Sanofi

This early-stage study tested the safety and immune response of new combination vaccines targeting multiple respiratory viruses. Healthy adults aged 18-49 received one injection of either a flu vaccine or a combined vaccine for RSV, hMPV, and parainfluenza. Researchers monitored …

This study tested whether a new yellow fever vaccine called vYF is as safe as the currently licensed vaccine, YF-VAX. Researchers enrolled 640 healthy adults aged 18-60 and gave them a single shot of either the new or existing vaccine. They then monitored participants for six mon…

This study tested a new vaccine designed to protect against four major strains of meningococcal disease (A, C, Y, W) in healthy people aged 2 to 55. Researchers compared the new shot to an already approved vaccine to see if it triggered a similar or better immune response. The ma…

This study tested a new vaccine designed to protect older adults from serious pneumococcal infections, like pneumonia. Researchers compared three versions of the new vaccine against two existing vaccines in 750 healthy adults aged 50 to 84. The main goals were to see how well the…

This large, late-stage study tested an injectable drug called amlitelimab for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that wasn't well-controlled by creams. Over 600 participants were randomly assigned to receive either the drug or a placebo in…

This study tested whether a medication called Soliqua could help people with very poorly controlled type 2 diabetes spend more time with their blood sugar in a safe, healthy range. For 16 weeks, 124 participants who were not yet on insulin wore a continuous glucose monitor to tra…

This study tested whether a multiple myeloma drug called isatuximab could be given as a simple injection under the skin instead of through an IV. Researchers compared both methods in 56 patients whose cancer had returned or stopped responding to previous treatments. The main goal…

This study aimed to see if a new, more concentrated version of insulin lispro (200 units/ml) works the same in the body as the standard version (100 units/ml). It involved 90 adults with type 1 diabetes who received a single dose of each insulin in a random order. Researchers use…

This study tested the drug dupilumab in children aged 2 to 12 with chronic spontaneous urticaria (CSU), a condition causing long-lasting, itchy hives. The goal was to see how the drug behaves in the body and check its safety in children whose hives were not controlled by standard…

This study tested an experimental drug called SAR442970 for adults with moderate-to-severe hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps and tunnels under the skin. The main goal was to see if the drug was better than a placebo (a dummy shot withou…

This early-stage study tested an experimental drug designed to calm the dangerous overactive immune response (hyperinflammation) seen in severe COVID-19. It involved 68 adults hospitalized with severe COVID-19 who were given the drug or a placebo. The main goal was to see if the …

This study tested different doses of an oral medication called SAR442168 to see how well it reduces new areas of inflammation (lesions) in the brain for people with relapsing multiple sclerosis (RMS). The 130 participants took the drug or a placebo for 16 weeks, and researchers u…

This study followed 125 people with relapsing multiple sclerosis (MS) for about five years to check the long-term safety and effectiveness of the oral drug SAR442168. The goal was to see if the drug continued to control the disease over time by reducing new brain lesions and rela…

This study tested how a new drug called itepekimab affects inflammation in the airways of people with COPD. It involved 49 current and former smokers aged 40-70 who were already on standard COPD medications. Researchers gave participants the drug for 12 weeks to see how it change…

This study tested whether an investigational drug called itepekimab could help adults with a chronic lung condition called bronchiectasis. Researchers compared two dosing schedules of the drug against a placebo in 312 participants to see if it could reduce the frequency of seriou…

This study compared the effectiveness and safety of two injectable diabetes treatments, iGlarLixi and IDegAsp, in Chinese adults. The 582 participants had type 2 diabetes that wasn't well controlled with oral medications alone. Over 24 weeks, researchers measured which treatment …

This large, completed Phase 3 trial tested whether a new injectable drug called itepekimab could help control Chronic Obstructive Pulmonary Disease (COPD) in former smokers. The study involved over 1,100 adults with moderate-to-severe COPD who had a history of frequent symptom fl…

This study tested an experimental drug called SAR441344 to see if it could safely reduce disease activity and symptoms like fatigue in adults with primary Sjögren's syndrome. For 12 weeks, 84 participants received either the drug or a placebo (inactive substance) in a double-blin…

This study tested if a new drug for moderate-to-severe eczema (amlitelimab) changes how well the body responds to common vaccines. Researchers compared vaccine antibody levels in 224 adults who received either the drug or a placebo along with tetanus and pneumonia shots. The main…

This study was the first time a new drug called SAR442085 was tested in people. It aimed to find a safe dose and see if it could help control multiple myeloma in patients whose cancer had returned or stopped responding to many standard treatments. The trial involved a small group…

