New drug combo aims to keep lung cancer in check after initial treatment
NCT ID NCT07545954
First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 5 times
Summary
This early-phase study tests whether adding an experimental drug (DSP-0390) to the immunotherapy atezolizumab can safely help prevent extensive stage small cell lung cancer from growing back after initial chemotherapy and immunotherapy. About 20 adults whose cancer did not worsen after first-line treatment will receive the combination as maintenance therapy. The main goal is to check safety and tolerability, with a secondary look at how well the cancer responds.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DSP-0390 (a cholesterol synthesis inhibitor) and atezolizumab (an immunotherapy drug)
- What this could lead to
- If this combination is safe and shows promise, it could lead to a new maintenance treatment option to help keep extensive stage small cell lung cancer from progressing after initial therapy.
- What could go wrong
- This is a very early, small pilot study with only 20 participants. The combination may cause side effects or not work better than current standard care. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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