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New meningitis booster shows promise in phase 3 trial

NCT ID NCT04084769

Completed ⭐️ VACCINE ⭐️ Sponsor: Sanofi Pasteur, a Sanofi Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a booster dose of an experimental meningitis vaccine (MenACYW) in 570 healthy teens and adults who had received a meningitis vaccine 3-6 years earlier. The goal was to see if the booster could restore strong immunity against four types of meningococcal bacteria. Results will help determine if this vaccine can be used as a booster to maintain protection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Meningococcal polysaccharide (serogroups A, C, Y, and W) tetanus toxoid conjugate vaccine (MenACYW)

What this could lead to

If successful, this could provide a safe and effective booster option to maintain protection against meningococcal disease in adolescents and adults.

What could go wrong

This is a completed Phase 3 trial, so results are already in. However, the vaccine is still investigational and may not be approved or widely available. Side effects are possible, as with any vaccine.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

meningococcal infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENINGOCOCCAL IMMUNISATION (HEALTHY VOLUNTEERS)

Contacts and locations

Locations

  • Investigational Site Number 6300001

    San Juan, 00981, Puerto Rico

  • Investigational Site Number 8400001

    Layton, Utah, 84041, United States

  • Investigational Site Number 8400002

    Lincoln, Nebraska, 68505, United States

  • Investigational Site Number 8400003

    Salt Lake City, Utah, 84107, United States

  • Investigational Site Number 8400004

    Lincoln, Nebraska, 68516, United States

  • Investigational Site Number 8400005

    San Diego, California, 92123-1881, United States

  • Investigational Site Number 8400007

    Salt Lake City, Utah, 84109, United States

  • Investigational Site Number 8400009

    Norman, Oklahoma, 73069, United States

  • Investigational Site Number 8400011

    Provo, Utah, 84064, United States

  • Investigational Site Number 8400012

    Birmingham, Alabama, 35205, United States

  • Investigational Site Number 8400013

    Bardstown, Kentucky, 40004, United States

  • Investigational Site Number 8400014

    Layton, Utah, 84041, United States

  • Investigational Site Number 8400015

    South Jordan, Utah, 84095, United States

  • Investigational Site Number 8400018

    Kingsport, Tennessee, 37660, United States

  • Investigational Site Number 8400022

    Salt Lake City, Utah, 84109, United States

  • Investigational Site Number 8400023

    Roy, Utah, 84067, United States

  • Investigational Site Number 8400024

    West Jordan, Utah, 84088-8865, United States

  • Investigational Site Number 8400027

    Lincoln, Nebraska, 68504, United States

  • Investigational Site Number 8400028

    South Euclid, Ohio, 44121, United States

  • Investigational Site Number 8400029

    Tullahoma, Tennessee, 37388, United States

  • Investigational Site Number 8400030

    Dayton, Ohio, 45414, United States

  • Investigational Site Number 8400031

    Kaysville, Utah, 84037, United States

  • Investigational Site Number 8400032

    Syracuse, Utah, 84075-9645, United States

  • Investigational Site Number 8400033

    Lexington, Kentucky, 40517, United States

  • Investigational Site Number 8400034

    Bridgeton, Missouri, 63044, United States

  • Investigational Site Number 8400036

    South Jordan, Utah, 84095, United States

  • Investigational Site Number 8400037

    Charlottesville, Virginia, 22903, United States

  • Investigational Site Number 8400038

    Erie, Pennsylvania, 16505, United States

  • Investigational Site Number 8400039

    Charleston, South Carolina, 29414, United States

  • Investigational Site Number 8400040

    Orem, Utah, 84057, United States