New drug combo aims to fight aggressive lung cancer

NCT ID NCT07155174

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 18 times

Summary

This study tests a new drug called ABBV-706 combined with the immunotherapy atezolizumab as a first treatment for people with extensive-stage small cell lung cancer, a fast-growing cancer that has spread. About 180 adults will receive either the new combination at one of two doses or standard chemotherapy plus immunotherapy. Researchers will check safety and how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-706 (an investigational drug) combined with atezolizumab (an immunotherapy)
What this could lead to: If successful, this could offer a new first-line treatment option for extensive-stage small cell lung cancer, potentially improving how long patients live without their cancer growing.
What could go wrong: This is an early Phase 2 study with only 180 participants, so results may not apply to everyone. The new combination may cause more side effects than standard care, and it is not yet proven to be better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER

Contacts and locations

Locations

AZ Maria Middelares /ID# 277027
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Ankara Universitesi Tip Fakultesi Cebeci Hastanesi /ID# 277076
RECRUITING

Ankara, 06620, Turkey (Türkiye)
Asan Medical Center /ID# 277603
RECRUITING

Seoul, Seoul Teugbyeolsi, 05505, South Korea
Assuta Ashdod Medical Center /ID# 276661
RECRUITING

Ashdod, Southern District, 7747600, Israel
Baptist Health Lexington /ID# 277729
RECRUITING

Lexington, Kentucky, 40503, United States
Cancer Hospital - Chinese Academy of Medical Sciences /ID# 277167
RECRUITING

Beijing, Beijing Municipality, 100021, China
Chung Shan Medical University Hospital /ID# 277660
RECRUITING

Taichung, 402, Taiwan
Chungbuk National University Hospital /ID# 277429
RECRUITING

Cheongju-si, North Chungcheong, 28644, South Korea
Clinical Hospital Center - Bezanijska Kosa /ID# 277013
RECRUITING

Belgrade, Beograd, 11080, Serbia
Complejo Hospitalario Universitario A Coruna /ID# 276922
RECRUITING

A Coruña, 15006, Spain
Dana-Farber Cancer Institute /ID# 277732
RECRUITING

Boston, Massachusetts, 02215, United States
Evangelische Lungenklinik Berlin /ID# 277094
RECRUITING

Berlin, 13125, Germany
Fondazione Policlinico Universitario Campus Bio-Medico /ID# 277744
RECRUITING

Roma, 00128, Italy
Fort Wayne Medical Oncology And Hematology /ID# 277336
RECRUITING

Fort Wayne, Indiana, 46804, United States
Gazi University Medical Faculty /ID# 276843
RECRUITING

Ankara, 06560, Turkey (Türkiye)
Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi /ID# 276839
RECRUITING

Istanbul, 34722, Turkey (Türkiye)
Grand Hopital de Charleroi - Les Viviers /ID# 276897
RECRUITING

Charleroi, Hainaut, 6280, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 276783
RECRUITING

Liège, Liege, 4000, Belgium
Hadassah Medical Center-Hebrew University /ID# 276662
RECRUITING

Jerusalem, 91120, Israel
Henan Cancer Hospital /ID# 277059
RECRUITING

Zhengzhou, Henan, 450008, China
Hospital Clinic de Barcelona /ID# 276878
RECRUITING

Barcelona, 08036, Spain
Hospital General Universitario Gregorio Maranon /ID# 276877
RECRUITING

Madrid, 28007, Spain
Hospital Regional Universitario de Malaga /ID# 276927
RECRUITING

Málaga, Andalusia, 29010, Spain
Hospital Universitario 12 de Octubre /ID# 277251
RECRUITING

Madrid, 28041, Spain
Institute For Pulmonary Diseases Of Vojvodina /ID# 277003
RECRUITING

Kamenitz, Sremski Okrug, 21208, Serbia
Jessa Ziekenhuis - Campus Virga Jesse /ID# 276781
RECRUITING

Hasselt, Limburg, 3500, Belgium
Kaohsiung Chang Gung Memorial Hospital /ID# 277725
RECRUITING

