Human papilloma virus infection

This study looks at children and teens with HIV to find the best number of HPV vaccine doses. Researchers are comparing one, two, or three doses to see if fewer shots can still provide strong protection against HPV. The goal is to simplify vaccination and improve health outcomes …

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested different ways to help teenagers complete the HPV vaccine series at community health centers serving low-income families. Researchers compared parent reminders (by mail and text), clinic system changes, and a combination of both against usual care. Over 17,000 t…

This study looked at whether 2 doses of the HPV vaccine (Gardasil 9) protect as well as the standard 3 doses in people aged 15 to 26. Researchers measured antibody levels against nine HPV types. The goal is to see if a simpler schedule could work, making vaccination easier and ch…

This completed Phase 3 study tested a 9-valent HPV vaccine in nearly 2,000 healthy Chinese females aged 9 to 45. The goal was to see if the vaccine triggers a strong immune response and is safe. Participants received three doses, and researchers measured antibody levels over five…

This study looked at whether giving the HPV vaccine and the Moderna COVID-19 vaccine at the same time is safe and works well for children aged 9 to 11. About 165 boys and girls took part. The researchers compared kids who got both vaccines on the same day to those who got them on…

This study tested whether an education program helps low-income, uninsured adults aged 18-45 accept and complete a free HPV vaccine series. The goal is to prevent HPV-related cancers. About 100 participants took part, and researchers tracked how many started and finished the vacc…

This study looked at whether combining school education, doctor training, and offering the vaccine at school can increase HPV vaccination among French adolescents aged 11 to 14. Over 30,000 teens from 90 towns took part. The goal was to see if these efforts make more teens get th…

This study tested whether a vaginal insert containing artesunate, a malaria drug, could help clear HPV after standard cervical precancer treatment in women living with HIV. 120 women in Kenya used the insert or a placebo for 5 nights on and off over 6 weeks. The goal was to see i…

This trial tested a new therapy for cancers caused by HPV-16, such as cervical, anal, and throat cancers. Researchers took patients' white blood cells, genetically engineered them to recognize a protein called E7 found in HPV cancer cells, and infused them back. Patients also rec…

This study looked at whether using an anti-cancer cream (5-fluorouracil) in the vagina after surgery is an acceptable and feasible way to treat cervical precancer in 180 South African women living with HIV. The goal was to see if women would stick with the treatment and find it a…

This study tested a treatment for people with HPV-related throat cancer. It combined a higher dose of radiation with the chemotherapy drug docetaxel. The goal was to see if this approach could better control the tumor and improve survival. The study involved 81 participants and w…

This study tested whether a heated probe applied to the cervix (thermal ablation) can help clear persistent HPV infection in women aged 40 and older. A total of 131 women with long-lasting HPV were randomly assigned to receive the treatment or no treatment, and their HPV status w…

This study looked at whether the HPV vaccine can help prevent high-grade cervical lesions (precancerous growths) in women living with HIV who were already being treated for HPV. About 536 women took part, receiving either the HPV vaccine or a placebo. The goal was to see if the v…

This study looked at whether a supplement made from shiitake mushrooms (AHCC) can help women clear a long-lasting high-risk HPV infection. Researchers reviewed medical records of 289 women who either took the supplement, got the HPV vaccine, or did both. The goal was to see if th…

This study tested whether giving the HPV vaccine (Gardasil) to women with large or extensive genital warts before surgery could prevent the warts from coming back. The trial included 52 women, some with HIV and some without. Researchers measured changes in wart size and antibody …

This large phase 3 trial studied nearly 1,000 people with HPV-related oropharyngeal cancer to see if replacing chemotherapy with a targeted drug (cetuximab) during radiation could work as well or better. The goal was to find a treatment that controls the disease while possibly re…

This study tested three ways to treat warts: a topical acid solution, injections of candida antigen (a yeast extract), and a combination of both. 126 people with warts took part. The goal was to see which approach cleared warts best, including warts not directly treated, and how …

This study tested two different injections for treating skin warts caused by HPV. One group received a mix of furosemide and digoxin (drugs usually used for heart conditions), while the other got polidocanol, a standard treatment. Researchers tracked how well each cleared the war…

This study tested whether a gel called Papilocare can help repair cervical lesions caused by HPV. About 200 women aged 30 to 65 with mild cervical changes used either Papilocare or a lactic acid gel for 6 months. The goal was to see if the gel could clear the lesions and the viru…

This study tested whether a vaginal gel called DEFLAGYN, made from silica and citric acid, can help women with unclear cervical smears and high-risk HPV infections clear the virus and avoid surgery. 242 women used the gel for 3 months. The goal was to see if the gel increases the…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This small pilot study tested whether injecting the Gardasil 9 HPV vaccine directly into genital warts could reduce their size and number. Only 2 adults with at least 3 warts each took part. The goal was to see if this approach is safe and worth studying further.

