University Of Pennsylvania

This study looks at whether a nutritional ketone supplement (Kenetik) can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a place…

This study looks at the best time to wait between taking two medicines (mifepristone and misoprostol) for treating early pregnancy loss. About 1,000 participants will choose their own time interval, and researchers will track how well the treatment works, how satisfied patients a…

This study looks at whether evolocumab, a drug that lowers bad cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will get either the drug or a placebo before surgery. Researchers will then compare the tissue …

This study looks at whether taking aspirin at specific times of day can reduce the blood pressure increases caused by the pain reliever celecoxib. Researchers will enroll 60 healthy adults and measure their blood pressure over 24 hours. The goal is to understand how timing affect…

This study aims to improve how we measure NAD+, a molecule important for energy and aging, in healthy adults. Researchers will give participants a common supplement called nicotinamide riboside and use MRI scans along with blood and urine tests to see how NAD+ levels change. The …

This study tests a new imaging drug called 64Cu-DOTA-ECL1i that may help show inflammation in the aorta, the body's main artery. Inflammation is thought to play a key role in how abdominal aortic aneurysms grow. The study will involve 30 adults with or without an aneurysm to see …

This study tests a program where nurses talk to parents of hospitalized children about safely storing firearms and offer free gun locks. The goal is to see if this conversation helps parents lock up their guns and reduces the risk of firearm injuries or suicides. About 7,200 pare…