Sanofi

This study aimed to compare the effectiveness and safety of two long-acting insulin products (Gla-300 and IDeg-100) in adults with type 2 diabetes and reduced kidney function who had never used insulin before. Participants were randomly assigned to receive one of the two insulins…

This study tested an experimental drug called SAR444245, both alone and combined with other cancer treatments, for people with advanced B-cell lymphoma that had returned or stopped responding to previous therapies. It involved 14 participants aged 12 and older who had already tri…

This early-stage study tested a new drug called SAR443216 in people with advanced solid tumors that have a protein called HER2 and have stopped responding to other treatments. The main goals were to find a safe dose and see how the body processes the drug. Researchers also looked…

This study tested an experimental drug called SAR444656 for adults with moderate to severe atopic dermatitis (eczema) that wasn't well-controlled with creams. Participants were randomly assigned to receive one of three doses of the drug or a placebo (inactive substance) for 16 we…

This study aimed to see if a new drug combination (amcenestrant plus palbociclib) could better control advanced breast cancer compared to the standard treatment (letrozole plus palbociclib). It involved over 1,000 adults with a specific type of breast cancer (ER+/HER2-) that had …

This study tested a new oral drug called amcenestrant for postmenopausal women with advanced, estrogen receptor-positive breast cancer. The main goals were to find safe doses and see if the drug, given alone or with other cancer therapies, could help control the disease. The tria…

This study tested if a new drug called amcenestrant was better than the standard drug letrozole at slowing the growth of breast cancer cells before surgery. It involved 105 postmenopausal women with early-stage, hormone-sensitive breast cancer. Participants took one of the drugs …

This study tested whether adding an experimental drug called SAR444245 to other cancer treatments could help control advanced lung cancer or mesothelioma. It involved 106 adults whose cancer had progressed despite prior treatments. The trial was terminated early, and its main goa…

This early-stage study aimed to check the safety and side effects of an oral drug called DNL747 in people with ALS (Lou Gehrig's disease). It involved 15 participants who took the drug or a placebo in a crossover design. The main goal was to see how the body processes the drug an…

This study tested an oral drug called SAR443820 to see if it could reduce nerve damage in people with multiple sclerosis (MS). About 174 adults with different types of MS took either the drug or a placebo for nearly a year. The trial was stopped early because the drug did not mee…

This study aimed to test whether an oral drug called tolebrutinib could help control symptoms and improve daily life for adults with moderate-to-severe generalized myasthenia gravis (gMG), a chronic autoimmune disease that causes muscle weakness. It was a large Phase 3 trial desi…

This study tested whether adding a new targeted drug called tusamitamab ravtansine to standard immunotherapy and chemotherapy could better control advanced lung cancer. It involved 57 adults with a specific type of non-small cell lung cancer that had spread and tested positive fo…

This was an early, small study to check the safety of a single dose of an experimental drug called SAR439459 in adults with osteogenesis imperfecta (brittle bone disease). The main goal was to see if the drug was safe and how the body processed it, while also looking for early si…

This study tested whether adding an experimental drug called SAR444245 to standard cancer treatments could help people with advanced head and neck cancer. It involved 59 adults whose cancer had returned or spread. The goal was to see if the combination led to more tumor shrinkage…

This early-stage study aimed to see if the drug hydroxychloroquine could reduce the amount of COVID-19 virus and ease symptoms in adults with mild illness. It involved only 8 participants who took the drug or a placebo for 10 days. The trial was terminated early and did not proce…

This study aimed to see how well and how safely the antibiotic teicoplanin worked for adults hospitalized with diarrhea and colon inflammation caused by a C. difficile infection. About 50 participants were to take the drug orally for 7 to 14 days. The main goals were to see if it…

This study tested an investigational drug called SAR444656 for adults with moderate to severe hidradenitis suppurativa (HS), a painful, chronic skin condition. It aimed to see if the drug could reduce the number of painful skin lumps and improve symptoms compared to a placebo. Th…

This early-stage study tested a new treatment called SAR445419, which uses 'off-the-shelf' natural killer (NK) cells—a type of immune cell made in a lab. It was given to a small group of adults whose acute myeloid leukemia had returned or did not respond to prior treatments. The …

This study was the first time a new drug called SAR443579 was tested in people. It aimed to find a safe dose and see if it could help control several aggressive blood cancers that had come back or stopped responding to other treatments. The trial included both adults and children…

This study tested whether an injectable medication called amlitelimab could reduce painful lumps and abscesses in adults with moderate to severe hidradenitis suppurativa (HS), a chronic inflammatory skin disease. About 90 participants received either the drug or a placebo injecti…

This study aimed to see if starting treatment with the drug venglustat earlier could better slow kidney growth and preserve function in people with a genetic form of rapidly progressive kidney disease (ADPKD). It was an extension study for 24 participants who had completed a prev…

This study aimed to see if a preventive treatment for moderate or severe hemophilia A helps patients achieve personal goals and become more physically active. It planned to observe 35 patients aged 12-50 in the US and Japan who were newly starting this treatment. The study was te…

This study tested whether adding a new drug called isatuximab to standard chemotherapy could help children whose acute leukemia had come back or not responded to previous treatment. It involved 67 children and young adults, from infants to under 18 years old. The main goal was to…

This early-stage study tested a new two-drug combination (SAR444245 with cemiplimab) for people with advanced melanoma or squamous cell skin cancer that had spread and could not be removed by surgery. The main goal was to see if the combination could shrink tumors and determine a…

This study tested whether a new oral drug called amcenestrant could better control advanced breast cancer compared to standard hormone therapy. It involved 367 adults whose cancer had worsened despite prior hormone treatments. The goal was to see if the new drug could delay cance…

This was an early-stage trial testing a new drug called SAR441000, which was injected directly into tumors. It aimed to find a safe dose and see if the drug, given alone or with another cancer therapy (cemiplimab), could help control advanced cancers in patients who had no other …

This study tested the safety and early signs of effectiveness of a two-drug combination (isatuximab plus cemiplimab) for people with certain lymphomas that had returned or stopped responding to prior treatments. It involved 58 participants with Hodgkin's lymphoma, diffuse large B…

This study tested a drug called isatuximab in people waiting for a kidney transplant. The goal was to see if the drug could safely help reduce harmful antibodies in patients' blood, making them better matches for more donor kidneys. The trial was small and has been terminated, so…

This early-stage study tested a new drug called SAR444200, given alone or with other cancer treatments, in adults with advanced solid tumors that had progressed after standard care. The main goals were to find a safe dose and see if the drug showed any signs of fighting the cance…

This study aimed to see if a new drug called amcenestrant was better than the standard drug tamoxifen at keeping early-stage, hormone-sensitive breast cancer from coming back. It was for patients who had to stop their initial hormone therapy due to side effects. The trial was des…

This study tested an experimental drug, tusamitamab ravtansine, in people with advanced breast or pancreatic cancer that had spread. The drug is designed to target and deliver chemotherapy directly to cancer cells that have a specific marker called CEACAM5. The trial aimed to see…

This study aimed to understand how liver function affects the processing of the breast cancer drug amcenestrant. It involved 13 female participants, some with mild to moderate liver impairment and others with normal liver function, who received a single dose. The main goal was to…