Johns Hopkins University

This study tests whether a 2-month combination of TB drugs can cure children under 10 with drug-susceptible tuberculosis as safely and effectively as the standard 4-6 month treatment. About 860 children will take part. If successful, the shorter regimen could make treatment easie…

This study tests two ways to increase COVID-19 vaccination among Latino adults and their social networks. One group learns motivational interviewing skills to encourage their friends to get vaccinated, while the other group just receives vaccine information. Researchers will comp…

This study tests whether one or two doses of the RSV vaccine Arexvy works better in people with weakened immune systems, such as those who have had a cell transplant. Participants will receive up to three vaccine doses over a year and be monitored for side effects and immune resp…

This study compares getting flap surgery within 72 hours of a severe lower leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will ta…

This study tests a computer program where an avatar guides people through quitting smoking, plus a community health worker helps connect them to lung cancer screening. It involves 30 adults aged 50+ who smoke and are considering quitting. The goal is to see if this approach is ac…

This study looks at whether a surgeon-initiated referral to a bone health specialist can reduce implant problems and fractures in people with osteoporosis who have hip or knee replacement surgery. About 2,000 participants aged 50 and older with confirmed osteoporosis will be foll…

This study looks at ways to help adolescents and young adults with HIV get the virus under control. It helps them choose the best treatment, including long-acting shots, and removes barriers to getting it. The goal is to help more young people reach and keep an undetectable viral…

This study tests a short, computer-based relapse prevention program for 150 adults with HIV and alcohol use disorder. Participants will receive two sessions designed to help them avoid returning to risky drinking. The goal is to see if the program helps people stay alcohol-free l…

This study follows 80 pregnant women whose babies have a severe diaphragmatic hernia, a condition where abdominal organs move into the chest and harm lung growth. Half receive a procedure called FETO, which temporarily blocks the windpipe to help lungs expand, while the other hal…

This study tests whether treating drug-resistant tuberculosis (TB) with nurse-led care at local clinics works as well as standard doctor-led care at hospitals. About 2,944 people will take part in South Africa. The goal is to make treatment easier to access and lower the financia…

This study tests whether a drug used for diabetes can slow brain and eye damage in people with multiple sclerosis (MS). About 120 adults with stable MS will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug reduces brain shrinkage and inflammation,…

This study looks at whether children aged 1 to 17 with controlled eczema can safely take less dupilumab or stop it entirely. About 30 kids who have been on the drug for at least a year will be randomly assigned to reduce their dose or stop treatment. The goal is to see if they ca…

This small pilot study tests whether deep brain stimulation (DBS) can help people with severe schizophrenia that hasn't improved with multiple medications. Researchers will implant electrodes in a specific brain area to try to reduce persistent hallucinations and delusions. The s…

This study tests a program called PICU Up! that helps critically ill children start moving early, while also managing sedation, preventing delirium, and promoting sleep. About 1,440 children on breathing machines will take part across 10 U.S. hospitals. The goal is to see if this…

This study tests a brain implant that records and stimulates brain areas to help people with severe paralysis control assistive devices like computers or wheelchairs. It also aims to provide sensory feedback. The trial enrolls 5 adults with conditions like spinal cord injury or A…

This study tests a device that electrically stimulates the balance nerve to help older adults (ages 65-90) with severe, long-term dizziness and unsteadiness. The implant aims to improve walking, posture, and vision stability. Fifteen participants will be followed for six months t…

This study tests if tesamorelin can help nerves regrow and muscles recover after a serious nerve injury in the arm. About 36 adults with a cut ulnar nerve at the wrist will either get tesamorelin or no extra treatment after surgery. Researchers will check pinch strength, hand fun…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help adults with obesity and binge-eating disorder reduce binge episodes and lose weight. About 105 participants will receive tirzepatide, a placebo, or another drug (lisdexamfetamine), plus guide…

This study tests if a two-drug HIV regimen (dolutegravir/lamivudine) works as well as the standard three-drug regimen for people starting HIV treatment while also being treated for tuberculosis. About 150 adults with both HIV and TB will take one of three pill combinations for 48…

This study tests whether adding a person's own concentrated bone marrow cells to standard hip decompression surgery can stop or slow the bone death that leads to hip collapse. It includes 192 adults with early-stage osteonecrosis (before the hip ball collapses). The goal is to pr…

