Pneumonia

This early-stage trial tested a new 23-valent pneumococcal polysaccharide vaccine in 144 healthy people aged 2 and older. Participants received one dose of either the experimental or a control vaccine. The study checked for side effects and measured immune response through blood …

This completed study looked at how effective the Prevnar 13 (PCV13) vaccine is at preventing pneumonia and related infections in adults with HIV. Researchers analyzed health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The g…

This study tested a new vaccine called VAX-24, which targets 24 types of pneumococcal bacteria, in 802 healthy infants. The babies received four doses at 2, 4, 6, and 12-15 months old, alongside routine vaccines. The goal was to check safety and how well the vaccine triggers an i…

Researchers at Xiangya Hospital of Central South University are comparing different sedation regimens used for patients with severe pneumonia in the intensive care unit. The study looks at 260 patients and measures how long they need mechanical ventilation, how well sedation targ…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

Researchers compare two approaches to managing antibiotics in adults hospitalized with community-acquired pneumonia. One approach uses doctors' clinical reassessment to decide whether to continue, stop, or change antibiotics. The other uses blood levels of a marker called procalc…

This trial tests whether a negative MRSA nasal swab can safely guide doctors to stop vancomycin earlier in adults hospitalized with pneumonia. Participants receive standard antibiotics, but vancomycin is either continued or stopped based on the swab result. The goal is to see if …

This study tests whether the steroid hydrocortisone, added to usual care, can help ICU patients with severe hospital-acquired pneumonia. Researchers will compare hydrocortisone against a placebo in 180 adults. The goal is to see if the drug reduces early death or worsening of bre…

This trial tests whether an automated oxygen delivery system, called FreeO2, can help patients with pneumonia recover faster and leave the hospital sooner. The device automatically adjusts oxygen flow based on continuous monitoring of blood oxygen levels, aiming to keep patients …

This trial examines whether using a quick nasal swab to check for MRSA bacteria can help doctors decide how long to treat pneumonia patients with the antibiotic vancomycin. The study compares the duration of therapy and costs before and after implementing this screening test. Par…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tests two approaches to reduce the overuse of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Researchers will compare rapid diagnostic testing and pharmacist-led de-escalation, alone or together, against usual care. The goal is to …

This study tested whether a combination of small amounts of tube feeding plus extra nutrition through an IV could reduce pneumonia in people with severe stroke. The trial enrolled 546 adults who had trouble swallowing. Researchers compared this approach to standard full tube feed…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This early-stage trial tested a single inhaled dose of FLAMOD, a protein that mimics a bacterial signal to activate the immune system, in 46 healthy adults. The goal was to check safety and see if it triggers a local immune response in the lungs. If it works, this approach might …

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested a drug called Auxora in 314 people with severe COVID-19 pneumonia. The goal was to see if it could help patients recover faster and reduce the need for breathing machines. Participants received either Auxora or a placebo, along with standard treatments. Results …

This study tested an experimental drug called AON-D21 in 150 ICU patients with severe community-acquired pneumonia. The goal was to see if adding AON-D21 to standard care is safe and helps patients recover faster compared to a placebo. The trial focused on how quickly patients co…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This completed trial tested whether a rapid MRSA nasal swab test could help doctors safely stop an antibiotic called vancomycin in adults with pneumonia in the intensive care unit. 277 participants were randomly assigned to have their swab results reported to their doctor or to r…

This study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…

This study tested a personalized approach for people with severe COPD. Doctors used a simple blood test (eosinophil count) to decide whether to reduce inhaled steroids, and some patients also received the antibiotic azithromycin. The goal was to see if this strategy could reduce …

This study looked at whether giving children a longer course of antibiotics (amoxicillin-clavulanic acid) after hospitalization for pneumonia leads to better recovery compared to a shorter course. It involved 314 children aged 3 months to 5 years in Australia. The goal was to see…

This study tested an inhaled mixture of bacteria-killing viruses (phages) in 48 adults with bronchiectasis and chronic Pseudomonas lung infections. Participants received either the phage therapy or a placebo by inhalation. The goal was to see if the phages could safely reduce the…

