New hope for tough lung cancer: targeted drug ZL-1310 enters final testing

NCT ID NCT07218146

Recruiting now Disease control Sponsor: Zai Lab (Shanghai) Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 4 times

Summary

This Phase 3 trial tests ZL-1310, a drug that delivers chemotherapy directly to cancer cells, in people with small cell lung cancer that has returned after initial treatment. About 480 participants will receive either ZL-1310 or one of three standard treatments. The study aims to see if ZL-1310 shrinks tumors more effectively and helps people live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ZL-1310 (a targeted antibody-drug conjugate)
What this could lead to: If successful, ZL-1310 could offer a more effective treatment option for people with relapsed small cell lung cancer, potentially improving response rates and survival.
What could go wrong: This is an early Phase 3 trial, so results are not yet known. The drug may not work better than existing therapies, and side effects could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMALL CELL LUNG CANCER

Contacts and locations

Locations

Zai Lab SIte 01026
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Chengdu, Sichuan, 610041, China
Zai Lab Site 01001
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Guangzhou, Guangdong, 510080, China
Zai Lab Site 01002
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Hefei, Anhui, 230036, China
Zai Lab Site 01004
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Beijing, 100142, China
Zai Lab Site 01005
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Linyi, Shandong, 276000, China
Zai Lab Site 01007
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Jinan, Shandong, 250117, China
Zai Lab Site 01008
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Shijiazhuang, Hebei, China
Zai Lab Site 01009
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Xi'an, Shaanxi, 710061, China
Zai Lab Site 01010
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Zhengzhou, Henan, 450052, China
Zai Lab Site 01011
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Naning, Guangxi, 530021, China
Zai Lab Site 01012
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Nanjing, Jiangsu, China
Zai Lab Site 01014
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Xiamen, Fujian, 361000, China
Zai Lab Site 01015
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Nanchang, Jiangxi, 330029, China
Zai Lab Site 01016
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Taizhou, Zhejiang, 318000, China
Zai Lab Site 01017
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Hangzhou, Zhejiang, 310000, China
Zai Lab Site 01022
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Heilongjiang, Harbin, 000000, China
Zai Lab Site 01034
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Wuhan, Hubei, 430079, China
Zai Lab Site 01043
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Shanghai, Shanghai Municipality, 200433, China
Zai Lab Site 02003
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Bethesda, Maryland, 20817, United States
Zai Lab Site 02006
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Fairfax, Virginia, 22031, United States
Zai Lab Site 02008
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Pittsburgh, Pennsylvania, 15212, United States
Zai Lab Site 02009
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St Louis, Missouri, 63128, United States
Zai Lab Site 02010
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Detroit, Michigan, 48202, United States
Zai Lab Site 02019
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Media, Pennsylvania, 19063, United States
Zai Lab Site 02020
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Rockledge, Florida, 32955, United States
Zai Lab Site 02021
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Peoria, Illinois, 61615, United States
Zai Lab Site 02022
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Silver Spring, Maryland, 20904, United States
Zai Lab Site 02023
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Columbia, Missouri, 65201, United States
Zai Lab Site 02024
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Cleveland, Ohio, 44106, United States
Zai Lab Site 02025
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Austin, Texas, 78745, United States
Zai Lab Site 02025
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Odessa, Texas, 79761, United States
Zai Lab Site 02026
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Sarasota, Florida, 34232, United States
Zai Lab Site 02029
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Pittsburgh, Pennsylvania, 15232, United States
Zai Lab Site 02030
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New Haven, Connecticut, 06519, United States
Zai Lab Site 02031
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Orange City, Florida, 32763, United States
Zai Lab Site 02033
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Sacramento, California, 95817, United States
Zai Lab Site 02035
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Broomall, Pennsylvania, 19008, United States
Zai Lab Site 02036
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Nashville, Tennessee, 37203, United States
Zai Lab Site 02037
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Aurora, Colorado, 80045, United States
Zai Lab Site 02038
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Iowa City, Iowa, 52242, United States
Zai Lab Site 02040
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The Bronx, New York, 10461, United States
Zai Lab Site 02041
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Louisville, Kentucky, 40202, United States
Zai Lab Site 02045
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Clermont, Florida, 34711, United States
Zai Lab Site 02046
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Dallas, Texas, 75390-9020, United States
Zai Lab Site 02047
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Tampa, Florida, 33612, United States
Zai Lab Site 02049
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Peoria, Illinois, 61637, United States
Zai Lab Site 02050
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La Jolla, California, 92093, United States
Zai Lab Site 02051
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West Palm Beach, Florida, 33401, United States
Zai Lab Site 02052
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St. Petersburg, Florida, 33701-4553, United States
Zai Lab Site 08032
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Valencia, Valencia, 46009, Spain
Zai Lab Site 10003
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Shimosuga, Tochigi, 321-0293, Japan
Zai Lab Site 10005
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Koto-Ku, Tokyo, 135-8550, Japan
Zai Lab Site 10006
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Bunkyō-Ku, Tokyo, 113-8677, Japan
Zai Lab Site 10007
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Shinjuku-Ku, Tokyo, 162-8655, Japan
Zai Lab Site 10008
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Bunkyō-Ku, Tokyo, 113-8603, Japan
Zai Lab Site 10009
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Yokohama, Kanagawa, 241-8515, Japan
Zai Lab Site 10010
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Shizuoka, Sunto-gun, 411-8777, Japan
Zai Lab Site 10011
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Hirakata, Osaka, 573-1191, Japan
Zai Lab Site 10012
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Sakai, Osaka, 591-8555, Japan
Zai Lab Site 10013
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Osaka, Osaka, 541-8567, Japan
Zai Lab Site 10014
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Izumi, Osaka, 594-0073, Japan
Zai Lab Site 10015
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Kashihara, Nara, 634-8522, Japan
Zai Lab Site 10016
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Hiroshima, Hiroshima, 734-8551, Japan
Zai Lab Site 10017
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Fukuoka, Fukuoka, 812-8582, Japan
Zai Lab Site 10018
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Fukuoka, Fukuoka, 810-8563, Japan
Zai Lab Site 10019
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Kurume, Fukuoka, 830-0011, Japan
Zai Lab Site 14003
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Istanbul, 34755, Turkey (Türkiye)
Zai Lab Site 14012
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Istanbul, 34295, Turkey (Türkiye)
Zai Lab Site 14013
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Adana, 1060, Turkey (Türkiye)
Zai Lab Site 14014
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Ankara, 6680, Turkey (Türkiye)
Zai Lab Site 20004
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Hilversum, 1261 AN, Netherlands
Zai Lab Site 21001
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Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom
Zai Lab Site 21003
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London, Greater London, W1G 6AD, United Kingdom
Zai Lab Site 21011
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Chelsea, London, SW3 6JJ, United Kingdom
Zai Lab Site 21012
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Sutton, London, SM2 5PT, United Kingdom
Zai Lab Site 22002
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Salzburg, 5020, Austria

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