Centre Antoine Lacassagne

This study tested a treatment plan for adults aged 65 to 80 with a type of lymphoma (large B-cell). The plan combined standard chemotherapy with targeted antibodies and a radioactive drug. The goal was to see if this approach could better control the cancer. The study involved 30…

This early-phase study tested a combination of three drugs (gemcitabine, capecitabine, and erlotinib) in 30 people with advanced pancreatic cancer that had already been treated. The main goal was to find the safest dose and understand side effects. This is not a cure, but aims to…

This study tested a single, high-dose radiation treatment for men with low-risk or low intermediate-risk prostate cancer. The goal was to see how well the body tolerates this one-time treatment by tracking side effects in the bladder and digestive system within the first 6 months…

This study tested whether a single, precise dose of radiation from a CyberKnife robot could replace multiple standard boost treatments after whole-breast radiation in 29 women with early-stage breast cancer. The goal was to reduce skin side effects like redness and swelling while…

This study tested whether adding a precise, high-dose radiation treatment called CyberKnife after standard chemo and radiation could help people with stage III non-small cell lung cancer. It included 35 patients who had 1 to 3 small tumors left after initial treatment. The goal w…

This early-phase study tested a new approach for women with breast cancer that cannot be removed by surgery alone. It combined a short course of high-dose radiation (CyberKnife) with standard chemotherapy drugs. The main goal was to find the safest radiation dose and check for si…

This phase II trial tested whether adding the targeted drug cetuximab to standard chemotherapy and radiation could help prevent head and neck cancer from coming back after surgery. The study enrolled 53 patients with certain high-risk features. The main goal was to see how many p…

This phase 3 trial tested whether giving a special nutritional supplement (immunonutrition) before and after surgery could reduce infections in 311 patients with head and neck cancer. Participants were randomly assigned to one of three nutrition regimens. The main goal was to see…

This study looked at whether MRI can more accurately measure the size of ductal carcinoma in situ (a very early form of breast cancer) compared to standard mammography. Forty women with the condition had MRI scans before surgery. Researchers then compared the MRI results with the…

This study looked at whether a special PET scan using 18F-FDOPA can help doctors make better treatment decisions for people with brain tumors (gliomas or metastases) when standard MRI results are unclear. 85 patients whose MRI scans were inconclusive received this PET scan, and r…

This study looked at whether a special PET scan (18FDG dual-point) can tell the difference between real tumor growth and harmless inflammation caused by immunotherapy. Researchers studied 100 people with advanced lung cancer or melanoma who were being treated with drugs like nivo…

This study tested a quick finger-prick blood test to see if cancer patients had been infected with COVID-19 in the past. Researchers enrolled 214 adults being treated for cancer. The goal was to find out how many had antibodies, including those without symptoms, to help clinics k…

This study tested whether two nurse phone calls during the first three cycles of chemotherapy could improve the emotional state and quality of life of patients with breast, colon, or rectal cancer. 274 patients were randomly assigned to receive either standard care or standard ca…

This study tested two methods for marking non-palpable breast tumors before surgery: a tiny iodine seed versus a standard metal wire. 350 women with early-stage breast cancer took part. The goal was to see if the seed method leads to cleaner surgical margins, potentially reducing…

This study tested a device called Papillon +TM that delivers a single dose of radiation directly to the tumor site during breast cancer surgery. 28 women aged 60 and older with early-stage breast cancer took part. The main goal was to see if the technique was feasible and safe, n…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study followed 110 people with anal cancer to see if PET/CT scans can help doctors monitor the disease after initial treatment. Researchers tracked how long patients stayed cancer-free and measured metabolic activity in tumors. The goal is to find better ways to detect relap…

This study examined blood samples from 49 women with metastatic breast cancer to find genetic markers that predict side effects from trastuzumab (Herceptin). The goal was to understand why some patients experience heart or allergic reactions. It did not test a new treatment, but …

This completed study looked at whether a deficiency in the DPD enzyme can predict severe side effects from the chemotherapy drug capecitabine in women with metastatic breast cancer. Researchers analyzed blood samples from 303 participants to see if genetic differences could help …

This study looked at how cancer treatment changes patients' ability to stick with a Mediterranean diet. Researchers followed 116 patients starting chemotherapy or immunotherapy, checking their diet adherence and sensory changes (taste and smell) at the start and after 9 weeks. Th…

This study looked at how common iron deficiency is in cancer patients starting chemotherapy. Researchers checked iron levels in 480 adults with solid tumors or lymphoma. The goal was to find out how many patients might benefit from iron injections, without using other drugs like …

This study tested whether an 18F-FDOPA PET scan changes treatment decisions for people with high-grade gliomas (aggressive brain tumors) when standard MRI results are unclear. Researchers enrolled 110 patients and compared treatment plans before and after the scan. The goal was t…

This study looked at 160 people with head and neck cancer who needed a diagnostic scope (panendoscopy) under anesthesia. Researchers compared standard oxygen therapy with a high-flow system called THRIVE to see which one better prevents drops in oxygen levels. The goal is to find…

This study followed 76 cancer patients over age 70 to see how geriatric tests and social factors affect their quality of life. Researchers wanted to learn how to better tailor chemotherapy and care for older adults. The goal was to improve both well-being and cost-effectiveness o…

This study looked at 700 cancer patients to understand how often dangerous blood clots occur and how blood-thinning medications affect them. Researchers tracked patients over two years, analyzing blood samples and clotting events. The goal is to improve prevention and treatment o…

This study followed 240 people with head and neck cancer to see how their swallowing changed from diagnosis to 18 months after their first treatment. Researchers used a questionnaire called the Deglutition Handicap Index (DHI) to measure patients' own experience of swallowing pro…

This study looked at 422 breast cancer patients to understand what influences their beliefs about physical activity and their desire to be active. Researchers measured patients' knowledge of exercise benefits, their current activity levels, and fatigue. The goal was to learn how …

This study looked at small molecules called metabolites in breast cancer tumors to find patterns that could help understand the disease better. Researchers analyzed 52 tumor samples and some blood samples from patients who had surgery. The goal was to identify possible biomarkers…