This study tested whether low-dose hydrocortisone, a common steroid, can help people with severe community-acquired pneumonia survive. Over 950 critically ill adults in intensive care received either the steroid or a placebo, alongside standard antibiotics and support. The goal w…

This study tested whether using very small breaths (ultraprotective ventilation) on a breathing machine, without a heart-lung bypass machine, could improve survival and reduce time on the ventilator for COVID-19 patients with severe lung injury. About 220 adults with confirmed CO…

This study tested whether using lung ultrasound to guide how nurses position ventilated newborns can prevent pneumonia better than standard repositioning every two hours. Researchers enrolled 80 full-term infants on breathing machines. The goal was to see if personalized position…

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe. 185 patients were randomly assigned to receive one of the drugs or standa…

This study looked at how well the antibiotic Klacid SR works for adults with respiratory infections like bronchitis and mild pneumonia, especially in those who had taken it before. Over 3,000 participants were treated in regular doctor visits, and doctors checked if symptoms impr…

This study tested whether a salmon oil supplement called CARDIO® could help control asthma in adults. 70 participants took either the supplement or a placebo alongside their usual asthma medications. The goal was to see if the supplement reduced asthma attacks and improved breath…

This study tested whether giving children with pneumonia a daily oral rehydration solution (ORS) for three days could shorten their hospital stay. Researchers compared 140 children aged 1 month to 5 years who received ORS to those who did not. The goal was to see if this simple, …

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested whether adding a procedure called fiberoptic bronchoscopy to standard care helps adults with severe ventilator-associated pneumonia. One hundred patients were split into two groups: one got usual treatment (antibiotics, suctioning), the other got the same plus d…

Researchers in Senegal are testing a new way to care for children under 15 who come to primary health clinics with fever or diarrhea. The strategy combines rapid tests for malaria, dengue, and strep A with a digital tool that suggests treatment based on symptoms and test results.…

This study tested a rapid diagnostic test (BioFire Pneumonia Panel) in 40 ICU patients on ventilators with suspected pneumonia. Half got the rapid test, half got standard care. The goal was to see if the test helps doctors give the right antibiotics sooner. Results could lead to …

This study tested whether using a low-dose CT scan or lung ultrasound is more accurate than the usual chest X-ray for diagnosing pneumonia in people over 65. About 473 older adults with suspected pneumonia in the emergency room took part. The goal was to see if better imaging cou…

This study looked at whether lung ultrasound (LUS) can accurately diagnose pneumonia in children in low-resource settings, where chest X-rays are often unavailable. Researchers compared LUS results to a 'gold standard' diagnosis based on clinical exams, imaging, and lab tests. Th…

This study tested a machine learning tool that uses routine medical data to predict pneumonia risk within the first week after brain tumor surgery. Researchers included over 1,800 adults having their first planned brain tumor removal. The goal was to see if the AI could help doct…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This study looked at a blood test called Beta-D-glucan (BDG) to see how well it detects invasive fungal infections in people with weak immune systems. Researchers tested 280 patients and checked if two positive results within 15 days confirmed an infection. The goal is to help do…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This study looked at 339 emergency room patients with suspected pneumonia to see if a chest CT scan could improve diagnosis. The goal was to find out if the CT scan changed the doctor's initial diagnosis, and if it led to changes in antibiotic treatment or hospital admission deci…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This completed study tested whether adding toothbrushing and oral gel to standard chlorhexidine mouthwash could prevent ventilator-associated pneumonia (VAP) in 100 ICU patients. The intervention group received comprehensive oral care, while the control group got mouthwash alone.…

This study tested a new vaccine called AFX3772 in healthy infants about 2 months old. The goal was to see if it is safe and triggers a strong immune response against pneumococcal bacteria, which can cause pneumonia and other serious infections. Researchers compared AFX3772 with e…

This study tested whether a teacher-led hygiene campaign in primary schools in Lagos, Nigeria, could improve handwashing and prevent diarrhea, undernutrition, and pneumonia in children. Over 3,500 children from schools with clean water and toilets took part. Researchers measured …

