Human papilloma virus infection

This study looks at whether a 2-dose regimen of the Gardasil 9 HPV vaccine, given 12 months apart, triggers a strong immune response in children aged 4 to 8. The vaccine is currently approved for ages 9 and up, but this research explores if starting earlier could provide protecti…

This study tests Cervavac, an HPV vaccine, in women aged 15-25 who are living with HIV. HPV infection can lead to cervical cancer, and women with HIV are at higher risk. The trial compares two-dose and three-dose schedules of Cervavac against a standard vaccine to see how well th…

This study looks at whether giving money to clinics can encourage doctors to talk about and offer the HPV vaccine more often. Some clinics get training on how to talk about the vaccine, while others get the same training plus a financial reward and monthly progress reports. The g…

This study tests whether the Gardasil 9 vaccine can help stem cell transplant patients build immunity against HPV. About 48 adults who had a stem cell transplant for blood cancer will receive the vaccine. Researchers will measure antibody levels to see if the vaccine works in the…

This study looks at whether giving a smaller (one-fifth) dose of the HPV vaccine, either into the skin or muscle, can still trigger a strong immune response in adults aged 27 to 45. About 92 men and women in Seattle will have their antibody levels checked over a year. The goal is…

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. Researchers will measure antibody levels in 30 transplant recipients over 24 months and compare them to published data from healthy individuals. The goal is to see if the …

This study is testing whether a 2-dose schedule of the HPV vaccine (Gardasil 9) is as effective as the standard 3-dose schedule in women aged 16 to 45. Researchers will measure antibody levels in 352 women to compare immune responses. If the 2-dose regimen works well, it could si…

This study tests whether the HPV vaccine Gardasil 9 can trigger an immune response in people with idiopathic CD4 T cell lymphocytopenia (ICL), a rare condition that weakens the immune system. About 54 adults with ICL and some healthy volunteers will receive three doses of the vac…

This study is testing whether giving the HPV vaccine (Gardasil 9) on a different schedule still works well in healthy 9-11 year olds. The standard schedule uses two or three doses, but this study gives a first dose and then a booster later. Researchers will measure antibody level…

This early-stage trial tests a new vaccine called V540D, designed to protect against more types of human papillomavirus (HPV) than the current Gardasil 9 vaccine. The study involves 72 healthy adults and will compare the safety and immune response of V540D to Gardasil 9. The main…

This study tests an experimental HPV vaccine in 1,800 females aged 9 to 35. The goal is to see if giving two doses to girls aged 9-14 works as well as three doses in older girls and women. Participants receive the vaccine in their upper arm and have several visits to check their …

This Phase 3 trial tests a 9-valent HPV vaccine in over 9,000 healthy women aged 18-45. The vaccine targets nine HPV types linked to cervical cancer and genital warts. Researchers compare it to an existing 2-valent vaccine to see if it provides broader protection. The goal is to …

This study in Tanzania tests whether one dose of the HPV vaccine works as well as the standard two or three doses in girls aged 9-14. Cervical cancer is a major killer in East Africa, and reducing the number of shots could cut costs and make vaccination more accessible. The trial…

This study looks at whether giving lower doses of radiation to a smaller area after robotic surgery can still keep HPV-positive throat cancer from coming back. About 150 adults with early-stage throat cancer will receive this gentler radiation plan. The goal is to see if two year…

This study tests a combination of three drugs—bintrafusp alfa, PDS01ADC, and entinostat—in adults with advanced HPV-related cancers (like cervical, anal, or throat cancer) or certain colon cancers that haven't responded to standard treatment. The goal is to find a safe dose and s…

This phase II trial tests whether bevacizumab, a drug that blocks blood vessel growth, can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a rare condition causing wart-like growths in the airways. Participants receive 11 doses of t…

This phase 2 trial tests whether giving the HPV vaccine (Gardasil 9) to adults before a kidney transplant helps their immune system fight HPV after transplant, when they must take drugs that weaken immunity. About 51 participants will receive the vaccine before surgery, and resea…

