SMALL CELL LUNG CANCER

This early-stage study is testing a new drug called NMS-03305293 combined with an existing chemotherapy drug (temozolomide) for people with small cell lung cancer that has returned after previous treatments. The main goal is to check if this combination is safe and tolerable for …

This study is testing an experimental drug called ifinatamab deruxtecan (I-DXd) for people whose small cell lung cancer has returned after initial treatment. It will compare I-DXd against standard treatments chosen by doctors to see which works better at shrinking tumors and help…

This study is testing the safety and initial effectiveness of a new two-drug combination (YL201 plus ivonescimab) for people with advanced solid tumors, including specific types of lung cancer. The main goals are to find the safest dose and see if the treatment can shrink tumors.…

This study is testing a new drug, ABBV-706, combined with an existing immunotherapy (atezolizumab) for people with a fast-spreading type of lung cancer who haven't had treatment yet. Researchers want to find the best dose, see if it's safe, and check if it works better than the c…

This early-stage study is testing a new drug called BL-M14D1 in 120 patients with advanced small cell lung cancer and other neuroendocrine cancers that have spread and stopped responding to standard treatments. The main goals are to find the safest dose and see how the body proce…

This study is testing whether a new combination of two drugs, ZG006 and ZG005, is safe and effective for people with advanced small cell lung cancer or neuroendocrine carcinoma. It will involve about 350 adult participants to see if the drug combo can shrink tumors and control th…

This study is testing whether adding a new drug called tarlatamab to standard chemotherapy and immunotherapy helps people with advanced small-cell lung cancer live longer. Researchers will compare two treatment combinations in 330 participants who haven't received prior treatment…

This study is testing a new combination of four drugs as the first treatment for people with an advanced, fast-growing type of lung cancer. The goal is to see if adding a tablet called chidamide to standard chemotherapy and an immunotherapy drug can help control the cancer for lo…

This study is testing whether people with a specific type of lung cancer can be safely monitored at home after receiving a new drug treatment, instead of staying in the hospital. Researchers want to see if a 'Hospital-at-Home' program using telehealth is a more efficient way to w…

This study is testing whether a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. It will measure how many participants are still alive 6 months after receiving the treatment. Th…

This early-stage study is testing a new drug called ZG006 for people with advanced small cell lung cancer or neuroendocrine carcinoma who have no standard treatments left or cannot tolerate them. The main goals are to find a safe dose, check for side effects, and see if the drug …

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This study is testing whether a drug called onvansertib can help people with small cell lung cancer that has returned after chemotherapy. Researchers will give the drug to 37 patients who have already tried one or two chemotherapy treatments. They want to see if the drug shrinks …

This early-stage study is testing the safety and effectiveness of combining two or three experimental drugs for people with extensive stage small cell lung cancer. It will enroll about 200 adults whose cancer has progressed after standard treatment or who are newly diagnosed. The…

This study is testing whether adding a new drug called cirtuvivint to standard chemotherapy can better control small cell lung cancer that has returned after initial treatment. It will enroll about 42 adults whose cancer has progressed after prior platinum-based chemotherapy. The…

This study is testing a new drug called IDE849 for people with certain aggressive cancers, including small cell lung cancer, that have a specific marker called DLL3. The research aims to find safe doses and see if the drug can shrink tumors, either alone or combined with other me…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This program provides eligible patients with small cell lung cancer access to the investigational drug ABBV-706 before it is officially approved. A doctor must determine if the potential benefit outweighs the risks for each individual patient. The program is not for patients who …

This early-stage study aims to find a safe dose for combining a drug called talazoparib with low-dose chest radiation. It is for people with extensive-stage small cell lung cancer whose disease has not worsened after initial chemotherapy. The main goal is to see how well patients…

This is the first study in people to test a new oral drug called NKT3964. It aims to see if the drug is safe and can help control advanced cancers that have spread and stopped responding to standard treatments. The study will enroll adults with specific advanced solid tumors, inc…

This study is testing whether an experimental drug called ZG006 helps people with relapsed small cell lung cancer live longer than standard chemotherapy. The trial will enroll 420 adults whose cancer has returned after previous treatment. Researchers will directly compare ZG006 a…

This study is testing a new drug called GV20-0251 for adults with advanced solid tumor cancers that have progressed despite standard treatments. The first part aims to find a safe dose, and the second part will see how well the drug works against several types of cancer, includin…