This study tested whether the drug dupilumab reduces lung inflammation and mucus buildup in adults with moderate-to-severe asthma. 109 participants received either dupilumab or a placebo for 24 weeks. Researchers used detailed lung scans and breathing tests to measure changes in …

This study tested if a single pill combining two cholesterol-lowering drugs (ezetimibe and rosuvastatin) works better than rosuvastatin alone. It involved 305 Chinese adults whose high cholesterol was not well controlled despite already taking a statin. The main goal was to see i…

This study tested the highest approved dose of a replacement enzyme therapy (imiglucerase) in Chinese patients with Gaucher disease type 3, a rare genetic disorder. The goal was to see if this high dose safely improves blood cell counts, reduces enlarged organs, and improves bone…

This large, completed study tested a new injectable medication called itepekimab in people with moderate-to-severe COPD who are former smokers. The main goal was to see if the drug could reduce the yearly rate of serious symptom flare-ups (exacerbations) and improve lung function…

This study aimed to find the better dose of the drug vandetanib for people with advanced medullary thyroid cancer that was growing or causing symptoms. It involved 81 patients who were randomly assigned to receive either a 150mg or 300mg daily dose. The main goal was to compare h…

This study tested whether dupilumab, an injectable medication, could help adults with prurigo nodularis, a skin condition causing intense itch and thick bumps. The trial involved 151 people whose condition was not controlled by standard prescription creams. Participants received …

This study tested a medication called dupilumab in Japanese adults with chronic sinusitis and nasal polyps that weren't helped enough by usual treatments like steroids or surgery. Twenty-five participants received dupilumab injections for up to 52 weeks. Researchers measured whet…

This large, late-stage study tested an investigational drug called amlitelimab, given as an injection under the skin, for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema). The goal was to see if adding amlitelimab to standard topical creams could better…

This study tested whether adding a new drug called isatuximab to a standard two-drug therapy could better control multiple myeloma that had returned or stopped responding to prior treatments. It involved 302 adults whose cancer had progressed after 1 to 3 previous lines of therap…

This early-stage study tested a new inhaled gene therapy called MRT5005 in 42 adults with cystic fibrosis. The main goal was to check if the treatment was safe and tolerable when breathed in through a nebulizer. Researchers also looked for early signs that it might improve lung f…

This early-stage study tested a 4-week oral treatment called SAR441566 for people with mild to moderate psoriasis. The main goal was to check the treatment's safety and how well it was tolerated. Researchers also measured if it reduced the severity of skin lesions compared to a p…

This study tested a daily pill called eliglustat in children aged 2 to 18 with Gaucher disease, a rare genetic condition. It aimed to see if the drug was safe, how the body processed it, and if it could help control the disease by improving blood counts, organ size, and bone heal…

This study directly compared two existing biologic drugs, dupilumab and omalizumab, to see which works better for adults with severe chronic sinusitis with nasal polyps and asthma. It involved 360 participants who had not gotten enough relief from standard treatments like nasal s…

This study tested whether adding a new immunotherapy drug (SAR444245) to other standard cancer drugs could help control advanced cancers of the digestive system, including stomach, liver, and colon cancers. It involved 138 adults whose cancer had spread and was no longer respondi…

This study provided continued access to the drug sutimlimab for Japanese adults with cold agglutinin disease (CAD) who had benefited from it in previous clinical trials. The goal was to allow these patients to keep receiving the treatment until it became commercially available in…

This study tested whether dupilumab, an injectable medication, could reduce severe itch and improve skin lesions in adults with prurigo nodularis, a chronic skin condition. Participants, whose symptoms were not controlled by standard prescription creams, received either dupilumab…

This study tested whether the drug dupilumab could help control allergic fungal rhinosinusitis (AFRS), a severe sinus condition. It involved 62 adults and adolescents with confirmed AFRS who received either dupilumab or a placebo for a year. The main goal was to see if the drug c…

This study tested whether the drug sarilumab could help hospitalized adults with severe COVID-19. Sarilumab targets inflammation, which can cause serious lung problems. The trial compared the drug to a placebo in 420 patients to see if it improved recovery, reduced the need for b…

This study tested whether a combination of two medications could effectively treat a rare, serious blood disorder called immune-mediated thrombotic thrombocytopenic purpura (iTTP) without using the standard first treatment of therapeutic plasma exchange. The trial involved 51 adu…

This study tested an injectable drug called dupilumab, given with a standard steroid cream, in 62 Japanese children and teenagers (aged 6 months to 18 years) with moderate-to-severe eczema that wasn't well-controlled by their usual treatments. The main goal was to see if the drug…

