New One-Shot meningitis vaccine shows promise in large trial
NCT ID NCT04368429
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This Phase 3 trial tested a new single-dose vaccine (MenACYW) against an existing one (Menactra) in 360 healthy people aged 2 to 55. The goal was to see if the new vaccine triggers a similar or better immune response to four types of meningococcal bacteria. Results showed the new vaccine was non-inferior, meaning it worked as well as the current vaccine, with a similar safety profile.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Meningococcal conjugate vaccine (MenACYW)
What this could lead to
If successful, this could provide a new option for a single-dose vaccine to protect against four types of meningococcal bacteria that cause meningitis and bloodstream infections.
What could go wrong
This is a completed Phase 3 trial, but the vaccine is still investigational and not yet approved. The study only included healthy volunteers, so results may not apply to people with weakened immune systems.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Investigational Site Number 3920001
Koganeishi, Japan
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Investigational Site Number 3920002
Shinjuku-Ku, Japan
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Investigational Site Number 3920003
Shinjuku-Ku, Japan
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Investigational Site Number 3920004
Nagoya, Japan