Chronic periodontitis

This study tested whether adding a light-based antibacterial treatment called photodynamic therapy (PDT) to standard deep cleaning improves gum health in people with moderate gum disease. Thirty adults received standard cleaning on one side of the mouth and standard cleaning plus…

This study tested whether adding platelet-rich fibrin (a concentrate from your own blood) plus the antibiotic minocycline works better than the antibiotic Arestin alone for treating gum disease. Fifteen adults with moderate gum disease received both treatments in different parts …

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested a special food-grade formula applied to the gums in 20 adults with chronic gum disease. Researchers observed that gum redness and bleeding improved within 7 to 14 days. The approach aims to repair gum tissue without surgery, but larger and more rigorous studies …

This study looked at whether eating an amla berry (Indian gooseberry) along with standard deep cleaning helps people with chronic gum disease more than cleaning alone. Thirty adults with moderate to severe gum disease were split into two groups: one got cleaning plus amla, the ot…

This study looked at whether non-surgical gum disease treatment could reduce inflammation and improve blood fat levels in young adults with severe periodontitis. Fifty participants (25 with gum disease and 25 healthy) were involved. Those with gum disease received deep cleaning a…

This study tested whether a single dental visit for regenerative root canal treatment works as well as the usual two-visit approach for mature teeth with chronic infection. Thirty-two adults received either a one-session or two-session procedure, and researchers tracked pain duri…

This study tested a home-use device that uses dual-light therapy and a special mouth rinse to help control chronic gum disease. Fifty-six adults with advanced periodontitis used the device regularly. The goal was to see if it reduces gum bleeding and improves plaque control, whic…

This study tested whether adding ozonated olive oil gel or curcumin gel to standard deep cleaning helps treat gum disease (stage II grade B periodontitis). Forty adults completed the 3-month trial. Researchers measured gum attachment levels, plaque, and inflammation to see which …

This study tested a new ultrasonic device with root polishing against standard scaling and root planing for treating gum disease. Forty adults with moderate to severe gum disease were treated and followed for 6 months. The goal was to see which method better reduced pocket depths…

This study looked at whether using a patient's own blood product (L-PRF) can improve bone healing after surgery for a persistent tooth-root infection. Fifteen adults with large infections around the tooth root were treated and followed for 12 months. The goal was to see if adding…

This study tested whether adding laser therapy to standard deep cleaning improves gum health in people with severe periodontitis. Twenty adults received either antimicrobial photodynamic therapy (using a blue dye and laser) or photobiomodulation (red or infrared laser) alongside …

This study tested whether platelet-rich fibrin (PRF), made from a patient's own blood, can improve gum and bone regeneration after standard periodontal surgery. Sixty adults with chronic gum disease and bone defects were randomly assigned to surgery alone or surgery plus PRF. Res…

This study tested a light-activated treatment called Fotosan®630 for severe gum disease (periodontitis). The goal was to see if it could reduce deep gum pockets and infection better than standard care. The trial involved 36 adults with severe chronic periodontitis and followed th…

This study tested if a special light device used at home can help manage chronic periodontitis, a serious gum infection. 202 adults with gum disease used the device regularly to see if it reduced bleeding and improved gum health. The goal was to offer an easy, non-invasive way to…

This study tested three different medications placed inside the tooth root after cleaning to see which one works best for reducing pain, fighting bacteria, and helping bone heal. 45 adults with a single infected tooth took part. The medications compared were N-acetylcysteine, cal…

This study tested three ways to clean infected root canals in 97 people with large tooth infections. The methods were manual movement, ultrasonic vibration, and laser activation. Researchers measured how much the infection shrank over one year using 3D scans. The goal was to find…

This study tested whether a gel made from patients' own blood (injectable platelet-rich fibrin, or i-PRF) could improve healing after standard gum surgery for periodontitis. 42 adults with deep gum pockets received surgery alone or surgery plus i-PRF and a root-cleaning gel. Rese…

This study tested two antibiotic gels (metronidazole and minocycline) in 380 adults with both diabetes and gum disease. Participants received deep cleaning alone or with one or both gels. Researchers checked gum pocket depth and gum color/texture at 7 and 15 days to see which tre…

This study tested two treatments for deep gum bone defects caused by periodontitis: platelet-rich fibrin (PRF), made from the patient's own blood, and enamel matrix derivative (EMD), a protein gel. Twenty-six patients received one of the treatments after surgery, and their gum he…

This study tested a new mouth rinse made with coconut oil and xylitol to see if it could improve gum health in people with periodontitis. 120 adults used the rinse or a placebo three times a day for three weeks. Researchers measured gum appearance and bleeding before and after us…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tested two ways to clean teeth and gums in 82 people with poorly controlled type 2 diabetes and severe gum disease. One method cleaned all teeth in one day (full mouth disinfection), while the other cleaned one quarter of the mouth at a time over four weeks. Researcher…

