Sanofi

This study tested a single combination shot that aims to protect against both COVID-19 and influenza at the same time. About 980 adults aged 50 and older received either the combo vaccine, a flu shot alone, a COVID-19 shot alone, or both shots separately. Researchers monitored sa…

This study tested a new yellow fever vaccine (vYF) to see if it is as safe as the current licensed vaccine (YF-VAX). A total of 640 healthy adults aged 18 to 60 received a single shot of either the new or the existing vaccine. Researchers monitored side effects like pain, fever, …

This study tested different versions of an mRNA vaccine designed to protect against RSV, a common respiratory virus. It involved 240 healthy adults aged 18 to 49 who received a single shot. The main goals were to check the vaccine's safety and how well it triggers an immune respo…

This study tested a single dose of a new meningococcal conjugate vaccine in 360 healthy people aged 2 to 55. The goal was to see if the new vaccine works as well as an existing vaccine at protecting against four types of meningococcal bacteria. Researchers measured immune respons…

This study tested a new pneumococcal vaccine (SP0202) in 750 healthy adults aged 50 to 84. The goal was to see how well it triggered an immune response and how safe it was compared to two existing vaccines (Prevnar 13 and Pneumovax 23). Participants received a single shot and wer…

This study tested a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 980 adults aged 50 and older took part. Researchers checked how safe the vaccine was and how well it boosted the immune system compared to getting separate…

This early-stage study tested the safety and immune response of new vaccines that combine protection against influenza, RSV, hMPV, and parainfluenza virus type 3. A total of 270 healthy adults aged 18 to 49 received a single shot of one of the vaccine formulations. Researchers mo…

This study tested a new medicine called SAR441344 in 84 adults with primary Sjögren's syndrome, an autoimmune disease causing dry eyes, dry mouth, and fatigue. Participants received either the drug or a placebo for 12 weeks. The goal was to see if the drug reduces disease activit…

This study tested a cancer drug called isatuximab given either as a shot under the skin or through an IV, along with two other medicines (pomalidomide and dexamethasone), in 56 adults with multiple myeloma that had returned or stopped responding to prior treatments. The main goal…

This study tested the drug eliglustat in 57 children aged 2 to 18 with Gaucher disease types 1 and 3. The goal was to see how safe the drug is, how the body processes it, and whether it helps control the disease. Some children also took another drug called imiglucerase. The study…

This study tested whether adding dupilumab (an injectable drug) to standard steroid creams can better control eczema in Japanese children aged 6 months to 18 years whose eczema was not helped by existing treatments. The trial involved 62 participants and lasted 16 weeks. The main…

This study tested a drug called sarilumab in 420 adults hospitalized with severe or critical COVID-19. The goal was to see if it could help patients recover faster and improve survival. Sarilumab works by calming an overactive immune response, but it is not a cure and patients ma…

This study tested a new drug, SAR442970, in 86 adults with moderate to severe hidradenitis suppurativa (HS), a chronic skin condition causing painful lumps. The goal was to see if the drug reduces skin inflammation better than a placebo. Participants received either the drug or a…

This study tested the drug dupilumab in 63 Chinese adults with chronic sinusitis and nasal polyps (growths in the nose). Participants received either dupilumab injections or a placebo, along with a standard nasal steroid spray, for 24 weeks. The goal was to see if dupilumab could…

This study tested a single pill that combines two cholesterol-lowering medicines (ezetimibe and rosuvastatin) in 305 Chinese adults whose high cholesterol was not well controlled with a statin alone. After 8 weeks, the combo pill lowered LDL (bad) cholesterol more than the statin…

This study looked at the long-term safety and effectiveness of the drug SAR442168 in 125 people with relapsing multiple sclerosis who had already completed a previous study. Participants continued taking the drug for up to 240 weeks. The main goal was to track side effects, and t…

This study tested a drug called itepekimab in 312 adults with non-cystic fibrosis bronchiectasis, a lung condition that causes chronic cough and infections. The goal was to see if it could reduce the number of moderate or severe lung flare-ups compared to a placebo. Participants …

This study tested a long-acting insulin called Gla-300 in 228 adults with type 2 diabetes whose blood sugar was not well controlled with oral medications. Participants had never used insulin before. The main goal was to check safety, including side effects and low blood sugar eve…

