New shot could tame uncontrollable itch of prurigo nodularis

NCT ID NCT04183335

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested the drug dupilumab in 151 adults with prurigo nodularis, a condition causing intense itching and raised skin bumps. Participants had severe itch that creams could not control. They received either dupilumab injections or a placebo for 24 weeks. The main goal was to see if dupilumab could reduce itch by at least 4 points on a 0-10 scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dupilumab (injection)
What this could lead to: If it works, this could provide a new treatment option for people with prurigo nodularis whose severe itch and skin bumps are not controlled by creams.
What could go wrong: This is a single Phase 3 trial with 151 participants. Results may not apply to everyone, and side effects like injection reactions or infections are possible.

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Conditions

The condition(s) this trial relates to.

neurodermatitis prurigo nodularis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEURODERMATITIS

Contacts and locations

Locations

Investigational Site Number :0320001

Buenos Aires, C1121ABE, Argentina
Investigational Site Number :0320002

CABA, Buenos Aires, C1425BEN, Argentina
Investigational Site Number :0320003

San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina
Investigational Site Number :0320004

CABA, Buenos Aires F.D., C1425BEA, Argentina
Investigational Site Number :0320005

CABA, Buenos Aires, C1055AAO, Argentina
Investigational Site Number :0320006

Caba, 1425DES, Argentina
Investigational Site Number :0320007

CABA, Buenos Aires F.D., C1431EKK, Argentina
Investigational Site Number :0320008

CABA, Buenos Aires, C1023AAB, Argentina
Investigational Site Number :0320009

Mendoza, M5500, Argentina
Investigational Site Number :1560001

Chengdu, 610041, China
Investigational Site Number :1560002

Hangzhou, 310006, China
Investigational Site Number :1560003

Wuxi, 214002, China
Investigational Site Number :1560004

Beijing, 100050, China
Investigational Site Number :2500005

Reims, 51100, France
Investigational Site Number :3920001

Shinagawa-Ku, Tokyo, 141-8625, Japan
Investigational Site Number :3920002

Nagoya, 454-8509, Japan
Investigational Site Number :3920003

Tokorozawa-shi, Saitama, 359-8513, Japan
Investigational Site Number :3920004

Bunkyo-ku, Tokyo, 113-8519, Japan
Investigational Site Number :3920005

Kyoto, Kyoto, 606-8507, Japan
Investigational Site Number :3920006

Itabashi-ku, Tokyo, 173-8610, Japan
Investigational Site Number :3920007

Nagasaki, Nagasaki, 852-8501, Japan
Investigational Site Number :3920009

Yokohama, Kanagawa, 236-0004, Japan
Investigational Site Number :3920010

Izumo-shi, Shimane, 693-8501, Japan
Investigational Site Number :4100001

Incheon, 21565, South Korea
Investigational Site Number :4100002

Seoul, Seoul-teukbyeolsi, 03080, South Korea
Investigational Site Number :4100003

Seoul, Seoul-teukbyeolsi, 03722, South Korea
Investigational Site Number :4100004

Seoul, Seoul-teukbyeolsi, 07441, South Korea
Investigational Site Number :4100005

Incheon, Incheon-gwangyeoksi, 21431, South Korea
Investigational Site Number :4100007

Seongnam-si, Gyeonggi-do, 13620, South Korea
Investigational Site Number :4840001

Monterrey, Nuevo León, 64460, Mexico
Investigational Site Number :4840002

Guadalajara, Jalisco, 44100, Mexico
Investigational Site Number :4840003

Veracruz, 91910, Mexico
Investigational Site Number :4840005

Monterrey, Nuevo León, 64718, Mexico
Investigational Site Number :4840006

Guadalajara, 44210, Mexico
Investigational Site Number :6430001

Stavropol, 355030, Russia
Investigational Site Number :6430002

Saint Petersburg, 197022, Russia
Investigational Site Number :6430005

Moscow, 107076, Russia
Investigational Site Number :6430006

Moscow, 125993, Russia
Investigational Site Number :6430007

Krasnodar, 350020, Russia
Investigational Site Number :6430008

Chelyabinsk, 454048, Russia
Investigational Site Number :6430009

Saratov, 410026, Russia
Investigational Site Number :6430010

Moscow, 115522, Russia
Investigational Site Number :8400001

Dublin, Ohio, 43016, United States
Investigational Site Number :8400002

Pflugerville, Texas, 78660, United States
Investigational Site Number :8400003

Newnan, Georgia, 30263, United States
Investigational Site Number :8400004

Columbus, Georgia, 31904, United States
Investigational Site Number :8400005

Norfolk, Virginia, 23502, United States
Investigational Site Number :8400006

Bellaire, Texas, 77401, United States
Investigational Site Number :8400007

Tulsa, Oklahoma, 74136, United States
Investigational Site Number :8400009

Athens, Ohio, 45701, United States
Investigational Site Number :8400010

Philadelphia, Pennsylvania, 19104, United States
Investigational Site Number :8400011

Gilbert, Arizona, 85234, United States
Investigational Site Number :8400013

St Louis, Missouri, 63110, United States
Investigational Site Number :8400014

Miami, Florida, 33136, United States
Investigational Site Number :8400015

Charleston, South Carolina, 29414, United States
Investigational Site Number :8400016

Indianapolis, Indiana, 46250, United States
Investigational Site Number :8400017

Sandy Springs, Georgia, 30328, United States
Investigational Site Number :8400018

Clarkston, Michigan, 48346, United States
Investigational Site Number :8400019

San Antonio, Texas, 78249, United States
Investigational Site Number :8400022

Fort Smith, Arkansas, 72916, United States
Investigational Site Number :8400024

East Windsor, New Jersey, 08520, United States
Investigational Site Number :8400025

Houston, Texas, 77058, United States
Investigational Site Number :8400026

Sacramento, California, 95816, United States

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