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at 45 patients whose HPV tests came back negative but had a late signal in the raw data. Researchers wanted to see if these late signals might actually indicate early cervical cell changes. By comparing different lab methods, they aim to improve how we interpret…

This study tested a new way to screen for cervical cancer using samples women collect themselves at home. Researchers wanted to see if a test that looks at DNA changes in HPV could better identify who truly needs follow-up care. About 294 women participated, and the goal was to m…

This study tested whether women aged 50 to 65 can collect their own samples for HPV testing to screen for cervical cancer. About 500 women in Cameroon participated. Those who tested positive for HPV then had a Pap smear and other exams to check for precancerous changes. The goal …

This study tested a new mouthwash-based DNA test to see if it can find HPV in saliva, which might help detect HPV-related throat cancer early. Researchers compared results from 360 people — some with throat cancer and some without. The goal was to see how accurate the test is at …

This study tested whether women can collect their own vaginal samples to detect HPV, the virus that causes cervical cancer. Researchers compared self-collected swabs to those taken by a doctor in 222 participants. The goal was to see if self-sampling is accurate and acceptable, w…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether offering at-home HPV self-testing kits can increase cervical cancer screening among women in Appalachia who are overdue for screening. Over 800 women from participating clinics were given either usual care or a self-testing kit along with information and…

This pilot study tested different outreach methods—like automated calls, texts, and emails—to encourage parents in rural areas to get their children (ages 9-17) the HPV vaccine. The study involved 335 parents and caregivers at four community clinics in rural Washington. The main …

This completed pilot study enrolled 101 transgender women and men who have sex with men to see how acceptable the HPV vaccine (Gardasil 9) is in these groups. Participants received three doses over six months, and researchers tracked how many completed the series and how common a…

This study tested whether offering a vaginal self-sampling kit directly to women aged 50-65 who had not had a cervical smear in over three years would increase screening participation. Women received a kit to use at home and mail to a lab for HPV testing. The goal was to see how …

This study in Nigeria looked at whether offering extra health services for teens—like counseling, vision checks, and deworming—alongside the usual government programs could get more 9-year-old girls vaccinated against HPV. Over 12,000 people took part, and researchers compared ar…

This study tested whether culturally tailored multimedia videos could encourage HPV vaccination among Mexican-origin adults aged 18-45 in El Paso, Texas. Participants watched either a culturally tailored or general HPV education video. The goal was to see if the tailored approach…

This study looked at two ways to help doctors talk to families about the HPV vaccine. Some clinics got training from an outside expert, while others learned from a vaccine champion within their own health system. The goal was to see which approach led to more children ages 9-12 g…

This study tested a community-based campaign to increase HPV prevention among 350 mother-daughter pairs in Nigeria. The goal was to get more girls ages 9-14 vaccinated against HPV and more mothers ages 30-65 to do a simple self-test for HPV. The campaign used crowdsourcing to fin…

This study tested whether mailing HPV self-test kits to women who are overdue for cervical cancer screening could increase participation. Over 2,400 underserved women in Texas were randomly assigned to receive a kit or standard phone reminders. The goal was to see if the at-home …

This study looked at how certain enzymes called matrix metalloproteinases (MMPs) and their inhibitors relate to human papillomavirus (HPV) in cervical dysplasia and cancer. Researchers collected tissue and cell samples from 216 women with different stages of cervical lesions. The…

This study tested whether using digital quiz games (Gimkit) or escape room activities helps nursing students learn more about HPV compared to traditional lectures. 90 nursing students took part, and their knowledge and literacy were measured before, after, and later. The goal is …

This completed study tested different messages to see which ones make adults more willing to get the HPV vaccine, which prevents certain cancers. Over 5,300 adults aged 18-45 were randomly assigned to read one of five theory-based messages or a control message. The goal was to fi…

This study looked at how the way we talk about the HPV vaccine affects university students' understanding and willingness to get vaccinated. Researchers gave 177 students either positive messages (focusing on benefits of vaccination) or negative messages (focusing on risks of not…

This study tested a short health game designed for parents and their 11-14 year old children to encourage HPV vaccination. Researchers enrolled 133 families with unvaccinated kids to see if the game was easy to use and acceptable. The goal was to learn if this low-cost approach c…

This study looked at how different messages affect Japanese parents' willingness to get the HPV vaccine for their daughters aged 12-18. Over 1300 parents took part in surveys and experiments. The goal was to find better ways to communicate about the vaccine and increase acceptanc…

This study tested whether a mobile app-based education program could improve women's understanding of HPV and their attitudes toward breast cancer screening. Seventy women aged 30-65 used the app and completed surveys before and after the program. The goal was to see if the app c…

This study surveyed 29 people aged 18-19 in France to find out what they know about human papillomavirus (HPV) and the HPV vaccine. The goal was to identify gaps in knowledge that could be addressed through better education. The results may help improve vaccination rates and info…

This study looked at how often anal high-risk HPV infection and abnormal anal cells occur in men who have sex with men (MSM) who use PrEP to prevent HIV. Researchers collected anal samples and survey data from 304 participants, including both HIV-negative men on PrEP and HIV-posi…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study followed over 46,000 women in the Netherlands who tested positive for HPV and had mild abnormal Pap results. Researchers tracked how many developed cervical cancer within five years. The goal was to see if these women could safely have fewer follow-up tests, making scr…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This completed study looked at how well the HPV vaccine protects against HPV infections over time in over 3,000 Rwandan women aged 18-28, some living with HIV and some without. Researchers collected blood, oral, and other samples to measure vaccine effectiveness and long-term ant…

This study tested a program called Elimisha HPV, designed to reduce stigma and increase cervical cancer screening among women living with HIV in Kenya. The program included simple educational scripts, a video addressing fears, and peer support. Nearly 1,000 women participated, an…

This study tested whether training healthcare providers on HPV and its vaccine improves their knowledge, attitudes, and communication with patients. Researchers recruited 178 providers in the El Paso border region and compared two types of education programs. The goal was to see …