New hope for tough lung cancer: targeted drug faces off against standard care

NCT ID NCT06203210

Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study tests a new drug called ifinatamab deruxtecan (I-DXd) against standard treatments for people whose small cell lung cancer has returned. About 540 adults with advanced disease will be randomly assigned to receive either I-DXd or a treatment chosen by their doctor. The goal is to see if I-DXd shrinks tumors and helps people live longer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

'Henry Dynant' Hospital Center
NOT_YET_RECRUITING

Athens, 11526, Greece
A. C. Camargo Cancer Center
NOT_YET_RECRUITING

São Paulo, 01509-900, Brazil
AZ DELTA
NOT_YET_RECRUITING

Roeselare, 8800, Belgium
AdventHealth Orlando, Cancer Institute
RECRUITING

Orlando, Florida, 32804, United States
Ajou University Hospital
RECRUITING

Suwon, 16499, South Korea
Ankara Bilkent City Hospital
RECRUITING

Ankara, 6800, Turkey (Türkiye)
Asan Medical Center
RECRUITING

Seoul, 5505, South Korea
Asklepios Fachkliniken Muenchen-Gauting
RECRUITING

Gauting, 82131, Germany
Asklepios Klinik Harburg
NOT_YET_RECRUITING

Hamburg, 21075, Germany
Assistance Publique-Hăpitaux de Marseille
RECRUITING

Marseille, 13005, France
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
Azienda Ospedaliera Di Perugia Ospedale S. Maria Della Misericordia
RECRUITING

Perugia, 06132, Italy
Azienda Ospedaliera Universitaria Policlinico - Vittorio Emanuele (Presidio Gaspare Rodolico)
NOT_YET_RECRUITING

Catania, 95123, Italy
Azienda Ospedaliera Universitaria- Universită Degli Studi Della Campania Âluigi Vanvitelliâ
RECRUITING

Naples, 80131, Italy
Azienda Ospedaliero Universitaria Di Parma
RECRUITING

Parma, 43100, Italy
Azienda Ospedaliero Universitaria Renato Dulbecco
RECRUITING

Catanzaro, 88100, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili)
NOT_YET_RECRUITING

Brescia, 25124, Italy
Azienda Socio Sanitaria Territoriale Di Monza (Presidio San Gerardo)
NOT_YET_RECRUITING

Monza, 20900, Italy
Ballarat Base Hospital
RECRUITING

Ballarat, 3350, Australia
Baptist Health Lexington
RECRUITING

Lexington, Kentucky, 40503, United States
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Beijing Chest Hospital,Capital Medical University
RECRUITING

Beijing, 101149, China
Bács-Kiskun Vármegyei Oktatókórház
RECRUITING

Kecskemét, 6000, Hungary
CHU de Saint Etienne
RECRUITING

Saint-Etienne, 42055, France
Cancercare Manitoba
RECRUITING

Winnipeg, R3E0V9, Canada
Centre Hospitalier Intercommunal de Crăteil
RECRUITING

Créteil, 94010, France
Centre Hospitalier Universitaire de Liege
RECRUITING

Liège, 4000, Belgium
Centre Léon Bérard
NOT_YET_RECRUITING

Lyon, 69008, France
Centro Hospitalar Do Porto, E.P.E. - Hospital de Santo António
RECRUITING

Porto, 4099-001, Portugal
Centro Hospitalar E Universitărio de Coimbra E.P.E.
RECRUITING

Coimbra, 3040, Portugal
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital Pulido Valente
RECRUITING

Lisbon, 1769-001, Portugal
Centro Ricerche Cliniche Di Verona S.R.L.
RECRUITING

Verona, 37134, Italy
Centrum Onkologii Im. Prof. F. Lukaszczyka W Bydgoszczy
RECRUITING

Bydgoszcz, 85-796, Poland
Cepho Centro de Estudos E Pesquisas de Hematologia E Oncologia
RECRUITING

