New hope for tough lung cancer: targeted pill alisertib under study

NCT ID NCT06095505

Recruiting now Disease control Sponsor: Puma Biotechnology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This Phase 2 trial tests the drug alisertib in 120 people with extensive stage small cell lung cancer that has worsened after standard treatments like chemotherapy and immunotherapy. The goal is to see if alisertib can shrink tumors or slow the disease, and to identify which patients might benefit most based on specific biomarkers. Participants take alisertib tablets and are monitored for response and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Alisertib (a targeted cancer drug taken as a tablet)
What this could lead to: If successful, this could provide a new treatment option for people with small cell lung cancer whose disease has progressed after standard therapies.
What could go wrong: This is a Phase 2 trial with only 120 participants, so results are preliminary. The drug may not work for all patients, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER

Contacts and locations

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Clermont Oncology Center
RECRUITING

Clermont, Florida, 64711, United States
Cleveland Clinic
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44195, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Georgetown Lombardi Cancer Center
RECRUITING

Washington D.C., District of Columbia, 20057, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Illinois Cancer Specialists
RECRUITING

Niles, Illinois, 60714, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Marshfield Medical Center
RECRUITING

Marshfield, Wisconsin, 54449, United States
Medical University of South Carolina Hollings Cancer Center
RECRUITING

Charleston, South Carolina, 29425, United States
Minnesota Oncology Hematology
RECRUITING

Burnsville, Minnesota, 55337, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Nebraska Cancer Specialists
RECRUITING

Grand Island, Nebraska, 68803, United States
Northwest Cancer Specialists
RECRUITING

Vancouver, Washington, 98686, United States
Oncology & Hematology Associates of Southwest Virginia
RECRUITING

Blacksburg, Virginia, 24073, United States
Oncology Associates of Oregon
RECRUITING

Eugene, Oregon, 97401, United States
Oncology Hematology Care Clinical Trials
RECRUITING

Cincinnati, Ohio, 45226, United States
Rocky Mountain Cancer Centers
RECRUITING

Lone Tree, Colorado, 80124, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Southern Cancer Center
RECRUITING

Daphne, Alabama, 36526, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center
RECRUITING

Dallas, Texas, 75246, United States
The Oncology Institute of Hope and Innovation
RECRUITING

Long Beach, California, 90805, United States
The Oncology Institute of Hope and Innovation
RECRUITING

Fort Lauderdale, Florida, 33316, United States
UPMC Hillman Cancer Center
WITHDRAWN

Pittsburgh, Pennsylvania, 15232, United States
University Hospital - Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Maryland Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Universtity of Virginia Health System
COMPLETED

Charlottesville, Virginia, 22908, United States
Virginia Cancer Specialists Research Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Zangmeister Cancer Center
RECRUITING

Columbus, Ohio, 43219, United States

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