots, games, and videos can increase Nigerian parents' intention to vaccinate their daughters against HPV, a virus that can cause cervical cancer. About 3,340 parents of unvaccinated girls aged 9-14 will be randomly assigned to rece…

This study uses a combination of brain stimulation (TMS) and brain scans (fMRI) to see how stimulating a specific brain area affects anxiety-related brain activity and startle responses. About 140 healthy adults will take part. The goal is to gather evidence that could lead to be…

This study follows up with people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect medical information and samples like tears, saliva, and blood from 220 adults with d…

This study tests whether giving extra cash to low-income community college students helps them finish their degree or certificate and find better jobs. About 750 students in Omaha will be randomly chosen to receive the payments or not. Researchers will track education completion,…

This study tests whether giving stroke patients and their caregivers personalized educational videos improves their understanding of stroke and reduces trips back to the hospital. About 690 participants will receive either standard education or standard education plus access to a…

This study tests whether a short 'inoculation' message can help young women in South Africa resist false claims about the new HIV prevention drug lenacapavir. About 1,500 women aged 18-29 will be randomly assigned to receive either the inoculation message or no message, then expo…

This study tests whether evolocumab, a drug that lowers 'bad' cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will receive either the drug or a placebo before surgery. Researchers will then compare the tiss…