New antibody drug aims to stop lung cancer relapse in its tracks

NCT ID NCT07010263

Recruiting now Disease control Sponsor: Akeso Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing whether AK112 (Ivonescimab), a bispecific antibody that targets both PD-1 and VEGF, can help prevent cancer progression in people with limited-stage small-cell lung cancer who have completed chemoradiation. About 560 participants will receive either AK112 or a placebo every three weeks. The study measures how long patients live without their cancer worsening and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AK112 (Ivonescimab), a bispecific antibody targeting PD-1 and VEGF
What this could lead to: If successful, this could provide a new consolidation treatment option to delay cancer progression and improve survival for patients with limited-stage small-cell lung cancer.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not improve outcomes over placebo, and side effects from immune activation or anti-VEGF effects could occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Affiliated Cancer Hospital of Guangxi Medical University
RECRUITING

Nanning, Guangxi, 530021, China
Anyang Cancer Hospital
RECRUITING

Anyang, Henan, 455000, China
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Beijing Chest Hospital
RECRUITING

Beijing, Beijing Municipality, 101149, China
Beijing Luhe Hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 101149, China
Cancer Hospital, Chinese Academy of Medical Sciences
RECRUITING

Beijin, Beijin, 100021, China
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Gansu Provincial Cancer Hospital
RECRUITING

Lanzhou, Gansu, 730050, China
General Hospital of the PLA Eastern Theater Command
RECRUITING

Nanjing, Jiangsu, 210002, China
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, Guangzhou, 510080, China
Guizhou Provincial People's Hospital
RECRUITING

Guiyang, Guizhou, 400042, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, Henan, 450008, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, 410013, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, 410013, China
Jiangmen Central Hospital
RECRUITING

Jiangmen, Guangdong, 529030, China
Jiangsu Cancer Hospital
RECRUITING

Nanjing, Jiangsu, 210009, China
Jilin Cancer Hospital
RECRUITING

Changchun, Jilin, 130000, China
Jingzhou First People's Hospital
RECRUITING

Jingzhou, Hubei, 434000, China
Linyi Cancer Hospital
RECRUITING

Linyi, Shandong, 276000, China
Linyi People's Hospital
RECRUITING

Linyi, Shandong, 276000, China
Liuzhou People's Hospital
RECRUITING

Liuzhou, Guangxi, 545006, China
Longyan First Hospital
RECRUITING

Longyan, Fujian, 364000, China
Mianyang Central Hospital
RECRUITING

Mianyang, Sichuan, 621000, China
Ningxia Medical University General Hospital
RECRUITING

Yinchuan, Ningxia, 750004, China
PLA No. 900 Hospital of the Joint Support Force
RECRUITING

Fuzhou, Fujian, 350025, China
Qingdao Central Hospital of Health and Rehabilitation Sciences University
RECRUITING

Qingdao, Shandong, 266000, China
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China
Shandong Provincial Hospital
RECRUITING

Jinan, Shandong, 250021, China
Shanghai Pulmonary Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200433, China
Shanxi Cancer Hospital
RECRUITING

Taiyuan, Shanxi, 300013, China
Tangdu Hospital, The Fourth Military Medical University
RECRUITING

Xi’an, Shanxi, 710038, China
Tangshan People's Hospital
RECRUITING

Tangshan, Hebei, 063001, China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Gannan Medical University
RECRUITING

Gannan, Jiangxi, 341000, China
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Nanning, Guangxi, 530021, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of South China University
RECRUITING

Hengyang, Hunan, 421001, China
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, 325000, China
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Shaxi, Xi'an, 710061, China
The First Affiliated Hospital of Xinxiang Medical University
RECRUITING

Xinxiang, Henan, 453100, China
The First Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, 110001, China
The First Medical Center of Chinese PLA General Hospital
RECRUITING

Beijing, Beijing Municipality, 100853, China
The Fourth Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 050011, China
The Second Affiliated Hospital of Harbin Medical University
RECRUITING

Harbin, Heilongjiang, 150086, China
The Second Affiliated Hospital of Zunyi Medical University
RECRUITING

Zunyi, Guizhou, 563000, China
Tianjin Cancer Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300060, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430022, China
Weifang No.2 People's Hospital
RECRUITING

Weifang, Shangdong, 261041, China
Xuzhou Municipal Hospital
RECRUITING

Xuzhou, Jiangsu, 221002, China
Zaozhuang Municipal Hospital
RECRUITING

Zaozhuang, Shandong, 277100, China
Zhangzhou Municipal Hospital of Fujian Province
RECRUITING

Zhangzhou, Fujian, 363000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.