This study tested whether adding a new injectable medication called amlitelimab could help adults with moderate-to-severe asthma. Researchers compared different doses of the drug against a placebo in 446 participants over about a year. The main goal was to see if the treatment co…

This large, late-stage study tested a new injectable drug called amlitelimab for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that wasn't well-controlled by creams. Nearly 600 participants were randomly assigned to receive either the drug or a place…

This study looked at whether the medication dupilumab helps repair the skin's protective barrier in people with moderate-to-severe eczema. It involved 44 Chinese patients who received dupilumab for 16 weeks. Researchers measured how well the skin held moisture before and after ge…

This study tested a new oral medication called SAR441566 to see if it could safely reduce the skin plaques and redness of moderate to severe psoriasis. Over 200 adults with the condition took different doses of the drug or a placebo pill for 12 weeks. Researchers measured how muc…

This study tested how well two drugs (plerixafor and G-CSF) work together to help the body release stem cells into the bloodstream. These stem cells are collected and later used in a transplant to rebuild the immune system after high-dose chemotherapy for multiple myeloma. The ma…

This study tested if the drug dupilumab could help people with cold urticaria, a condition where cold temperatures cause itchy hives. It involved 82 people aged 12-80 who still had symptoms even while taking standard antihistamine medications. Participants received either dupilum…

This study tested the safety and effectiveness of a long-acting insulin called Gla-300 in adults with type 2 diabetes. It involved 228 people whose blood sugar was not well controlled despite taking diabetes pills. The goal was to see if adding this once-daily insulin injection w…

This was the first study in people to test the safety of an experimental drug called SAR446959, injected directly into the knee joint. It involved 32 adults aged 45-65 with knee osteoarthritis. The main goal was to see if the injection was safe and how the body processed it, comp…

This study tested whether adding lunsekimig injections to standard asthma medications could better control moderate-to-severe asthma in adults. Researchers compared different doses against placebo injections in 685 participants worldwide to see if it reduced asthma attacks and im…

This study tested whether a drug called caplacizumab could prevent acquired thrombotic thrombocytopenic purpura (aTTP), a rare and serious blood clotting disorder, from coming back in Japanese patients. The trial involved 21 adults who were already receiving standard treatment fo…

This early-stage study tested the safety and how the body processes a new asthma medication called SAR443765. The trial involved 36 participants, including healthy adults and people with mild-to-moderate asthma, who received either the drug or a placebo. Researchers monitored sid…

This study tested whether adding dupilumab injections to standard nasal spray therapy could better control chronic sinusitis with nasal polyps in Chinese adults. Over 24 weeks, researchers compared the drug to a placebo in 63 participants to see if it reduced polyp size and sympt…

This small, early study aimed to measure how long a new experimental drug (BIVV001) stays active in the body compared to two standard treatments for severe hemophilia A. It involved 13 adult men who had previously been treated for their condition. Researchers gave each participan…

This study aimed to see if the approved drug Fabrazyme, used to manage Fabry disease, could be safely infused at a faster rate. It involved 8 participants already stable on the treatment to test if shortening infusion times was tolerable. The goal was to reduce the treatment time…

This Phase 3 trial tested whether the drug SAR442168 could slow disability progression in people with primary progressive multiple sclerosis (PPMS). 767 participants were randomly assigned to receive either the drug or a placebo for 12 to 60 months. Researchers measured changes i…

This study tested how well and safely a long-acting insulin called glargine U300 worked for Chinese adults whose type 2 diabetes was not well controlled. It involved 570 participants who either started this insulin for the first time or switched to it from another insulin. Resear…

This large, completed study tested whether adding the drug aflibercept to standard chemotherapy (docetaxel) helped people with advanced non-small cell lung cancer live longer. It involved over 900 participants whose cancer had worsened after one prior platinum-based treatment. Th…

This study tested whether a special infrared therapy patch could safely reduce pain and improve movement for people with recent, mild-to-moderate low back pain. Over 200 participants were randomly assigned to use the patch or receive no patch treatment over 5 days. The main goal …

This study checked the safety and effectiveness of a common allergy medication, Allegra D, in people with allergic rhinitis (hay fever). Over 200 participants aged 12 and up took the medication for up to 13 days and were monitored for side effects. Researchers measured how well i…

This study followed 112 adults with severe, hard-to-control asthma who were starting treatment with the drug dupilumab (brand name Dupixent®). The main goal was to see if their quality of life improved over one year of treatment in a real-world setting, outside of a tightly contr…