Santo André, 09060-650, Brazil
Cepon - Centro de Pesquisas Oncolăgicas de Santa Catarina
RECRUITING

Florianópolis, 88034-000, Brazil
Ch de Mulhouse - Hăpital Emile Muller
RECRUITING

Mulhouse, 68100, France
Chang Gung Memorial Hospital
RECRUITING

Taoyuan City, 333, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 404327, Taiwan
China-Japan Friendship Hospital
RECRUITING

Beijing, 100029, China
Chongqing University Cancer Hospital
RECRUITING

Chongqing, 400030, China
Chris O Brien Lifehouse
RECRUITING

Camperdown, 2050, Australia
Chu Bordeaux
NOT_YET_RECRUITING

Bordeaux, 33075, France
Chu Limoges - Hopital Du Cluzeau
RECRUITING

Limoges, 87042, France
Chu Nantes - Hăpital Guillaume Et Renă Laănnec
NOT_YET_RECRUITING

Saint-Herblain, 44805, France
Chu Rennes - Hopital Pontchaillou
RECRUITING

Rennes, 35033, France
Chu Ucl Namur
RECRUITING

Yvoir, 5530, Belgium
Chungbuk National University Hospital
RECRUITING

Cheongju-si, 28644, South Korea
Cleveland Clinic Mercy Hospital
RECRUITING

Canton, Ohio, 44708, United States
Clinical Research Alliance, Inc
RECRUITING

Lake Success, New York, 11042, United States
Clinical Research Providence Medical Foundation
RECRUITING

Fullerton, California, 92835, United States
Cliniques Universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, 1200, Belgium
Clínica de Neoplasias Litoral
RECRUITING

Itajaí, 88301-220, Brazil
Complejo Hospitalario Universitario Insular Materno-Infantil
RECRUITING

Las Palmas de Gran Canaria, 35016, Spain
Cross Cancer Institute
RECRUITING

Edmonton, T6G 1Z2, Canada
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02216, United States
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03766, United States
Departmento de Pesquisa Clinica- Hospital de Amor de Barretos
RECRUITING

Barretos, 14784-400, Brazil
Dicle University, Medical Faculty
RECRUITING

Diyarbakır, 21080, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
RECRUITING

Ankara, 06105, Turkey (Türkiye)
Etz Elisabeth
RECRUITING

Tilburg, 5022 GC, Netherlands
Evangelische Lungenklinik Berlin
RECRUITING

Berlin, 13125, Germany
Fakultni Nemocnice Olomouc
RECRUITING

Olomouc, 77900, Czechia
Fakultni Thomayerova Nemocnice
RECRUITING

Prague, 140 59, Czechia
Flinders Medical Centre (Fmc)
RECRUITING

Bedford Park, 5042, Australia
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, 200032, China
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
RECRUITING

São José do Rio Preto, 15090-000, Brazil
General Hospital of Athens Alexandra
NOT_YET_RECRUITING

Athens, 11528, Greece
General Hospital of Athens of Chest Diseases 'Sotiria'
RECRUITING

Athens, 11527, Greece
General Hospital of Patra Agios Andreas
RECRUITING

Pátrai, 26335, Greece
Goztepe Prof Dr Suleyman Yalcin City Hospital
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
RECRUITING

Győr, 9024, Hungary
H. Lee Moffitt Cancer Center and Research Institute, Inc
NOT_YET_RECRUITING

Tampa, Florida, 33612, United States
Hackensack Meridian Health Jsumc
RECRUITING

Neptune City, New Jersey, 07753, United States
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING

Haerbin, 150081, China
Helios Klinikum Erfurt
RECRUITING

Erfurt, 99089, Germany
Henan Cancer Hospital
RECRUITING

Zhengzhou, 450008, China
Henry Ford Health System
NOT_YET_RECRUITING

Detroit, Michigan, 48202, United States
Hfr Fribourg/Kantonsspital Fribourg
RECRUITING