This early-phase trial tests a biological product mix designed to train the immune system to recognize and clear multiple strains of HPV. The study involves 20 participants with cervical HPV infection who do not have symptoms or signs of cancer. The treatment is given through the…

This study was designed for people with HPV-positive oropharyngeal cancer who still had signs of the virus in their blood after completing standard treatment. Researchers planned to give an immunotherapy drug called BALSTILIMAB to see if it could clear the virus and improve long-…

This study tests two experimental vaccines (HB-201 and HB-202) given with standard chemotherapy drugs (carboplatin and paclitaxel) to people with HPV16-positive oropharyngeal cancer. The goal is to see if this combination can shrink tumors enough to allow less intensive follow-up…

This study looks at people with HPV-positive throat cancer that has spread but can still be removed with surgery. After surgery, some patients get the usual high-dose radiation plus chemo, while others get a lower dose. The goal is to see if the lower dose works just as well and …

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This early-phase trial tests an HPV vaccine series in healthy relatives of patients with advanced HPV-related cancer. The goal is to generate HPV-specific white blood cells that can be collected and used in a bone marrow transplant or donor lymphocyte infusion for the patient. Th…

This study tests an experimental vaginal insert (ABI-2280) to see if it can safely clear persistent high-risk human papillomavirus (HPV) infection in women aged 25 to 55. Participants must have had HPV for at least a year with no serious cervical changes. The study compares diffe…

This early-stage study tests a new treatment called T-Plex for people with advanced solid tumors (like head and neck, cervical, or melanoma) that haven't responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and…

This study tests whether a natural vaginal gel called CH2 can help women with mild cervical changes (CIN1) and high-risk HPV clear the infection and heal faster. Fifty women will use either the gel or a placebo twice a week for 24 weeks. Researchers will track Pap smear results a…

This study compares different HPV tests to find the best way to screen for cervical cancer in women living with HIV in Latin America. Over 1,000 participants will provide cervical, vaginal, and urine samples, plus undergo colposcopy and biopsies. The goal is to identify which tes…

This study compares self-collected vaginal samples to clinician-collected samples for HPV testing in 500 people referred for colposcopy. The goal is to see if self-collection is accurate enough to improve cervical cancer screening rates. Participants will provide both types of sa…

This study tests whether women can collect their own vaginal samples for HPV testing as accurately as a doctor's sample. It involves 750 women referred for colposcopy or cervical procedures. The goal is to see if self-collection is a reliable alternative to traditional pelvic exa…

This study is testing a blood test that looks for HPV DNA in the blood of people treated for HPV-positive oropharyngeal cancer. The goal is to see if the test can find cancer recurrence earlier than standard follow-up methods. About 150 participants are being followed after treat…

This study compares HPV testing on self-collected vaginal samples versus samples collected by a doctor during a pelvic exam. About 500 people referred for colposcopy or cervical procedures will provide both types of samples. The goal is to see if self-collection is accurate enoug…

This study is looking for better ways to find HPV-related throat and anal cancers early in men. Researchers are testing whether a blood test or a simple mouth rinse can spot signs of the virus that might lead to cancer. They plan to follow 1,500 men over time to see if these test…

This study is checking if a new, low-cost HPV test called ScreenFire works as well as the standard test for finding cervical cancer risk. About 9,100 women aged 30-59 will use a self-collection method. The goal is to see if the test is accurate, reduces follow-up visits, and is c…

This study looks at whether women with immune-mediated inflammatory diseases (like lupus or Sjögren's syndrome) can use a vaginal self-sampling kit to check for high-risk HPV, the virus that can cause cervical cancer. Researchers will track 300 women aged 30-65 to see how many ha…

This study looks at whether offering HPV self-sampling kits by mail, pharmacy, or clinic can make cervical cancer screening easier. One thousand women aged 25-65 in Quebec will try different ways to get and return the kit. The goal is to see which method works best and if women f…