This study tested whether an existing eczema medication, dupilumab, could improve sleep quality for adults with moderate-to-severe atopic dermatitis. It involved 188 participants who received either the drug or a placebo for 12 weeks, with researchers tracking sleep quality, itch…

This study aims to understand how often adults with chronic immune thrombocytopenia (ITP) experience problems with thinking, memory, and fatigue. Researchers will collect information from medical records and blood tests from about 100 participants to look for links between these …

This early-stage study tested how the body absorbs two different pill versions of an experimental drug called rilzabrutinib, which is being developed for autoimmune disorders. The study involved 28 healthy volunteers who took single doses of the pills, sometimes with food and som…

This was a very early, small study to see how the body processes a new oral drug (SAR441566) being developed for rheumatoid arthritis. It tested single, increasing doses in 10 healthy Japanese male volunteers to check for safety and measure drug levels in the blood. The goal was …

This early-stage study checked how two common medications (gemfibrozil and rifampicin) affect the way the body processes an experimental drug for multiple sclerosis (SAR442168). It involved 30 healthy male volunteers to measure drug levels and safety. The goal was to understand p…

This early-stage study aimed to understand how liver problems affect how the body processes a single dose of an experimental drug called venglustat. It involved 26 adults, some with varying levels of liver impairment and others with normal liver function. The main goal was to mea…

This early-stage study aimed to understand how two slightly different versions of the experimental drug amlitelimab are processed by the body and to check for side effects. It involved 32 healthy adult volunteers who received a single injection. The main goal was to compare how t…

This early study aimed to understand how the body processes an experimental drug for multiple sclerosis (SAR442168). Six healthy male volunteers took a single, traceable dose so researchers could measure how much drug was absorbed, how it was broken down, and how it left the body…

This study aimed to understand if a specific gene mutation (ABCG2) affects how much of the multiple sclerosis drug teriflunomide stays in a patient's body and its safety. It involved 82 Chinese patients with relapsing multiple sclerosis who took the standard 14 mg dose daily for …

This study aimed to understand how the approved eczema medication dupilumab affects the skin's barrier function. It involved 52 patients with moderate to severe atopic dermatitis who received dupilumab, plus some healthy volunteers for comparison. Researchers used a special tape-…

This was the first study in humans to test the safety and body's response to a new drug called SAR441255. It involved 48 healthy to slightly overweight adults who received a single injection. The main goal was to see if it was safe and to measure how it affected blood sugar and i…

This early-stage study tested whether an experimental oral drug for rheumatoid arthritis makes skin more sensitive to sunlight. Researchers gave the drug to healthy adults and measured their skin's reaction to ultraviolet light compared to people taking a placebo or a known sun-s…

This early-stage study aimed to understand how the body absorbs, breaks down, and eliminates an experimental oral drug called SAR439859, which is being developed for breast cancer. Six healthy post-menopausal women received a single, very small dose containing a safe radioactive …

This study aimed to compare how the body processes a new version of the drug dupilumab versus the currently available version. The trial involved 182 healthy adults who received a single injection of either the new or current drug. Researchers measured drug levels in the blood ov…

This study aimed to understand how liver problems affect the way the body processes the drug fexinidazole. It involved 21 adults, some with mild or moderate liver impairment and others with normal liver function, who each took a single dose. Researchers measured the drug levels i…

This study aimed to understand how the medication dupilumab affects the skin's protective barrier in children with moderate to severe eczema (atopic dermatitis). It involved 41 children who received the drug, and researchers used a special tape-stripping method to measure how wel…

This early-stage study tested the safety of a new drug called SAR441344 in 56 healthy volunteers. Researchers gave participants single and repeated doses, either through an IV or injection under the skin, to see how their bodies reacted. The main goal was to check for side effect…

This was an early-stage study to check the safety and see how the body processes a new drug called SAR444336. It involved 76 healthy adult volunteers who received either the drug or a placebo. The main goal was to gather basic safety information and understand how the drug moves …

This study aimed to understand how the approved eczema medication dupilumab works to reduce chronic itching. Researchers took small skin samples from 54 adults with moderate-to-severe eczema before and after treatment to see if the drug changed nerve fibers in the skin. The goal …

This study aimed to find out how often children with an enlarged spleen of unknown cause might have rare diseases like Gaucher disease. Researchers observed 60 children under 18 who had an enlarged spleen that couldn't be explained by common conditions. The goal was to gather inf…

This study followed 378 children with asthma for about a year to check the long-term safety and side effects of a medication called dupilumab. The children had all taken this medication in a previous study. Researchers also measured how well the drug continued to control asthma s…