Villars-sur-Glâne, 1752, Switzerland
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Hopital Arnaud de Villeneuve
RECRUITING

Montpellier, 34295, France
Hopital Tenon
RECRUITING

Paris, 75020, France
Hospital Alemão Oswaldo Cruz
RECRUITING

São Paulo, 01327-001, Brazil
Hospital Beneficăncia Portuguesa de Săo Paulo
RECRUITING

São Paulo, 01321-001, Brazil
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Da Luz
RECRUITING

Lisbon, 1500-650, Portugal
Hospital Da Senhora Da Oliveira Guimarăes
RECRUITING

Guimarães, 4835-044, Portugal
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29010, Spain
Hospital Sirio-Libanes
NOT_YET_RECRUITING

São Paulo, 01308-050, Brazil
Hospital São Lucas Da Pucrs
RECRUITING

Porto Alegre, 90610-000, Brazil
Hospital Universitari Vall D'Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Ciudad de Jaen
NOT_YET_RECRUITING

Jaén, 23007, Spain
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Nuestra Señora de Valme
RECRUITING

Seville, 41014, Spain
Hospital Universitario Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Reina Sofia
RECRUITING

Córdoba, 14004, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital de Especialidades de Jerez de La Frontera
RECRUITING

Jerez de la Frontera, 11408, Spain
Hospital de La Santa Creu I Sant Pau
RECRUITING

Barcelona, 8025, Spain
Houston Methodist Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Huazhong University of Science and Technology - Tongji Medical College - Tongji Hospital Tjh
RECRUITING

Wuhan, 430030, China
Hubei Cancer Hospital
NOT_YET_RECRUITING

Wuhan, 430079, China
Humanitas Gavazzeni
RECRUITING

Bergamo, 24125, Italy
Hunan Cancer Hospital
RECRUITING

Changsha, 410013, China
Hăpital Foch
NOT_YET_RECRUITING

Suresnes, 92151, France
ICESP Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira
RECRUITING

São Paulo, 01246-000, Brazil
IEO Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Ico L'Hospitalet - Hospital Duran I Reynals
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Inselspital - Universitaetsspital Bern
RECRUITING

Bern, 3010, Switzerland
Institut Curie - Site de Paris
RECRUITING

Paris, 75005, France
Institut Cœur Poumon CHU de Lille
RECRUITING

Lille, 69037, France
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
Institut Régional Du Cancer de Montpellier
RECRUITING

Montpellier, 34298, France
Institut Sainte Catherine
RECRUITING

Avignon, 84000, France
Institut Universitaire de Cardiologie et de Pneumologie de Quebec
RECRUITING

Québec, G1V 4G5, Canada
Institut de Cancerologie de La Loire
RECRUITING

Saint-Priest-en-Jarez, 42270, France
Institutul Oncologic 'Prof. Dr. Ion Chiricuta' Cluj Napoca
NOT_YET_RECRUITING

Cluj-Napoca, 400015, Romania
Instytut Centrum Zdrowia Matki Polki
NOT_YET_RECRUITING

Lodz, 93-338, Poland
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Nazionale Per La Ricerca Sul Cancro Di Genova
RECRUITING

Genova, 16132, Italy
Istituto Nazionale Tumori Regina Elena Irccs
RECRUITING

Roma, 00144, Italy
Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari
RECRUITING

Bari, 70124, Italy
Izmir Medicalpark Hospital
NOT_YET_RECRUITING

Izmir, 35530, Turkey (Türkiye)
Jeroen Bosch Ziekenhuis
RECRUITING

's-Hertogenbosch, 5223 GZ, Netherlands
Jessa Ziekenhuis Hospital
RECRUITING

Hasselt, 3500, Belgium
Jilin Province Tumor Hospital
RECRUITING

Changchun, 130012, China
Johannes Wesling Klinikum Minden
NOT_YET_RECRUITING

Minden, 32429, Germany
John Hopkins School of Medicine
RECRUITING

Baltimore, Maryland, 21287, United States
Kansai Medical University Hospital
RECRUITING