This study is testing whether women in Indonesia can successfully collect their own samples for HPV testing, which could make cervical cancer screening more accessible. Researchers will enroll 8,000 women aged 30-69 who haven't been screened recently. The goal is to see if self-c…

This study tests whether a campaign designed and run by high school students can increase HPV vaccination in Chambers County, Alabama, which has the state's highest cervical cancer rate. Twenty-nine students will create and spread messages through multiple channels to encourage t…

This study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…

This study looks at whether giving girls aged 9-14 two different HPV vaccines in a sequence is safe and boosts immunity. The researchers will measure antibody levels and side effects in 400 participants. The goal is to see if this approach can improve protection against HPV, whic…

This study tests whether offering women a simple self-collection kit for HPV testing at Express Care clinics (which have evening and weekend hours) increases cervical cancer screening rates. About 500 women aged 30–63 who are overdue for screening will either receive usual care o…

This study tests whether a clinic-based outreach program can help more rural parents get their children (ages 9-17) the HPV vaccine. Researchers are working with 1,455 families at community clinics in the Mountain West. The goal is to see if simple communication and engagement st…

This phase 3 study tests a 9-valent HPV vaccine (V503) in 6,000 Chinese women aged 20-45 to see if it prevents persistent infection and cervical disease from five additional HPV types compared to the current 4-valent vaccine. Participants receive either the new vaccine or Gardasi…

This study tests a program to help HIV-positive adults get the HPV vaccine, which can prevent HPV-related cancers. The program gives clinics and staff tools to encourage vaccination. Researchers will track how many people start and finish the vaccine series over two years.

This study tests if giving the HPV vaccine to children at age 9-10, instead of the usual 11-12, leads to more kids getting fully vaccinated before they are exposed to the virus. The goal is to prevent HPV-related cancers later in life. About 3,100 children in Colorado and Califor…

This trial tests whether training primary care clinics to better use HPV vaccine standing orders can increase vaccination rates in children ages 9-12. Some clinics receive communication training alone, while others also get help optimizing their standing orders. The study uses va…

This study tests whether a short educational session plus weekly text reminders can increase HPV vaccination rates among children of Mexican-American parents. About 672 parents will be randomly assigned to receive either education alone or education plus text reminders. The goal …

This study looks at ways to help more teens in rural areas get the HPV vaccine, which can prevent certain cancers. Researchers are working with 203 primary care practices to test a program called PC TEACH. The goal is to make it easier for families to get the vaccine on time.

This study tested whether a social marketing campaign—with or without text message reminders—could increase the number of Mexican American children ages 9 to 17 who complete the full 3-dose HPV vaccine series. About 181 parents in the New York City area took part. The goal was to…

This study tests a community-driven campaign to increase HPV prevention among mother-daughter pairs in Nigeria. About 1,838 participants will take part in events and surveys. The goal is to get more girls vaccinated against HPV and more mothers to self-test for the virus, which c…

This study looks at how to increase HPV vaccination rates among young adults aged 18-26 in Texas. Researchers will test different ways to encourage college students who haven't had the vaccine to start and complete the series. The goal is to prevent HPV infections and related can…

This study tests whether a single dose of the HPV vaccine (Gardasil 9) can prevent persistent HPV infection in women living with HIV who have already been vaccinated. About 778 women will receive either the HPV vaccine or a meningitis vaccine (placebo) and be monitored for safety…

This study tested whether an educational program for parents and healthcare providers could increase HPV vaccination rates among girls aged 9 to 17 in Ohio Appalachia. Over 600 parents and providers took part. The goal was to see if teaching about the vaccine leads to more girls …

This study is testing whether a single dose of the HPV vaccine (Gardasil 9) can protect young women from HPV infection. Over 150,000 women in Sweden are participating, receiving one vaccine dose along with routine screening. The goal is to see if one dose is effective enough to h…

This study tests ways to increase HPV vaccination among 11-17 year olds at 8 community health centers in Florida. It provides training for doctors and nurses on how to recommend the vaccine, and gives parents easy-to-understand information before visits. The goal is to see if the…

