Could mixing HPV vaccines offer better protection?

NCT ID NCT07281677

Ongoing Prevention Sponsor: Zhejiang Provincial Center for Disease Control and Prevention Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether giving girls aged 9-14 two different HPV vaccines in a sequence is safe and boosts immunity. The researchers will measure antibody levels and side effects in 400 participants. The goal is to see if this approach can improve protection against HPV, which causes cervical cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HPV vaccines (bivalent and 9-valent)
What this could lead to: If successful, this could show that using different HPV vaccines in sequence is a safe and effective way to protect against more types of HPV, potentially improving cervical cancer prevention.
What could go wrong: This is a Phase 4 study with 400 girls, so results may not apply to all populations. The main focus is on immune response and safety, not long-term cancer prevention, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

human papilloma virus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HPV INFECTION

Contacts and locations

Locations

Jinyun center for Disease Control and Prevention

Lishui, Zhejiang, 321400, China

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