Hirakata-shi, 573-1191, Japan
Kantonsspital St. Gallen
RECRUITING

Sankt Gallen, 9007, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Kepler University Hospital
RECRUITING

Linz, 4020, Austria
Kindai University Hospital
RECRUITING

Osaka-Sakai, 590-0197, Japan
Kitasato University Hospital
RECRUITING

Sagamihara, 252-0375, Japan
Klinik Floridsdorf
NOT_YET_RECRUITING

Vienna, 1210, Austria
Krajska Nemocnice Liberec A.S.
RECRUITING

Liberec, 460 63, Czechia
Krankenhaus Nordwest Gmbh
RECRUITING

Frankfurt, 60488, Germany
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, 41404, South Korea
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
Landesklinikum Krems
RECRUITING

Krems, 3500, Austria
Landeskrankenhaus Feldkirch
RECRUITING

Feldkirch, 6800, Austria
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health Long Island
RECRUITING

New York, New York, 10016, United States
Liaoning Cancer Hospital & Institute
RECRUITING

Shenyang, 110042, China
Linyi Cancer Hospital
RECRUITING

Linyi, 276001, China
Lki Lungenfachklinik Immenhausen
RECRUITING

Immenhausen, 34376, Germany
Maastricht University Medical Center
RECRUITING

Maastricht, 6229 HX, Netherlands
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy
RECRUITING

Otwock, 05-400, Poland
Medical College of Wisconsin
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medipol University Medical Faculty
RECRUITING

Istanbul, 34214, Turkey (Türkiye)
Mercy Clinic Oncology and Hematology Sindelar Cancer Center
RECRUITING

St Louis, Missouri, 63128, United States
Metropolitan Hospital
RECRUITING

Piraeus, 185 47, Greece
Montefiore Medical Center Prime
NOT_YET_RECRUITING

The Bronx, New York, 10461, United States
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277-8577, Japan
National Cheng Kung University Hospitalx
RECRUITING

Tainan, 70403, Taiwan
National Hospital Organization Hokkaido Cancer Center
RECRUITING

Sapporo, 003-0804, Japan
National Hospital Organization Shikoku Cancer Center
RECRUITING

Matsuyama, 791-0280, Japan
National Taiwan University Cancer Centre
RECRUITING

Taipei, 10048, Taiwan
Netherlands Cancer Institute
NOT_YET_RECRUITING

Amsterdam, 1066 CX, Netherlands
New York University Cancer Center - Laura and Isaac
RECRUITING

New York, New York, 10016, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Oncology/Hematology Care Clinical Trials, Llc
RECRUITING

Cincinnati, Ohio, 45236, United States
Orszagos Koranyi Pulmonologiai Intezet
RECRUITING

Budapest, 1121, Hungary
Orszagos Onkologiai Intezet
NOT_YET_RECRUITING

Budapest, 1122, Hungary
Osaka Medical and Pharmaceutical University Hospital
RECRUITING

Takatsuki, 569-8686, Japan
Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, 20132, Italy
Pius-Hospital Oldenburg
NOT_YET_RECRUITING

Oldenburg, 26121, Germany
Princess Alexandra Hospital
RECRUITING

Woolloongabba, 4102, Australia
Princess Margaret Cancer Center
RECRUITING

Toronto, M5G 2M9, Canada
Providence Portland Medical Center
NOT_YET_RECRUITING

Portland, Oregon, 97213, United States
Provita Prolife
RECRUITING

Tomaszów Mazowiecki, 97-200, Poland
Rush MD Anderson Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States
S.C Centrul de Oncologie Sfantul Nectarie Craiova
RECRUITING

