Centre Antoine Lacassagne

This study tests whether adding the targeted drug pazopanib to standard chemotherapy (temozolomide) can safely control glioblastoma, an aggressive brain cancer. About 51 adults who had surgery and chemoradiation will receive the combination. The main goal is to find the best dose…

This study aimed to test the safety and effectiveness of combining the drug ribociclib with hormone therapy and radiation for women aged 70 and older with a certain type of breast cancer. The goal was to control the disease without surgery. However, the study was withdrawn before…

This study tests a new combination of two drugs (gemtuzumab ozogamicin and gilteritinib) for adults with a specific genetic form of acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial aims to see if the combination is safe and helps control th…

This study tests whether a special type of internal radiation (contact X-ray brachytherapy) given after standard chemoradiation can help more people with early rectal cancer keep their rectum, compared to standard external beam radiation. About 148 adults with small, early-stage …

This study tests whether a PET scan can measure brain blood vessel response to a drug called acetazolamide as well as the standard scintigraphy method. Nineteen adults with narrowed brain arteries will undergo both scans. The goal is to see if the newer PET approach is a reliable…

This study looks at how the activity of an enzyme called DPD influences how well the chemotherapy drug capecitabine works in women with metastatic breast cancer. Researchers will measure DPD activity before treatment and track tumor response over 24 months. The goal is to see if …