Centre Antoine Lacassagne

This early-phase trial tests whether adding acetazolamide (a drug used for altitude sickness) to standard chemoradiation or radioimmunotherapy can help treat small cell lung cancer. About 27 adults with either localized or extensive small cell lung cancer will receive the combina…

This phase 2 trial is testing whether adding a precise, high-dose radiation boost (CyberKnife) after standard chemoradiation can help keep locally advanced non-small cell lung cancer from progressing. About 42 patients who cannot have surgery will receive the boost. The main goal…

This study tests whether using virtual reality before proton therapy sessions can reduce stress and improve positioning in children aged 7 to 18 with cancer. Researchers will compare positioning time and anxiety levels when kids use VR versus standard care. The goal is to find a …

This study is testing a new way to give radiation therapy during breast cancer surgery for women aged 65 and older with early-stage breast cancer. The goal is to see if this approach is safe and causes fewer side effects. About 40 participants will receive the treatment and be mo…

This study tests whether using a frozen glove plus a tight surgical glove on one hand works better than a frozen glove alone to prevent nerve damage caused by the chemotherapy drug paclitaxel. About 60 women with early-stage breast cancer will be enrolled, each acting as their ow…

This study aims to build a large biobank of blood samples from 40,000 cancer patients to help identify biomarkers that can predict survival and response to treatment. Participants provide an extra 36ml of blood during routine blood draws. The samples will be used in future resear…

This study is testing whether special PET scans can predict early on if immunotherapy (with or without chemotherapy) is working in people with advanced non-small cell lung cancer. Researchers will scan 200 patients before treatment, then at 6 and 12 weeks, looking for signs that …

This study aims to find a unique chemical pattern (metabolomic signature) in blood, urine, and tumor samples from 250 people with upper aerodigestive tract cancers. By analyzing these samples before and after treatment, researchers hope to improve early detection, predict treatme…

This study takes tumor samples from 50 patients with specific gene mutations to grow tiny 3D cell clusters called spheroids in the lab. These spheroids help researchers test how well new or existing cancer drugs work against tumors with those mutations. The samples are collected …