This is a first-in-human study to test a new investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard therapies. The main goals are to find a safe dose, understand the drug's side effects, and see how…

This early-stage trial is testing whether adding an existing drug called acetazolamide to standard radiation and chemotherapy can better control small cell lung cancer. The drug may work by targeting the cancer's energy supply and making the tumor environment less acidic, which c…

This study is testing new drug combinations for people with extensive-stage small cell lung cancer that has returned or stopped responding to prior treatment. Researchers want to see if using new immunotherapy drugs alone or together is safe and can shrink or eliminate tumors. Th…

This early-stage trial is testing a new cancer drug called NN3201 for the first time in people. The study aims to find a safe dose and see how well the drug works against several advanced solid tumors that have a specific protein called c-Kit. Researchers will enroll 67 adults wi…

This study is testing whether a new drug called AK112 can help keep small cell lung cancer from coming back in people who have just finished their initial chemo-radiation treatment. About 560 participants will be randomly assigned to receive either the real drug or a placebo (ina…

This study is testing whether a new drug called ZL-1310 works better than standard treatments for people whose small cell lung cancer has returned after initial therapy. About 480 adults with relapsed cancer will be randomly assigned to receive either the new drug or their doctor…

This is the first study in people to test a new drug called BL-B01D1. It aims to find a safe dose and see if it can help control advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 470 adults with various solid tumors, including lung, br…

This study compares two radiation methods for patients whose cancer has spread to the brain and who are receiving immunotherapy. Researchers want to see if giving smaller radiation doses over several days causes fewer side effects than the standard single-day treatment. The trial…

This is the first study in people to test a new drug called BL-M14D1 for advanced cancers that have spread or cannot be removed by surgery. The main goal is to find a safe dose and see how the body processes the drug in about 22 adults with certain cancers, including small cell l…

This study is testing if adding a short, intense course of targeted radiation to standard immunotherapy and chemotherapy helps people with extensive-stage small cell lung cancer live longer without their cancer getting worse. It is for adults newly diagnosed with this aggressive …

This is the first study in people to test a new cancer drug called KIVU-107. The main goal is to find a safe dose and see how well the body handles it. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery and have stopped responding to avai…

This early-stage trial is testing a new intravenous drug called ST-001 for people with small cell lung cancer that has returned or stopped responding to standard treatments. The main goals are to find the highest safe dose and understand how the drug moves through the body. Resea…

This study is testing a new drug called ZG006 for people with advanced small cell lung cancer or other neuroendocrine cancers. The first part aims to find a safe dose, and the second part will see how well the drug works at controlling the cancer. Researchers will measure how man…

This study is testing whether a drug called tarlatamab can help people with a specific type of lung cancer stay in remission longer after their initial treatment. It will involve about 400 adults whose cancer has not gotten worse after standard chemotherapy and radiation. The mai…

This study is testing an oral drug called alisertib for people with advanced small cell lung cancer that has worsened after standard chemotherapy and immunotherapy. The main goal is to see if the drug can shrink tumors and control the cancer's growth, and to identify which patien…

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This study is testing two new drugs, BL-B01D1 and SI-B003, given alone and together, for people with advanced small cell lung cancer that has spread. The main goal is to see if these treatments shrink tumors and are safe for patients. It will enroll about 100 adults whose cancer …

This is the first human study of an experimental drug called JANX008 for people with advanced solid tumors that have spread and stopped responding to standard treatments. The main goal is to find a safe dose and understand how the body handles the drug. Researchers will also look…

This study is testing a new type of imaging scan to see if it can safely and effectively detect small cell lung cancer and similar tumors. The scan uses a special tracer that attaches to a protein called DLL3, which is often found on these cancer cells. Researchers want to see if…

This study is testing if a very powerful 7T MRI scanner can detect tiny brain tumors earlier than standard MRI scanners in people with small-cell lung cancer. It involves 20 patients who have chosen not to receive preventive brain radiation. Researchers will compare the 7T scan r…

This study aims to learn more about small cell lung cancer by analyzing patients' tumor tissue and blood samples. Researchers will collect these samples while patients receive their standard cancer treatments. The goal is to identify biological markers that could help predict tre…

This study aims to collect tissue samples from adults with various lung and thymic cancers to better understand these diseases. Researchers will analyze blood, tumor, and other samples from up to 2000 participants to learn how these cancers develop and respond to treatment. The g…