Centre Antoine Lacassagne

This study tested a single, high-dose radiation treatment for men with low-risk prostate cancer. The goal was to see how well patients tolerated the procedure and what side effects occurred within the first 6 months. 35 patients received the treatment, and researchers monitored u…

This early-phase study tested a new approach for women with breast cancer who cannot have breast-conserving surgery. It combined a short course of high-dose radiation (CyberKnife) with standard chemotherapy drugs. The main goal was to find the safest radiation dose and check for …

This study tested a new way to give an extra dose of radiation (a boost) to the tumor site after standard breast radiation. Instead of multiple sessions, the CyberKnife machine delivered a single high dose very precisely, aiming to reduce skin damage and improve cosmetic results.…

This study tested whether adding a precise, high-dose radiation treatment (CyberKnife) after standard chemo and radiation could improve outcomes for people with stage III non-small cell lung cancer. It involved 35 patients whose tumors had not spread but could not be removed by s…

This study tested a combination of chemotherapy, radiation, and a targeted drug called cetuximab in 53 patients with head and neck cancer who had a high risk of the cancer coming back after surgery. The goal was to see if this triple therapy could keep the cancer from returning f…

This study tested three different nutrition plans given through a feeding tube after surgery for head and neck cancer. The goal was to see which plan best prevents infections. The trial included 311 adults scheduled for tumor removal. Results help guide post-surgery care to reduc…

This early-phase study tested a combination of three drugs (gemcitabine, capecitabine, and erlotinib) in 30 people with advanced pancreatic cancer that had already been treated. The main goal was to find the safest dose and understand side effects. This is not a cure, but a way t…

This study tested a combination of chemotherapy (CHOP), a targeted antibody (rituximab), and a radioactive antibody (Y90 ibritumomab tiuxetan) in 30 adults aged 65-80 with newly diagnosed large B-cell lymphoma. The goal was to see if this approach could improve event-free surviva…

This study looked at how well MRI scans can measure the size of ductal carcinoma in situ (DCIS), a very early form of breast cancer. Forty women with DCIS had an MRI before surgery, and the MRI results were compared to the actual tumor size found during surgery. The goal was to s…

This study looked at 100 people with advanced lung cancer or melanoma who were getting immunotherapy. Researchers used a special PET scan to see if they could tell the difference between real tumor growth and inflammation that looks like growth. The goal was to improve how doctor…

This study looked at whether a special PET scan using 18F-FDOPA can help doctors decide on the best treatment for people with brain tumors (gliomas or metastases) when MRI results are unclear. 85 patients were enrolled. The goal was to see if the PET scan increased doctors' confi…

This study looked at whether two phone calls during the first three rounds of chemotherapy could help patients with breast or colon cancer feel less anxious and manage side effects better. About 274 patients took part, and researchers measured their mood, quality of life, and sid…

This study tested two ways to mark small, non-palpable breast tumors before surgery: a tiny radioactive seed (iodine-125) versus a standard metal wire. 350 women with early-stage breast cancer took part. The goal was to see if the seed method helps surgeons remove the tumor compl…

This study followed 76 adults over 70 with solid tumors to see how their quality of life changed during chemotherapy. Researchers used simple questionnaires about daily activities and mental health to understand each person's needs. The goal was to learn how to better tailor canc…

This study looked at how cancer treatment changes patients' sense of taste and smell, and how that affects their ability to follow a Mediterranean diet. Researchers followed 116 cancer patients before and after 9 weeks of treatment, comparing those with sensory changes to those w…

This study looked at whether a genetic condition called DPD deficiency can predict severe side effects from the chemotherapy drug capecitabine in women with metastatic breast cancer. Researchers analyzed blood samples from 303 participants to see if those with the deficiency had …

This study examined 52 breast cancer tumor samples and some blood samples to find unique metabolic patterns. The goal was to better understand different types of breast cancer and discover possible markers for diagnosis or treatment targets. Participants were women who had surger…

This study tested whether a costly PET scan called 18F-FDOPA helps doctors make better treatment choices for people with high-grade gliomas, a type of aggressive brain tumor. About 110 patients whose cases were discussed by a team of brain-tumor specialists took part. The main go…

This study looked at how often cancer patients develop dangerous blood clots, especially those who also have bleeding problems or take blood thinners. Researchers followed 700 hospitalized cancer patients to track clot rates and understand risk factors. The goal was to gather inf…

This study tested a new way to give radiation therapy during breast cancer surgery (called intraoperative radiotherapy) in 28 women aged 60 or older with early-stage breast cancer. The goal was to see if the technique could deliver the right dose of radiation to the tumor area sa…

This study looked at 422 breast cancer patients to understand how their knowledge about exercise, their current activity level, and their fatigue affect their beliefs about physical activity and their desire to be active. The goal was to learn what influences their motivation, no…

This study followed 240 people with head and neck cancer to see how their first treatment affected their ability to swallow. Researchers used a special questionnaire and doctor exams to track swallowing problems from diagnosis up to 18 months after treatment. The goal was to unde…

This study aimed to find out how many cancer patients had COVID-19, including those without symptoms. Researchers used a rapid blood test to check for antibodies in 214 patients receiving cancer treatment. The goal was to better understand infection risks and help hospitals keep …

This study looked at whether having an extra talk with a radiotherapy technician helps cancer patients get better information about their treatment. Over 300 adults with various cancers took part. The goal was to see if this extra chat reduces anxiety and helps patients feel more…

This study looked at how common iron deficiency is in 480 cancer patients about to start chemotherapy. The goal was to find out how many might benefit from iron injections. No new treatments were tested; instead, researchers measured iron levels using blood tests to better unders…

This study looked at 160 people with head and neck cancer who needed a diagnostic exam called panendoscopy under general anesthesia. Researchers compared standard oxygen therapy with a high-flow system called THRIVE (Optiflow) to see which one better prevents drops in oxygen leve…