New shot could replace opioids for knee pain in ER

NCT ID NCT07158736

Recruiting now Symptom relief Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether an ultrasound-guided nerve block can relieve knee pain better than standard painkillers like acetaminophen or opioids. About 34 adults with non-injury knee pain will be randomly assigned to get either the nerve block or usual care in the emergency department. The goal is to see if the block provides faster and longer-lasting pain relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: genicular nerve block with bupivacaine and corticosteroids
What this could lead to: If it works, this could offer a faster, more effective way to manage knee pain in the emergency room without relying on opioids.
What could go wrong: This is a small, early-phase trial with only 34 participants, so results may not apply to everyone. The nerve block carries risks like allergic reaction or temporary nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE PAIN

Contacts and locations

Locations

HUP Cedar
RECRUITING

Philadelphia, Pennsylvania, 19143, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Pennsylvania Hospital
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Pennsylvania Presbyterian Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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