Myasthenia gravis drug trial halted early – only 6 patients enrolled
NCT ID NCT05132569
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested tolebrutinib, an oral drug, in adults with moderate-to-severe generalized myasthenia gravis. The trial was a Phase 3, double-blind, placebo-controlled study that planned to enroll many participants but was terminated early with only 6 people enrolled. Because it stopped so early, there is no reliable information on whether tolebrutinib helps or is safe for this condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tolebrutinib (oral tablet)
What could go wrong
The trial was terminated early with only 6 participants, so no conclusions can be drawn about safety or effectiveness. This drug may not work for myasthenia gravis.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Georgetown University-Site Number:8400008
Washington D.C., District of Columbia, 20007, United States
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Harvard Medical School - Brigham and Women's Hospital-Site Number:8400004
Boston, Massachusetts, 02115, United States
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Investigational Site Number :1240003
London, Ontario, N6A 5A5, Canada
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Investigational Site Number :1240004
Edmonton, Alberta, T6G 2B7, Canada
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Investigational Site Number :1560001
Shanghai, 200040, China
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Investigational Site Number :1560002
Wuhan, 430030, China
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Investigational Site Number :1560003
Chengdu, 610041, China
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Investigational Site Number :3480001
Szeged, 6725, Hungary
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Investigational Site Number :3480002
Pécs, 7623, Hungary
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Investigational Site Number :3800001
Milan, 20132, Italy
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Investigational Site Number :3800002
Milan, Lombardy, 20133, Italy
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Investigational Site Number :3800003
Roma, 00168, Italy
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Investigational Site Number :3800004
Naples, 80131, Italy
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Investigational Site Number :3920002
Sagamihara-shi, Kanagawa, 252-0392, Japan
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Investigational Site Number :6160001
Zabrze, 41-800, Poland
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Investigational Site Number :7240003
L'Hospitalet de Llobregat, Catalunya [Cataluña], 08907, Spain
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Investigational Site Number :7240005
Madrid, Madrid, Comunidad de, 28046, Spain
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Investigational Site Number :8260001
Liverpool, L9 7LJ, United Kingdom
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Investigational Site Number :8260002
Exeter, Devon, EX2 5DW, United Kingdom
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Neurology Center of San Antonio, PA-Site Number:8400009
San Antonio, Texas, 00000, United States
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SFM Clinical Research, LLC-Site Number:8400006
Boca Raton, Florida, 33487, United States
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University of South Florida Health- Morsani Center for Advanced Healthcare-Site Number:8400001
Tampa, Florida, 33612-6601, United States