This study combines data from two large trials in Denmark and Spain involving over 466,000 older adults. It compares the high-dose flu vaccine (Efluelda/Fluzone High-Dose) to the standard-dose flu shot to see which better prevents severe outcomes like hospitalization for flu or p…

This study looked at whether giving antibiotics early to trauma patients on breathing machines can prevent ventilator-associated pneumonia. Researchers analyzed data from 2,143 adults admitted to intensive care after severe trauma. The goal was to see if early antibiotics reduce …

This large study tested whether a high-dose flu vaccine works better than the standard-dose shot in adults 65 and older. Over 332,000 participants were randomly assigned to receive either the high-dose or standard-dose vaccine. Researchers tracked hospitalizations for flu, pneumo…

This study tests a personalized approach to giving the steroid dexamethasone to hospitalized adults with pneumonia. Instead of a standard dose, the amount is adjusted daily based on a blood marker called C-reactive protein (CRP). The goal is to reduce steroid side effects while s…

This study looked at 80 children aged 1 month to 5 years with severe breathing problems from pneumonia or bronchiolitis. It compared two non-invasive breathing support methods: High Velocity Nasal Insufflation (HVNI) and Nasal Continuous Positive Airway Pressure (CPAP). The goal …

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This completed study looked at how genetic differences might change the way immune cells in the lungs respond to environmental triggers like dust and germs. Researchers collected blood and lung samples from 20 healthy adults to compare cell function between people with different …

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This study investigates how viral infections influence the community of bacteria in the airways of young children with cystic fibrosis. Researchers will collect throat swabs from children under 5 years old over one year, tracking their microbiome, inflammation, and clinical sympt…

This study observes people in Belgium with non-invasive pneumococcal infections like pneumonia, ear infections, and sinusitis. Researchers will collect bacterial samples to see which strains are circulating and how they compare to invasive infections. The goal is to understand ho…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study looks back at medical records of adults who were sent home from the emergency department to receive hospital-level care for common infections like pneumonia, urinary tract infections, or skin infections. The goal is to understand why some of these patients end up needi…

This study looks at whether a procedure called flexible bronchoscopy can help doctors find the exact germ causing pneumonia in children who are not getting better with standard antibiotics. The study will include 58 children in the intensive care unit at a hospital in Cairo. If i…

This completed study looked at 104 adults in the ICU with severe pneumonia caused by three common bacteria. Researchers checked whether the bacteria were sensitive to amoxicillin/clavulanic acid (AMC) or to third-generation cephalosporins (3GC), which are standard treatments. The…

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This completed study from France looked at health records of 2 million adults to see if having pneumonia increases the chance of later heart problems like heart attacks, strokes, or heart failure. Researchers compared people who had pneumonia with similar people who did not. The …

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study tested whether using a device that sends mild electrical pulses to the leg muscles (NMES) could help older adults recover strength and mobility after being hospitalized for a COPD flare-up or pneumonia. Seven participants used the device in the hospital and at home for…

This completed study tested whether an AI system could improve how ventilators are set for children (ages 1 month to 18 years) in the pediatric ICU with breathing problems like pneumonia or respiratory failure. Researchers compared AI-generated recommendations to the actual adjus…

This study tested a program where rural hospitals connect with an infectious disease expert through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant infections. Eight VA medical centers participated, and the approach h…

This study tested whether a tool called the ARISCAT score can predict lung complications (like pneumonia or collapsed lung) after major abdominal cancer surgery. Researchers followed 410 adults who had surgery under general anesthesia. The goal was to see if the score could help …

This study tested a new way to decide if patients with lower respiratory tract infections need antibiotics. Instead of relying on standard methods, doctors used a step-by-step approach: a clinical score, a lung ultrasound, and a blood test for procalcitonin. The goal was to reduc…

This study looked at whether a set of care guidelines (called a pathway) could help doctors and nurses in community hospitals use the best treatments for children hospitalized with asthma, pneumonia, or bronchiolitis. Over 11,000 children took part across many hospitals. The goal…

This study tested whether electronic alerts and structured messages from an antibiotic stewardship team could reduce antibiotic use in hospitalized patients with suspected pneumonia. 107 adults were enrolled, and those with test results suggesting viral infection were randomly as…

This study aimed to find biomarkers in patients with pneumonia. Researchers enrolled 272 participants and tracked outcomes like death in the hospital and whether the pneumonia got worse. The goal was to better understand the disease, not to test a new treatment.