This study tested a more precise dental surgery for people with persistent root infections after standard treatment. Using a 3D-printed guide, surgeons aimed to remove infected tissue more accurately, reduce surgery time, and improve quality of life. The trial involved 70 adults …

This study looked at 168 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if different root canal shaping tools affect pain after the procedure. Participants received one of four shaping methods, including using a single file or combining files. The…

This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain wa…

This study tested a device called EDDY that uses sound waves to clean root canals better. Forty adults with infected teeth but no pain were treated. The sonic cleaning killed more bacteria than standard methods, but it did not reduce pain after the procedure compared to usual car…

This study looked at 88 healthy adults with infected teeth to see if different irrigation methods during root canal treatment affect pain afterward. Participants had a tooth with a chronic infection and received one of several irrigation techniques. The goal was to find which met…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study looked at three different root canal sealers to see if any caused less pain or helped teeth heal faster. Seventy-two adults with infected single-rooted teeth received standard root canal treatment with one of the sealers. Pain was checked right after, at 24 hours, and …

This study looked at 70 adults with a silent tooth infection (asymptomatic apical periodontitis) to see if the type of sealer used during root canal treatment affects pain afterward. Participants received either a bioceramic sealer (BioRoot RCS) or a resin-based sealer (AH Plus) …

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study looked at 120 adults needing a root canal to see if one sealer (AH Plus or WellRootST) causes less pain afterward. Pain was checked before treatment and at several points up to one month later. The goal is to help dentists choose the better option for patient comfort.

This study tested whether using 3D-guided microsurgery helps bone heal better after a failed root canal compared to standard surgery. It also compared two different filling materials: a newer bioceramic putty and the standard MTA. Twenty-four adults with persistent infections aft…

This study tested whether using a sonic device (EndoActivator) to clean the tooth during a root canal reduces pain afterward. Fifty-eight adults with tooth infections were randomly assigned to get either the sonic cleaning or standard syringe irrigation. Pain was measured before …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study followed 55 people with dental implants for 5 years to see if their history of gum disease (aggressive, chronic, or none) affected implant health. Participants received regular dental cleanings. Researchers measured bone loss, gum inflammation, and implant survival. Th…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study looked at how the types of bacteria in an infected root canal change during routine dental treatment. Twenty-four adults with a chronic tooth abscess received standard root canal therapy using one of two bleach solutions (5.25% or 3% sodium hypochlorite) followed by a …

This study translated a questionnaire that measures how chronic gum disease affects quality of life into Hindi. Researchers tested it on 196 patients with periodontitis to ensure it is accurate and reliable. The goal is to give Hindi-speaking patients a way to report their oral h…

This study tested a new lab method (xCELLigence system) to grow oral biofilms and select the most effective antibiotic for each patient with chronic periodontitis. 64 adults with severe gum disease received standard deep cleaning plus an antibiotic chosen by the new test. The goa…

This study looked at whether injecting a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) could help heal teeth with chronic infection at the root. Sixty adults with infected teeth received standard root canal treatment; half also got the i-PR…

This study examined fluid from deep gum pockets in 30 people with severe periodontitis, both smokers and non-smokers. Researchers measured 40 inflammatory markers before and after non-surgical deep cleaning. The goal was to see which markers change with treatment and whether smok…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study looked at 185 people to compare inflammation markers in those with tooth infections (apical periodontitis), gum disease (chronic periodontitis), and healthy gums. Researchers measured substances like TNF-α and PGE2 in blood and gum fluid. The goal was to better underst…

This pilot study looked at whether certain natural germ-fighting proteins, called antimicrobial peptides, are linked to chronic gum disease. Researchers collected gum smears from 29 adults with moderate to severe periodontitis and from healthy people to compare gene activity. The…

This completed study looked at 108 Turkish adults to see if understanding dental health information is linked to gum health. Participants took a reading test about dentistry and had a dental exam. The goal was to find out if people with lower health literacy have worse gum diseas…

This study measured levels of three metals—chromium, nickel, and magnesium—in the blood of 74 adults. Some had type 2 diabetes and gum disease, some had only one condition, and some were healthy. The goal was to see if these metals are connected to gum health in people with diabe…

This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and …

This completed study looked at how smoking affects gum health in 484 adults. Researchers compared current smokers to non-smokers by measuring plaque, gum bleeding, pocket depth, and gum recession. The goal was to better understand the link between smoking and periodontal disease.

This study looked at whether using a special laser (Nd:YAG) during root canal treatment could help reduce inflammation and oxidative stress in infected teeth. Researchers measured certain markers in fluid samples from 58 patients. The results showed that the laser did not provide…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study measured levels of a protein called NLRP6 in the blood of 50 adults with chronic periodontitis (long-term gum disease). Researchers wanted to see if NLRP6 levels are linked to gum health. The study is complete and aimed at understanding the disease better, not testing …

This completed study looked at two ways to clean below the gumline in 80 adults with early-stage gum disease. One group received Guided Biofilm Therapy, a newer technique, while the other got conventional cleaning with hand tools and an ultrasonic device. Researchers measured gum…

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …