Chronic periodontitis

This study tests a gel made from doxycycline and atorvastatin in tiny chitosan particles, placed directly into gum pockets after standard deep cleaning. The goal is to reduce gum inflammation, pocket depth, and bone loss in 80 adults with moderate to severe chronic periodontitis.…

This study looks at whether adding hyaluronic acid to temporary dental crowns (made by 3D printing or milling) can improve gum health and surface smoothness. Sixty adults with moderate gum disease will receive one of the two crown types, and their gum attachment, bleeding, and pl…

This study tests whether a special irrigation solution called nanochitosan can help regenerate damaged tissue in infected teeth. Sixty adults with dead teeth and chronic infection will receive one of three irrigation methods during a single dental visit. Researchers will check fo…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This study tests whether stem cells taken from donated teeth can be safely injected into the gums to treat periodontitis, a serious gum infection that damages tissue and bone. The goal is to help regrow lost gum and bone without the need for traditional surgery. The trial will en…

This study looks at how well 3D printed bone grafts work for supporting dental implants in people with gum disease or bone loss. Researchers will check if the implants stay stable and how much the graft shrinks over 1 to 6 years. About 100 healthy adults who already received this…

This study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will compare …

This study tests whether using a donor bone graft (allograft) works as well as using your own bone (autograft) to repair defects where a tooth infection has damaged the surrounding bone. Fifty adults with these defects will receive one of the two grafts along with a collagen memb…

This study tests whether a gel made from the diabetes drug metformin can improve gum healing better than a standard antimicrobial gel (chlorhexidine) when used alongside deep cleaning. Sixty adults with moderate gum disease will be split into three groups: cleaning alone, cleanin…

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will measure certain proteins and antioxidants in the fluid from gum pockets in 21 adults with gum disease. Researchers will take samples before and after a deep cleaning procedure (scaling and root planing) to see how these markers change during healing over 3 months.…

This study gathers mouth pictures from 150 adults with different gum conditions to teach an AI system how to spot gum disease. Participants simply have their teeth and gums photographed with a special probe. No treatment or medication is involved—just data collection to improve f…

This study will check if certain gene variations (MMP-2 and MMP-3) are linked to how well the bone around a tooth heals after root canal treatment. Fifty adults with chronic tooth infections will get standard root canal therapy and be followed for 12 months. Researchers will comp…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

This study looks at how much final-year dentistry and psychology students know about gum disease (periodontitis) and whether that knowledge is linked to their own gum health. About 60 students will fill out a questionnaire and get a dental check-up. The goal is to see if more kno…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This pilot study will test whether a weekly injection of a GLP-1 receptor agonist (a type 2 diabetes drug) can improve gum health in 30 adults who have both periodontitis and diabetes. Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility. The goal is…