This study gave sutimlimab to 7 adults with cold agglutinin disease (CAD) who had already completed earlier studies and still needed treatment. The goal was to keep providing the drug until it became commercially available in Japan. Researchers tracked side effects and serious si…

This study compared two medications, dupilumab and omalizumab, in 360 adults with severe nasal polyps and asthma. The goal was to see which drug better shrinks polyps and improves sense of smell after 24 weeks. Participants received either drug and were monitored for symptom chan…

This study tested whether adding the drug isatuximab to a standard two-drug regimen (carfilzomib and dexamethasone) helps people with multiple myeloma that has come back or stopped responding to prior treatments. 302 adults who had already received 1 to 3 prior therapies took par…

This early-stage study tested a new oral drug, SAR441566, in 10 healthy Japanese men to see how the body processes it and if it is safe. The drug is being developed to help control rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Since this is a ph…

This study tested a new oral drug, SAR441566, in 221 adults with moderate to severe plaque psoriasis. Participants received either the drug or a placebo for 12 weeks. The main goal was to see if the drug could reduce psoriasis severity by at least 75% compared to starting point.

This study tested an experimental drug called SAR442168 against a placebo in 767 adults with primary progressive multiple sclerosis (PPMS). The goal was to see if the drug could delay worsening disability. Participants took the drug or placebo and were monitored for changes in mo…

This study tested whether adding plerixafor to the standard drug G-CSF helps collect enough stem cells for a transplant in people with multiple myeloma. Fifty-three adults in remission joined the study. The goal was to see if this combination could collect the needed cells in few…

This study tested a new drug called SAR444245 (THOR-707) combined with other cancer treatments in 138 adults with advanced or metastatic gastrointestinal cancers, including esophageal, stomach, liver, and colorectal cancers. The goal was to see if the combination could shrink tum…

This study looked at how dupilumab, a medication for moderate to severe eczema (atopic dermatitis), improves the skin's barrier function in Chinese patients. 44 participants received the drug for 16 weeks, and researchers measured water loss from the skin to see how well the barr…

This study tested two injectable diabetes drugs, iGlarLixi and IDegAsp, in 582 Chinese adults with type 2 diabetes whose blood sugar was not well controlled by oral medications. The goal was to see which drug worked better at lowering blood sugar over 24 weeks. Both drugs are use…

This early-stage study tested a new drug called SAR442085 in 37 adults with multiple myeloma that had returned or stopped responding to prior treatments. The main goals were to find a safe dose and check for early signs that the drug can shrink or control the cancer. The study is…

This study tested a long-acting insulin called insulin glargine U300 in 570 Chinese adults with type 2 diabetes whose blood sugar was not well controlled. Some participants had never used insulin before, while others switched from another basal insulin. The main goal was to see h…

This study tested a drug called dupilumab in 62 people with allergic fungal rhinosinusitis, a condition where fungus causes severe sinus inflammation. The goal was to see if the drug could reduce sinus blockage seen on CT scans and improve symptoms like congestion and sense of sm…

This study tested a drug called itepekimab in over 1,100 former smokers with moderate-to-severe COPD. The goal was to see if it could reduce the number of sudden breathing attacks (exacerbations) compared to a placebo. Participants received injections of the drug or a dummy shot …

This study tested a new drug called amlitelimab in 437 adults with moderate-to-severe asthma. Participants received either the drug or a placebo as an add-on to their usual asthma medications. The main goal was to see if amlitelimab could reduce the number of severe asthma attack…

This early-stage study tested an experimental drug called SAR443122 in 68 hospitalized adults with severe COVID-19. The goal was to see if the drug could safely reduce dangerous inflammation, measured by a blood marker called CRP. Participants received either the drug or a placeb…

This study tested a new drug, lunsekimig, in 685 adults aged 18-80 with moderate-to-severe asthma. Participants received either the drug or a placebo as an add-on to their usual treatment. The main goal was to see if lunsekimig could reduce the number of asthma attacks and improv…

This study tested a new medication called SAR442168 in 130 adults with relapsing multiple sclerosis. The goal was to find the best dose to reduce new active brain lesions seen on MRI scans. Participants received the drug or a placebo for 12 to 16 weeks, and researchers measured c…

