Could a cheap altitude pill boost lung cancer treatment?
NCT ID NCT03467360
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests whether adding acetazolamide (a drug used for altitude sickness) to standard chemoradiation or radioimmunotherapy can help treat small cell lung cancer. About 27 adults with either localized or extensive small cell lung cancer will receive the combination to find the safest dose and check for early signs of benefit. The idea is that acetazolamide may reduce tumor acidity, potentially making radiation and immunotherapy work better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acetazolamide (a drug that blocks carbonic anhydrase enzymes, often used for altitude sickness or glaucoma)
What this could lead to
If it works, this could point toward a new way to make standard cancer treatments more effective for small cell lung cancer by targeting tumor acidity.
What could go wrong
This is a very early Phase 1 trial with only 27 participants, so it is primarily testing safety and dosing. The drug may not improve outcomes or could add side effects without benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre Antoine Lacassagne
RECRUITINGNice, 06189, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Princesse grace
TERMINATEDMonte Carlo, Monaco