Craiova, 200745, Romania
S.C Radiotherapy Center Cluj S.R.L
RECRUITING

Bucharest, 407280, Romania
S.C. Sigmedical Services Srl
NOT_YET_RECRUITING

Suceava, 720214, Romania
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Semmelweis Egyetem
NOT_YET_RECRUITING

Budapest, 1088, Hungary
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 3080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shandong Cancer Hospital
RECRUITING

Jinan, 250117, China
Shizuoka Cancer Center
RECRUITING

Nakatogari, 411-8777, Japan
Sichuan Cancer Hospital
RECRUITING

Chengdu, 610041, China
Srh Wald-Klinikum Gera Gmbh
RECRUITING

Gera, 7548, Germany
St John of God Subiaco Hospital
RECRUITING

Subiaco, 6008, Australia
St Luke'S Hospital
RECRUITING

Thessaloniki, 55236, Greece
Staedtisches Krankenhaus Kiel
RECRUITING

Kiel, 24116, Germany
Sunshine Hospital
RECRUITING

St Albans, 3021, Australia
Szpital Specjalistyczny W Prabutach
NOT_YET_RECRUITING

Prabuty, 82-550, Poland
THE WEST CLINIC, PLLC dba West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Medical University Hospital
RECRUITING

Taipei, 110301, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Texas Oncology, P.A. - Tyler
RECRUITING

Tyler, Texas, 75702, United States
The Affiliated Cancer Hospital of Xinjiang Medical University
RECRUITING

Ürümqi, 830000, China
The Cancer Institute Hospital of Jfcr
RECRUITING

Kōtoku, 135-8550, Japan
The Catholic University of Korea, St. Vincent'S Hospital
RECRUITING

Suwon, 16247, South Korea
The First Affiliated Hospital of Xiân Jiaotong University
RECRUITING

Xi'an, 710061, China
The First Affiliated Hospital, College of Medicine, Zhejiang University
RECRUITING

Hangzhou, 310003, China
The Second Affiliated Hospital of Nanchang University
RECRUITING

Jiangxi, 330030, China
The Second Peoples Hospital of Neijiang
RECRUITING

Neijiang, 641000, China
Tianjin Medical University Cancer Institute & Hospital
RECRUITING

Tianjin, 300060, China
Townsville Cancer Centre
RECRUITING

Townsville, 4814, Australia
UCLA Hematology-Oncology
RECRUITING

Los Angeles, California, 90095, United States
UCSF Mission Bay Mission Hall
RECRUITING

San Francisco, California, 94115, United States
UNIVERSITATSKLINIKUM GIeBEN UND MARBURG GMBH
RECRUITING

Giessen, 35392, Germany
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, 430022, China
Universitaetsklinikum Frankfurt Goethe-Universitaet
RECRUITING

Frankfurt am Main, 60590, Germany
Universitaetsklinikum Ulm
NOT_YET_RECRUITING

Ulm, 89081, Germany
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, 2650, Belgium
University General Hospital "Attikon"
NOT_YET_RECRUITING

Chaïdári, 124 62, Greece
University General Hospital of Larissa
RECRUITING

Larissa, 41110, Greece
University of Maryland Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami Hospital and Clinics Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198-6811, United States
University of Texas Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Universtitaetsklinikum Essen
RECRUITING

Essen, 45122, Germany
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641-8509, Japan
West China Hospital, Sichuan University
RECRUITING

Chengdu, 610041, China
Wiener Gesundheitsverband Klinik Penzing
RECRUITING

Vienna, 1140, Austria
William Osler Health System - Brampton Civic Hospital
RECRUITING

Brampton, L6R 3J7, Canada
Xiangyang Central Hospital
NOT_YET_RECRUITING

Xiangyang, 441021, China
Yantai Yuhuangding Hospital
RECRUITING

Shandong, 264099, China
Zhejiang Cancer Hospital
NOT_YET_RECRUITING

Hangzhou, 310022, China

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