Could a simple gel replace surgery for HPV-Related cervical changes?
NCT ID NCT05509413
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a vaginal gel called DEFLAGYN, made from silica and citric acid, can help women with unclear cervical smears and high-risk HPV infections clear the virus and avoid surgery. 242 women used the gel for 3 months. The goal was to see if the gel increases the rate of HPV clearance and regression of abnormal cells compared to waiting without treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DEFLAGYN vaginal gel (silica and citric acid)
- What this could lead to
- If it works, this could offer a non-surgical, wait-and-see option for women with unclear cervical smears and high-risk HPV, potentially reducing the need for procedures like conization.
- What could go wrong
- This is a completed study with limited prior evidence. The gel is a medical device, not a drug, and its effect may be modest. Side effects were not observed in a prior small trial, but larger studies are needed to confirm benefits.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Marien Hospital Herne
Herne, North Rhine-Westphalia, 44625, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a portable heat device match cryotherapy for cervical precancer?
- Can a daily supplement help the body fight off HPV?
- Could a Light-Activated cream replace surgery for cervical precancer?
- Cervical surgery may alter blood flow to the uterus
- Enzyme-HPV link in cervical disease explored
- Anesthesia choice may change surgical outcomes in cervical treatment