Cannabis dependence

This 12-week study tests whether a weekly injection of tirzepatide, a drug used for diabetes, combined with motivational therapy can help adults with moderate to severe cannabis use disorder. Fifteen participants will receive escalating doses of tirzepatide along with counseling.…

This study will test whether cannabis can reduce the severity of opioid withdrawal and make opioid use safer. One hundred adults with opioid use disorder will live in a hospital for about six weeks. Researchers will give them cannabis and a small dose of opioids to see how their …

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study tests whether cannabis-based treatments can safely reduce seizures in people aged 2 to 55 with drug-resistant epilepsy. Participants will receive either a pure CBD extract, a CBD-rich herbal cannabis extract, or a placebo. The goal is to see if these treatments lower m…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can strengthen a brain circuit linked to staying away from cannabis. Fifty treatment-seeking youth aged 15–21 with cannabis use disorder will receive either real or sham rTMS. Researchers will chec…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests a medicine called tirzepatide to see if it can help people with moderate to severe cannabis use disorder use less cannabis or stop altogether. One hundred adults aged 18 to 70 will receive either the drug or a placebo, and researchers will track their cannabis us…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This pilot study tests whether tirzepatide, a drug used for diabetes, can reduce cravings in people with severe cannabis use disorder. Six adults will receive either tirzepatide or a placebo injection and then be exposed to cannabis-related cues to measure craving intensity. The …

This study tests a talking therapy called the Cannabis Clinic for Psychosis (CCP) to help people with first-episode psychosis reduce or stop cannabis use. The therapy includes motivational interviewing and cognitive behavioral therapy in weekly sessions over 12 weeks. Researchers…

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests LaunchPad, an online program designed to help high school seniors avoid drug and alcohol problems as they leave school. Researchers will randomly assign 5,000 students to different lessons and measure changes in their attitudes, confidence, and intentions around …

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests whether cannabidiol (CBD) can reduce the need for strong painkillers (opioids) in people with end-stage prostate cancer that has spread and no longer responds to standard treatments. About 58 participants will receive either CBD or a placebo three times daily for…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study is for pregnant people who use tobacco and cannabis and want to quit. Researchers will test a program that helps with depressive symptoms to make quitting easier. The study involves 25 participants and will measure how well the program works and if people stick with it…

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This study tests a cannabis plant extract called NTI164, which has very low THC (the compound that causes a high), in 40 females aged 4-25 with Rett syndrome, a rare genetic condition causing severe physical and mental challenges. Participants will receive either NTI164 or a plac…

This study tests whether a full-spectrum cannabis plant extract called NTI164 can help reduce core autism symptoms (like social challenges and repetitive behaviors) in children and young adults aged 6 to 25. About 98 participants will receive either NTI164 or a placebo for 16 wee…

This study tests whether a high-CBD cannabis extract is safe and helps relieve symptoms in people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effec…

This study looks at whether cannabis can help veterans who have PTSD and thoughts of suicide. About 500 veterans who have used cannabis in the past year will take part. Researchers will track changes in PTSD symptoms, mood, and suicide risk over time using interviews and question…

This study will test whether cannabis can reduce the desire to take opioids in people with opioid use disorder. Thirty participants will live in a hospital for six weeks and receive either cannabis or a placebo, along with opioids. Researchers will measure how many times particip…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study looks at how using nicotine vapes before or after THC vapes changes the amount of THC that enters the bloodstream. Researchers will compare THC levels and effects in 60 adults who regularly use both products. The goal is to understand safety and how these products work…

This study will test 35 people with known or suspected allergies to cannabis, tree nuts, or seeds to see if they are also allergic to hemp seeds. Participants will receive skin prick tests and blood tests to measure allergic reactions. The goal is to understand the potential alle…

This study aims to improve a short motivational conversation to help young adults (ages 18-25) who were injured in an assault and also misuse alcohol or cannabis. Researchers will interview and survey 50 participants from a hospital violence intervention program to understand how…

This study looks at how a moderate dose of THC (the active part of cannabis) affects mood, stress, and thinking in people who use cannabis at least once a week. Ninety adults will take part in two sessions—one with active cannabis and one with a placebo—without knowing which they…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention. Researchers will test 40 adults—some who use cannabis often and some who use it rarely—to see if eye-tracking can reliably detect impairment. The goal is to deve…

This early-stage study will test how a hemp-based CBD lotion with a small amount of THC is absorbed by the body. Twenty healthy adults will use the lotion in a clean, controlled environment. Researchers will measure cannabinoid levels in saliva, blood, and urine over time to unde…

This study will test 70 healthy adults aged 21-55 to see how cannabis products labeled as indica, sativa, or generic affect thinking, driving, and feelings. Participants will complete memory tasks, driving simulations, and questionnaires after using cannabis. The goal is to under…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study will follow 120 people with schizophrenia who use cannabis, using mobile phone surveys and thinking tasks to track symptoms in real time. The goal is to understand how cannabis may both worsen positive symptoms (like hallucinations) and reduce negative symptoms (like l…

This study looks at whether cannabidiol (CBD) can reduce the amount of THC heavy cannabis users need to feel intoxicated. About 30 adults who use cannabis heavily will take a single dose of CBD or a placebo, then inhale THC using a vaporiser and decide when they've had enough. Re…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study tests whether a brief education session about cannabis risks can increase knowledge and motivation to reduce use among people with eating disorders. 80 patients will receive either cannabis education or sleep hygiene education during their first week of a 20-week eatin…

This study looks at how different amounts of oral THC (the main psychoactive ingredient in cannabis) affect mood, heart rate, and drug feelings in healthy adults who have used cannabis before. Participants will take either a low, medium, or high dose of THC or a placebo during fo…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study will give 80 healthy adults who use cannabis occasionally different low doses of inhaled CBD (5 to 100 mg) or a placebo to see if they feel a pleasant effect. Each person will try all doses in a random order, and researchers will also explore if current tools miss any …