This study tested a drug called itepekimab in over 1,200 people with moderate-to-severe COPD, a serious lung disease often caused by smoking. The goal was to see if it could reduce the number of sudden worsening episodes (exacerbations) and improve breathing. Participants receive…

This study looked at whether Soliqua 100/33, a combination insulin and GLP-1 drug, can help people with very uncontrolled type 2 diabetes (HbA1c ≥9%) spend more time in a healthy blood sugar range. About 124 participants who were already on at least two diabetes pills wore a cont…

This study tested a drug called caplacizumab in 21 Japanese adults with acquired thrombotic thrombocytopenic purpura (aTTP), a rare condition causing dangerous blood clots. The goal was to see if the drug could prevent the disease from coming back. Participants received the drug …

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that wasn't helped enough by creams or other treatments. About 589 participants received either the study drug or a…

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe eczema that didn't get better with creams or other treatments. The goal was to see if it could clear or nearly clear the skin and reduce eczem…

This study looked at whether a higher dose of the drug imiglucerase can safely improve blood counts, reduce organ swelling, and ease bone pain in Chinese patients with Gaucher disease type III. Twelve patients over age 2 received the maximum approved dose for one year. The goal w…

This study tested a new inhaled medicine called MRT5005 in 42 adults with cystic fibrosis. The goal was to see if it is safe and to measure how it affects lung function. The medicine was given as a mist through a nebulizer, and participants were monitored for side effects and cha…

This study followed 3 people with acid sphingomyelinase deficiency (ASMD) who had already completed earlier studies. They received enzyme replacement therapy with olipudase alfa every 2 weeks to check for side effects and safety. The study lasted until the drug was approved for u…

This study tested the drug dupilumab in 25 adults with chronic sinusitis and nasal polyps that were not well controlled by other treatments. Participants received injections of dupilumab for up to 52 weeks. The main goal was to see if the drug could shrink nasal polyps and improv…

This study tested the drug dupilumab in 82 people aged 12 to 80 with cold urticaria (hives triggered by cold) that antihistamines couldn't fully control. The main goal was to see if dupilumab could prevent hives after an ice cube test at 24 weeks. The trial was completed and comp…

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe eczema that didn't get better with creams. Participants also used standard steroid creams during the study. The goal was to see if the shot co…

This study looked at the long-term safety of dupilumab in 378 children with asthma who had already taken the drug in a previous study. The main goal was to track side effects over one year. A smaller part of the study in Japan also checked how well the drug worked in kids aged 6 …

This study tested two daily doses (150 mg vs 300 mg) of the drug vandetanib in 81 adults with advanced medullary thyroid cancer that had spread or caused symptoms. The goal was to see which dose better shrinks tumors and to compare side effects. Participants took the drug by mout…

This study tested whether a combination of caplacizumab and immunosuppressive drugs can treat immune-mediated thrombotic thrombocytopenic purpura (iTTP) without the usual first-line plasma exchange. Fifty-one adults with iTTP received the drug combo for up to 12 weeks, followed b…

This study looked at how dupilumab, a medication for moderate to severe eczema, improves the skin's barrier function. Researchers measured water loss through the skin before and after treatment in 52 patients. The goal was to see if the drug helps restore the skin's natural prote…

This study tested whether adding a drug called aflibercept to standard chemotherapy (docetaxel) helps people with advanced non-small cell lung cancer live longer when their first treatment stops working. Over 900 participants received either the new combination or chemotherapy pl…

This study tested whether the drug dupilumab could reduce lung inflammation and mucus buildup in adults with moderate-to-severe asthma. Over 24 weeks, researchers compared dupilumab against a placebo in 109 participants, using special lung scans and breathing tests to measure cha…

This study tested a drug called dupilumab in 151 adults with prurigo nodularis, a skin condition causing intense itching and bumps. Participants had severe itch not controlled by prescription creams. The goal was to see if dupilumab could reduce itch and clear skin lesions. Resul…

This study tested a fixed-dose combination of fexofenadine and pseudoephedrine (Allegra D) in 203 people aged 12 and older with allergic rhinitis. Participants took the drug for up to 13 days, and researchers tracked side effects and symptom improvement using nasal and total symp…

