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Which sedation approach helps pneumonia patients breathe on their own sooner?

NCT ID NCT06514781

NEW Disease control Sponsor: Xiangya Hospital of Central South University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers at Xiangya Hospital of Central South University are comparing different sedation regimens used for patients with severe pneumonia in the intensive care unit. The study looks at 260 patients and measures how long they need mechanical ventilation, how well sedation targets are met, and how their circulation and overall outcomes change. The goal is to understand which sedation approach works best in real-world ICU care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
different sedation protocols used in intensive care
What this could lead to
If one sedation approach helps patients come off ventilators sooner, it could shape how intensive care units manage severe pneumonia in the future.
What could go wrong
This study observes patients in one hospital's real-world setting rather than randomly assigning treatments, so differences between sedation regimens may reflect patient characteristics rather than the drugs themselves.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

260 people

The number who actually took part.

Started

Feb 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

From February 1, 2023, to December 31, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: (1)From February 1, 2023, to December 31, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria: 1. Major criteria: ①Infectious shock requiring vasopressor therapy despite adequate fluid resuscitation; ②Respiratory failure requiring tracheal intubation or mechanical ventilation. 2. Minor criteria: * Respiratory rate ≥ 30 breaths/min; * Oxygenation index (PaO2/FiO2) ≤ 250; ③Involvement of multiple lobes; * Altered mental status and/or disorientation; ⑤Blood urea nitrogen ≥ 20 mg/dl (7.14 mmol/L); ⑥Systolic blood pressure \< 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving invasive mechanical ventilation who require continuous sedation treatment. (3)Age ≥ 18 years. Exclusion Criteria: 1. Allergic to routine sedative or analgesic medications. 2. Patients who have not undergone sedation-agitation assessment. 3. Patients transferred to another hospital during treatment. 4. Patients who withdrew from active treatment or were discharged from the ICU within 72 hours after initiation of sedation.

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Conditions

The condition(s) this trial relates to.

pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Severe pneumonia

Contacts and locations

Locations

  • Xiangya Hospital Central South University

    Changsha, Hunan, 410008, China

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