Cannabis dependence

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This study tested a smartphone app called TECH designed to help court-involved teens reduce or stop using marijuana. The app is a private online community where teens can support each other anonymously. Researchers enrolled 60 teens aged 14-18 who had used marijuana in the past y…

This study tested whether N-acetylcysteine (NAC), an over-the-counter supplement, can help people who use both tobacco and cannabis quit both substances. Fifty-nine regular smokers who also used cannabis took either NAC or a placebo for 8 weeks. Researchers tracked how often they…

This study tested whether giving adults with chronic pain discounted vouchers for medical cannabis soft-gel capsules could help them reduce their opioid painkiller use. 270 participants were randomly assigned to receive vouchers for placebo or cannabis capsules with different THC…

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This pilot study tested a counseling program called the Teen Marijuana Check Up, adapted for young adults (ages 13–35) who have early psychosis and use cannabis. The program uses motivational interviewing and personalized feedback over two sessions to help participants reduce or …

This study looked at whether people with HIV who regularly use cannabis could stop for 28 days and whether that would improve their mood, pain, sleep, and HIV viral load. Twenty-five participants were given financial incentives to stay cannabis-free, with urine tests to confirm. …

This study tested whether a lifestyle physical activity program, using a Fitbit tracker and coaching calls, could help pregnant women at risk for cannabis use reduce their use. Sixteen women who used cannabis at least weekly before pregnancy and had mild depression or anxiety too…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

Researchers at Yale University developed a virtual reality game called Invite Only VR to help middle school students learn about the risks of vaping nicotine and cannabis. In the game, players practice refusing offers to vape in realistic social situations. The study tested the g…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This study looked at whether adding medical cannabis to a behavioral program helps adults with long-term non-cancer pain lower their opioid dose and manage pain better. 87 participants on stable, high-dose opioids were randomly assigned to either start medical cannabis or not, wh…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This small pilot study tested a culturally adapted group therapy called Emotional Awareness and Expression Therapy (EAET) in 6 Israeli adults with chronic musculoskeletal pain who also use medical cannabis. The goal was to see if the therapy could reduce pain and improve emotiona…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study looked at whether a 4-week circuit training program could improve heart and lung fitness in men recovering from drug addiction. Sixty men were split into two groups: one did circuit training (like push-ups, stair climbing, and high knees) three times a week, and the ot…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This early-phase trial tested whether deep transcranial magnetic stimulation (dTMS) targeting specific brain regions is safe and tolerable for people with moderate-to-severe cannabis use disorder. Twelve adults who used cannabis at least four days per week received the stimulatio…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This study looked at a community-based program in Norway that helps people stop using cannabis. The program combines cognitive therapy and education over about 8 weeks. 102 people took part, and researchers measured changes in cannabis use, mental distress, and well-being right a…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This small pilot study tested whether cannabis oil (with different ratios of CBD to THC) could help with insomnia in people who also have major depression. Fourteen adults took either a high-CBD oil, a low-CBD oil, or a placebo for a short time. The main goal was to see if a larg…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and…

This pilot study tested a mobile app called iCanChange in 100 young adults (ages 18-35) with psychosis and cannabis use disorder. The app uses motivational interviewing and cognitive behavioral therapy techniques through short interactive modules. The main goal was to see if the …

This study tested whether CBD (a compound from cannabis) can help people who want to reduce their pain and opioid use. 126 adults took either CBD or a placebo for 12 weeks. Researchers measured changes in pain, opioid use, and other factors like anxiety and sleep.

This completed study looked at whether combining exercise with music can help people recovering from drug addiction. 92 adults in a Chinese rehab center were split into groups: exercise only, exercise with fast music, exercise with slow music, or a control group. Over six months,…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study tests whether suvorexant (Belsomra), a sleep medication, can lower brain activity linked to cannabis cravings. Twenty adults who use cannabis daily will take the drug for 14 days and undergo brain scans before and after. The goal is to see if the medication reduces the…

This study looks at 65 veterans with PTSD who use cannabis frequently. Researchers want to see if reducing cannabis use improves their daily functioning, mental health, and quality of life. No treatment or drug is given—participants simply report their cannabis use and well-being…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study investigates whether chronic cannabis use impairs contrast sensitivity — the ability to see objects clearly against their background, especially when they are moving. Researchers will compare three groups: cannabis addicts, tobacco-only smokers, and non-smokers. Partic…

This study combined brain imaging with real-world data from mobile devices to explore how addiction affects the brain. Researchers scanned the brains of 107 people with alcohol, cannabis, or nicotine dependence, along with healthy controls. They also tracked cravings and daily fu…