This study tested a new drug called lunsekimig in 79 adults with chronic sinusitis and nasal polyps that didn't get better with standard steroid sprays. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goal was to see if the drug …

This study tested whether people with Fabry disease can safely receive their Fabrazyme infusions faster and with less fluid. Eight participants who had been on Fabrazyme for at least 3 months without reactions took part. The goal was to reduce infusion time while keeping the trea…

This study looked at whether a patient outreach program could help people with advanced medullary thyroid cancer spend less time dealing with moderate-to-severe side effects from the drug vandetanib. About 205 adults took part. The goal was to see if extra support and monitoring …

This study tested whether dupilumab, an injectable drug, improves sleep in 188 adults with moderate to severe eczema who also had trouble sleeping. Participants received either dupilumab or a placebo for 12 weeks. The main goal was to measure changes in sleep quality and itch sev…

This study tested the safety and drug levels of dupilumab in 15 children aged 2 to 12 with chronic spontaneous urticaria (CSU), also known as long-lasting hives, that did not get better with standard antihistamines. The children received dupilumab for 24 weeks and were monitored …

This study tested a medicine called dupilumab in 160 adults with prurigo nodularis, a skin condition that causes intense itching and hard bumps. Participants had severe itch that wasn't helped by prescription creams. The goal was to see if dupilumab could reduce itching and clear…

This study tested a new drug called lunsekimig in 150 adults with moderate-to-severe eczema who did not get enough relief from topical treatments. Participants received one of three doses of the drug or a placebo as a shot under the skin for 24 weeks. The main goal was to see how…

This study tested a single injection of a new drug (SAR446959) in the knees of 32 adults aged 45-65 with osteoarthritis. The main goal was to check safety and side effects, not to prove it works. Participants were followed for about 28 weeks to monitor any reactions and how the d…

This study followed 112 adults with severe asthma who started taking dupilumab (Dupixent). Researchers measured changes in quality of life using a standard questionnaire at 12, 24, and 52 weeks. The goal was to see how the drug helps people breathe easier and feel better in every…

This study looked at how dupilumab, a treatment for moderate-to-severe eczema, changes nerve fibers in the skin and reduces itching. 54 adults with chronic itch took part. Researchers took skin samples to measure nerve density and branching before and after treatment. The goal wa…

This early-stage study tested an experimental oral drug, SAR441566, in 38 adults with mild to moderate psoriasis. The main goal was to check safety and tolerability over 4 weeks, while also measuring how well it reduced skin symptoms like scaling and redness. Participants were ra…

This study tested a special infrared patch (FIRTECH) to see if it helps people with mild to moderate short-term low back pain. 221 adults with pain lasting less than a month took part. The main goal was to measure pain reduction after 5 days of using the patch, while also checkin…

This early-stage study tested a new drug called SAR443765 in 36 people to see if it is safe and how the body processes it. Healthy volunteers received single or multiple doses, while people with mild-to-moderate asthma got a single dose. The main goal was to check for side effect…

This study looked at how two common drugs, gemfibrozil and rifampicin, change the way the body processes a multiple sclerosis medicine called SAR442168. Thirty healthy men aged 18 to 45 took part. The goal was to gather information, not to treat any disease.

This study tested how well two different tablet forms of the drug rilzabrutinib are absorbed by the body, and whether food changes that absorption. 28 healthy adults aged 18-55 took single doses of each tablet form in random order. The goal was to gather information, not to treat…

This study tested a new drug called efanesoctocog alfa in 13 adults with severe hemophilia A. The goal was to see how long it stays active in the body compared to standard clotting factor treatments. Participants received single injections of each drug in a fixed order, and resea…

This study looked at how chronic immune thrombocytopenia (ITP) affects thinking skills and fatigue in adults. Researchers measured cognitive function and inflammation markers in 97 patients using blood tests and computer-based assessments. The goal was to better understand the li…

This study looked at how healthy men absorb, process, and eliminate a new multiple sclerosis drug called SAR442168. Six men took a single dose, and researchers measured how much of the drug left their body in urine and stool. The goal was to understand the drug's metabolism and s…

This study looked at whether safety information about the epilepsy drug Depakine (sodium valproate) is reaching doctors and pharmacists in Saudi Arabia. Researchers surveyed 455 healthcare professionals to see if they read and understood the safety materials. No treatment was giv…