This study observed over 1,800 children hospitalized for serious breathing problems like bronchiolitis, pneumonia, or asthma. It aimed to track how many children were hospitalized for bronchiolitis after a new immunization became available. The study did not test any new treatmen…

This study tested three different oximeters (Masimo, Nellcor, Nonin) at various oxygen targets in 40 patients with and without COPD. The goal was to see how the choice of oximeter and target affects the amount of oxygen needed. Results could help guide safer oxygen therapy.

This study created and tested a risk score called RESPIRE to predict whether a patient's pneumonia is caused by multidrug-resistant bacteria. Researchers looked at data from 300 adults with community-acquired pneumonia in the emergency department. The goal is to help doctors quic…

This completed study analyzed over 230,000 adults in France who had lower respiratory tract infections like pneumonia, bronchitis, or flu. Researchers used anonymous electronic health records from 2015 to 2024 to describe patient characteristics, how often antibiotics were prescr…

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study looked at how fat (lipid) metabolism is linked to severe pneumonia caused by COVID-19 versus other germs. Researchers measured cholesterol and other fat-related substances in 62 adults with severe pneumonia. The goal was to understand these differences, not to test a t…

This study looked at 76 ICU patients with severe pneumonia who were placed on a lung machine (ECMO) and given minimal ventilator support. Researchers wanted to see if this approach changed how well the kidneys worked. They reviewed medical records from 2019 to 2023, comparing uri…

This completed study looked at 179 ICU patients with pneumonia to figure out the best doses of common antibiotics. Researchers took blood and lung fluid samples to measure how the drugs move through the body. The goal was to create personalized dosing plans that ensure enough ant…

This study looked at 150 adults who had severe COVID-19 pneumonia to find out how many develop long-term lung issues. Researchers used CT scans to check for lung scarring and other damage months after infection. The goal is to better understand the lasting effects of severe COVID…

This study looked at 688 adults hospitalized with pneumonia in 11 hospitals in Colombia to find out how many cases were caused by pneumococcal bacteria. Researchers also identified which bacterial strains were most common and whether current vaccines cover them. The goal is to he…

This study reviewed the medical records of 239 patients aged 65 and older who had major abdominal surgery. The goal was to find out what factors increase the risk of lung complications like pneumonia or respiratory failure after surgery. By understanding these risks, doctors may …

This study tested whether a special belt that creates images of the lungs (Electrical Impedance Tomography) can safely help doctors choose the best pressure settings on a breathing machine for infants under 3 years old. The study included 14 children with various serious conditio…

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This completed study looked at how the antibiotics amoxicillin and clavulanic acid get into the infected fluid around the lungs in people with pleural infections. Eleven adults with complicated infections had chest tubes placed and received the antibiotics. Researchers measured a…

This study looked at how the antibiotic ceftobiprole moves through the blood and lungs of 12 adults with severe pneumonia who were on breathing machines. Researchers gave a high dose continuously through a vein and took blood and lung fluid samples to measure drug levels. The goa…

This study tested ways to reduce unnecessary antibiotic use in hospitalized patients being treated for pneumonia, but who had normal breathing and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to s…

This study looked at 1000 patients who needed extra tools to place a breathing tube during surgery. Researchers wanted to see if these patients had a higher chance of lung problems like pneumonia afterward. The goal was to better understand risks and improve patient safety.

This study tested whether giving doctors automated reports on their antibiotic prescribing habits could improve how often they follow official guidelines. Researchers looked at over 26,000 patients with pneumonia, ear infections, or sore throat. They compared antibiotic use befor…

This study tested a new AI system (Janus Pro 1B-CXR) designed to help radiologists interpret chest X-rays. The AI was developed using public data and evaluated in 296 patients with suspected chest diseases. Researchers compared report quality, reading time, and agreement between …

This completed study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease worse. Researchers compared survival rates between patients infected with PVL-producing bacteria and those without. They also collected blood samples to explore …

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…