Kaohsiung City, 833, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 277267
RECRUITING

Kaohsiung City, 807, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 277264
RECRUITING

Taoyuan City, 333, Taiwan
Lungenfachklinik Immenhausen /ID# 278005
RECRUITING

Immenhausen, Hesse, 34376, Germany
Meir Medical Center /ID# 277292
RECRUITING

Kefar Sava, Central District, 4428164, Israel
Missouri Cancer Associates /ID# 278299
RECRUITING

Columbia, Missouri, 65201, United States
Moffitt Cancer Center /ID# 277573
RECRUITING

Tampa, Florida, 33612, United States
Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 277112
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
National Cancer Center /ID# 277434
RECRUITING

Goyang-si, Gyeonggido, 10408, South Korea
National Cancer Center Hospital /ID# 277237
RECRUITING

Chuo-Ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East /ID# 277239
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
Ocala Oncology Center /ID# 278269
RECRUITING

Ocala, Florida, 34474, United States
Rambam Health Care Campus- Haifa /ID# 276663
RECRUITING

Haifa, 3109601, Israel
Samsung Medical Center /ID# 277615
RECRUITING

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Seoul National University Hospital /ID# 277271
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Shanghai East Hospital /ID# 277111
RECRUITING

Shanghai, Shanghai Municipality, 200120, China
Shanghai Pulmonary Hospital /ID# 276960
RECRUITING

Shanghai, Shanghai Municipality, 200433, China
Shizuoka Cancer Center /ID# 277243
RECRUITING

Sunto-gun, Shizuoka, 411-8777, Japan
Taipei Veterans General Hospital /ID# 277263
RECRUITING

Taipei, 112, Taiwan
The Chaim Sheba Medical Center /ID# 276660
RECRUITING

Ramat Gan, Tel Aviv, 5265601, Israel
The First affiliated hospital of Nanchang University /ID# 277247
RECRUITING

Nanchang, Jiangxi, 330006, China
The University of Texas MD Anderson Cancer Center /ID# 277929
RECRUITING

Houston, Texas, 77030, United States
Tokyo Metropolitan Komagome Hospital /ID# 277335
RECRUITING

Bunkyo Ku, Tokyo, 113-8677, Japan
Union Hospital Tongji Medical College /ID# 277912
RECRUITING

Wuhan, Hubei, 430048, China
Universitaetsklinikum Giessen und Marburg GmbH /ID# 277466
RECRUITING

Marburg, Hesse, 35043, Germany
University Clinical Center Kragujevac /ID# 277179
RECRUITING

Kragujevac, Sumadijski Okrug, 34000, Serbia
University Clinical Center Nis /ID# 277180
RECRUITING

Niš, Nisavski Okrug, 18300, Serbia
University Clinical Center Serbia /ID# 277007
RECRUITING

Belgrade, Beograd, 11000, Serbia
University Hospitals Cleveland Medical Center /ID# 277556
RECRUITING

Cleveland, Ohio, 44106, United States
University of Florida College of Medicine /ID# 277496
RECRUITING

Gainesville, Florida, 32610, United States
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie /ID# 276910
RECRUITING

Lublin, Lublin Voivodeship, 20-090, Poland
Virginia Cancer Specialists - Fairfax /ID# 278298
RECRUITING

Fairfax, Virginia, 22031, United States
Wakayama Medical University Hospital /ID# 277260
RECRUITING

Wakayama, Wakayama, 641-8510, Japan
West China Hospital of Sichuan University /ID# 277852
RECRUITING

Chengdu, Sichuan, 610041, China
Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeyla /ID# 276907
RECRUITING

Poznan, Greater Poland Voivodeship, 60-569, Poland
Yale University School of Medicine /ID# 278181
RECRUITING

New Haven, Connecticut, 06510, United States
Yonsei University Health System Severance Hospital /ID# 277597
RECRUITING

Seoul, Seoul Teugbyeolsi, 03722, South Korea

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