This study tests whether sending vaccine reminders by text, email, or mail can increase HPV vaccination rates among 12-year-olds in rural areas, where uptake is lower. Over 5,400 teens in a regional healthcare system are enrolled. Parents receive reminders every other month until…

This study tests a school-based communication strategy to help more children aged 9-12 in South Africa get the HPV vaccine, which prevents cancers caused by HPV. The program involves health materials and vaccine provision in schools. Researchers will measure how many children sta…

This study tests whether mailing a self-sampling HPV test kit to Asian and underserved women can increase cervical cancer screening rates. Participants receive a kit to collect a sample at home and send it back for testing, along with phone support. The goal is to make screening …

This study in Tanzania tests whether giving boys a single dose of the HPV vaccine (Gardasil) can lower HPV infections in the community. Over 10,000 participants in 26 communities will be split: some communities vaccinate only girls (as usual), while others also vaccinate boys age…

This large study of nearly 28,000 girls aged 12-16 tests whether a single dose of HPV vaccine works as well as the standard two doses to prevent persistent infection with the virus types that cause most cervical cancers. If one dose is enough, it could lower costs and simplify va…

This study tests ORCHID, an online skills-building program designed to improve mental health and reduce the risk of dropping out of care for aging women with HIV who also have HPV. The program includes 8 online sessions and optional meetings with a navigator. The study aims to se…

This study compares two treatments for early-stage throat cancer: robotic surgery (TORS) or radiation therapy (IMRT). It looks at which one leads to better swallowing function and overall quality of life. About 138 adults with HPV-related throat cancer are taking part. The goal i…

This study follows over 8,600 women in Costa Rica who received the HPV vaccine (types 16 and 18) years ago, plus unvaccinated controls, to see how well the vaccine protects over time. Researchers are checking for cervical lesions, immune markers, and any increase in infections fr…

This study tests whether a virtual training and peer-mentoring program called Project ECHO can help healthcare providers in Ethiopia improve cervical cancer screening and treatment for women living with HIV. The program focuses on using HPV self-sampling, a simpler screening meth…

This observational study follows 168 women living with HIV in Zimbabwe who have been treated for cervical pre-cancer. Researchers want to learn how often the disease comes back and whether HPV or DNA tests can predict recurrence. Participants will be monitored every six months fo…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This study looks at how well the HPV vaccine works in women living with HIV and whether self-collected HPV tests can improve cervical cancer screening. About 650 women will use a self-swab kit at home or in the clinic. Those with positive results will get follow-up exams. The goa…

This study is checking how long the HPV vaccine protects women who received one, two, or three doses. Researchers are following about 946 women from an earlier trial in Costa Rica for up to 20 years after their shots. By testing blood samples, they hope to learn if one dose might…

This study is testing whether a smaller, one-fifth dose of the HPV vaccine, given into the skin instead of the muscle, can still trigger a good immune response in adults aged 27 to 45. Researchers are comparing two types of HPV vaccines in 40 volunteers in Seattle. The goal is to…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study explores whether transgender individuals can collect their own samples for HPV testing at home or in a clinic. Researchers want to learn how common high-risk HPV is in this group and whether self-sampling is acceptable and effective. About 100 transgender men and women…

This study looks at whether offering cervical cancer screening in the emergency department helps more people get tested. About 200 women and transgender/non-binary individuals with a cervix, aged 25-65, will be offered a self-sampling kit or clinic referral. Researchers will call…

This study looks at how the HPV vaccine (Gardasil-9) triggers a strong and lasting immune response. Researchers will track 17 healthy adults aged 18-45 who receive three doses of the vaccine. By analyzing blood, saliva, lymph nodes, and bone marrow over several years, they aim to…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study is screening 1,500 adults for oral HPV infection and antibodies to build a group at higher risk for HPV-related throat cancer. Researchers will follow them over time to see which infections persist and what factors (like mouth bacteria or immune response) increase canc…