This study tested whether a higher-strength insulin lispro (200 U/mL) works the same as the standard strength (100 U/mL) in people with type 1 diabetes. 90 adults received a single dose of each insulin in random order, and researchers measured how the body absorbed and responded …

This early-stage study tested two different versions of an experimental drug called amlitelimab in 32 healthy adults. The goal was to see how the body absorbs and processes each version and to check for any side effects. Participants received a single injection and were monitored…

This study tested the drug dupilumab in 41 children aged 6 to 12 with moderate to severe eczema (atopic dermatitis). The goal was to see if the drug improves the skin's barrier function by measuring how much water escapes through the skin. Researchers compared the children's skin…

This study looked at whether the eczema drug amlitelimab changes how well vaccines work in adults with moderate-to-severe atopic dermatitis. About 224 participants received either amlitelimab or a placebo along with two standard vaccines (tetanus/diphtheria/pertussis and pneumoni…

This study checks whether a new medicine for rheumatoid arthritis (SAR441566) makes skin more sensitive to sunlight or UV light. Healthy adults aged 18 to 55 will take the drug or a placebo, and some will take a known light-sensitive drug for comparison. Researchers measure skin …

This study looked at how a new medicine called amlitelimab affects the way the body processes other drugs in adults with moderate-to-severe atopic dermatitis (eczema). 23 participants took part. The goal was to understand potential drug interactions to ensure safe use with other …

This study tested how a single 1200 mg dose of fexinidazole is handled by the body in people with mild or moderate liver impairment compared to those with normal liver function. 21 adults took part to measure drug levels and safety. The goal was to understand if liver problems ch…

This study tested whether a new version of the drug dupilumab works the same in the body as the current version. It involved 182 healthy adults aged 18 to 65 who received a single injection of either the new or current drug. The goal was to compare drug levels and safety, not to …

This study looked at how a specific gene change (ABCG2 mutation) affects the amount of the MS drug teriflunomide in the body and its safety. 82 Chinese adults with relapsing multiple sclerosis took the drug once daily for 24 weeks. Researchers measured drug levels and tracked sid…

This early-stage study tested the safety and tolerability of a new drug, SAR441344, in 56 healthy adults. Participants received either the drug or a placebo through an IV or injection. The main goal was to see if the drug caused any side effects, not to treat any disease.

This study asked over 1,000 adults in the U.S. about their experiences after receiving a trivalent recombinant influenza vaccine. Participants completed a 30-minute online survey about pain, anxiety, and any reactions they had. The goal was to understand how well the vaccine is t…

This study analyzed health insurance records of over 81,000 people aged 14 to 44 in Germany to understand how common chlamydia infections are and what complications they can cause. Researchers looked at short-term problems, long-term health issues, and how much these infections c…

This study checked 60 children under 18 with an enlarged spleen that had no clear cause. Doctors looked for Gaucher disease and other rare conditions using blood tests and genetics. The goal was to find how common these diseases are in such cases.

This early-stage study tested a single dose of an experimental drug called SAR441255 in 48 healthy adults who were lean to overweight. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked at its effects on blood sugar and insulin lev…

This study looked at how the drug itepekimab affects airway inflammation in people with COPD who are current or former smokers. 49 adults aged 40-70 took part, and the goal was to understand the drug's mechanism of action, not to test a cure. Participants stayed on their usual CO…

This study tested whether two different injection devices deliver the same amount of amlitelimab into the body. 212 healthy adults received a single dose of the drug through one of the devices. Researchers measured drug levels in the blood and checked for side effects to see if t…

This study looked at how different levels of liver impairment affect the way the body handles a single dose of the drug venglustat. Researchers compared adults with mild, moderate, or severe liver problems to those with healthy livers. The goal was to understand safety and how th…

This study looked at how a breast cancer drug called SAR439859 is absorbed, broken down, and removed from the body. Six healthy postmenopausal women took a single dose of the drug with a tiny radioactive marker. Researchers measured the drug in blood, urine, and stool to understa…

This study tested a new investigational drug, SAR444336, in 76 healthy adults to see if it is safe and how the body handles it. Participants received either the drug or a placebo as single or repeated injections. The goal was to gather initial safety data before testing the drug …