This study looked at how different labels on vaping devices (like 'contains nicotine' or 'high potency') affect teens' interest in trying them, their views on health risks, and what effects they expect. Over 3,000 high school students viewed images of vaping devices with various …

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This observational study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in people who regularly use both alcohol and cannabis. 77 heavy drinkers who also smoke cannabis took part, providing blood and stool samples and completing…

This study looked at how different types of cannabis affect memory and brain waves in 96 healthy adults who use cannabis regularly. Participants did a memory task after smoking cannabis and again on a sober day, while their brain activity was recorded with EEG. The goal was to se…

This study looked at how two hormones that rise during pregnancy—estradiol and cortisol—affect the way the body breaks down THC, the main active ingredient in cannabis. Fourteen healthy women of childbearing age took part. Researchers measured THC levels in the blood after taking…

This study looked at how smoking marijuana with different levels of THC affects alcohol cravings and drinking in people who are heavy drinkers and also use marijuana. 157 participants were given either a high-THC, moderate-THC, or placebo marijuana cigarette, then their alcohol c…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This completed Phase 1 study looked at how marijuana and an opioid drug influence each other's use in healthy adults aged 18-50 who had experience with both substances. Eight participants lived at a research unit for about 6.5 weeks and could earn doses of each drug under control…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This completed study looked at how regular cannabis use affects brain health and thinking skills in people with HIV and those without. Researchers used brain scans, blood and spinal fluid tests, and thinking tasks to compare 276 participants. The goal was to understand the combin…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This completed study from the University of Hong Kong looked at 110 cannabis users aged 16-60 to see how their thinking skills change over time and if genes play a role. Participants took memory and thinking tests and gave blood for genetic analysis. The goal is to understand lon…

This completed Phase 1 study at UCLA looked at how smoking cannabis with different amounts of THC and CBD affects drug levels in oral fluid and blood, as well as thinking and feeling. Nineteen adults who use cannabis occasionally took part. The goal was to better understand how t…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This study looked at whether cannabis use affects sperm quality in infertile men. Researchers compared sperm samples from 71 men who used cannabis and those who did not. They measured sperm DNA health and other factors to see if cannabis might be linked to fertility problems.

This study looked at how a pill form of THC (dronabinol) affects sleep and thinking in 18 adults. Some participants used cannabis frequently (more than 3 times a week), while others rarely used it (less than 10 times ever). Researchers measured sleep stages, alertness, memory, an…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This study looked at 40 people who used cannabis within a month before surgery. Researchers used a bedside ultrasound to measure stomach contents and volume, checking if cannabis use leads to delayed stomach emptying. The goal was to better understand how cannabis might affect su…

This study looked at whether cannabis or a similar drug (dronabinol) can improve brain reward function in people with schizophrenia who also use cannabis. 263 participants took part to see if these substances help regulate brain circuits linked to motivation and pleasure. The goa…

This study looked at how cannabis affects memory in people who use it regularly. 121 participants inhaled either a low or high dose of cannabis, or a placebo, and then took a series of memory tests. The goal was to see if cannabis makes it harder to remember things like words, pi…

This study looked at how drinking alcohol and using high-THC cannabis concentrates together affects people. 146 heavy drinkers who also use cannabis regularly took part. Researchers measured things like blood alcohol level, heart rate, and how impaired they felt, depending on whe…

This study looked at how sex hormones and gender influence recovery from cannabis use disorder. 224 adults who wanted to cut down on cannabis received 8 weeks of counseling, including one-on-one goal setting and computerized therapy. They also provided daily saliva samples to tra…

This study looked at how cannabis use affects brain receptors and electrical activity, and how these change when people stop using. Researchers used brain scans and EEGs in 162 people, including cannabis users and healthy controls. The goal was to understand the brain's recovery …

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This early-phase study with 5 adults looked at how two cannabis compounds (delta-9-THC and delta-8-THC) affect driving ability. Participants took the compounds and then used a driving simulator and field sobriety tests. The goal was to see if it's possible to measure impairment a…

This study, completed by Yale University, tested whether a standardized field test can measure marijuana impairment in drivers. 41 participants who use marijuana regularly completed cognitive tasks and simulated driving after smoking either medium-THC or placebo marijuana. The go…

This study tested 30 healthy adults to see how Delta-8-THC and Delta-9-THC affect driving in a simulator. Participants took the drugs by vaping or eating, then performed driving and sobriety tests. The goal is to understand how Delta-8 impairs driving compared to Delta-9, helping…