This study tests a program called Full-SPARCS for 400 people with HIV who are leaving prison in South Africa. The program uses peer support and structured antiretroviral therapy to help them stay in care and keep the virus under control. Researchers will compare this approach to …

This study tests whether giving newborns a nasal microbiome transplant from a parent can increase the diversity of bacteria in the baby's nose. The goal is to see if this can help prevent infections like Staphylococcus aureus. The study involves 175 premature babies in the NICU a…

This study tests whether eating more omega-3 (found in fish and certain oils) can improve breathing and daily life for people with COPD. Researchers will provide food to 200 adults with moderate-to-severe COPD and track their health over time. The goal is to see if a simple diet …

This study tests whether providing medically tailored meals and fresh food delivery can help Black women who had gestational diabetes control their weight after childbirth and lower their risk of developing type 2 diabetes. About 40 low-income new mothers will receive either prep…

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and heart disease risk. The program includes a smartphone app, doctor education, and better clinic workflows to help patients reach their cholesterol goals. Researchers …

This study tests whether people with atrial fibrillation (AF) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults aged 22-85 with AF and low-to-moderate stroke risk will be randomly assigned to either standard daily blo…

This study tests whether omalizumab, an allergy drug, can reduce serious lung flare-ups in people with COPD who also have allergies. About 334 adults over age 40 with a history of smoking and COPD will receive the drug or a placebo for 12 months. The goal is to see if the drug lo…

This study tests a device that electrically stimulates the balance nerve to help people with severe, long-term dizziness and unsteadiness. The implant aims to improve posture, walking, and vision stability. The trial includes up to 8 adults aged 22-90 whose condition did not impr…

This study tests whether sildenafil (the drug in Viagra) can help people with scleroderma who have mildly high blood pressure in their lungs. About 30 participants will receive either sildenafil or a placebo for 4 months. The main goal is to see if they can walk farther in a 6-mi…

This study looks at whether aspirin can reduce inflammation and improve breathing in people with COPD, a serious lung disease. Researchers will test different daily doses of aspirin in 48 former smokers to find the dose that best blocks overactive blood cells linked to inflammati…

This study will test whether a new ultra-high resolution CT scanner can find blocked heart arteries more accurately than a standard CT. About 140 adults with suspected coronary heart disease will get one ultra-sharp CT scan, and the images will be compared to a standard CT made f…

This study tests whether training people who inject drugs to become peer educators can help their friends get tested for HIV and start prevention tools like PrEP or treatment for opioid use. About 360 participants from syringe service programs in Maryland will be split into two g…

This study tests a mobile van approach to offer HIV/STI testing and connect men who have sex with men (MSM) aged 18-49 in Baltimore to PrEP or HIV care. Participants are assigned to either get help from a peer health navigator or receive standard referrals. The goal is to see if …

This study is for people who have shoulder pain after a stroke. It tests if injecting a natural substance called hyaluronic acid into the shoulder muscles can reduce pain and improve movement. About 68 adults who had a stroke 3 months to 15 years ago will take part. The goal is t…

This study tests two different types of talk therapy—cognitive behavioral therapy and mindfulness-based therapy—to see which works better for improving sleep and easing depression and PTSD symptoms in people who have had a mild or moderate traumatic brain injury. The therapies ar…

This study tests whether a mobile health program (mPATH) can improve memory and sleep in low-income older adults who are not very active and have trouble sleeping. Participants will use a smartphone app to guide physical activity. The goal is to see if this approach helps their t…

This study tests whether a daily oral dose of cannabidiol (CBD), a compound from cannabis, can help people stop smoking tobacco. Fifty adults who smoke more than 10 cigarettes a day and want to quit will take CBD or a placebo during several practice quit attempts over 6 weeks. Re…

This study tests whether the drug vortioxetine can improve mood symptoms and thinking skills in people with early-stage behavioral variant frontotemporal dementia (bvFTD). About 50 participants will take vortioxetine for 12 weeks and undergo brain scans and cognitive tests before…

This study tests a 8-10 week program for caregivers with disabilities who care for a loved one. The program offers personalized help with resources, self-care, emergency planning, and peer support. The goal is to reduce stress, burden, and depression. About 20 adults in Maryland …

This study looks at whether playing music helps children with glaucoma pay better attention during a visual field exam (a test that maps their side vision). About 40 kids will take the test with or without music, and doctors will measure how often they miss signals or get distrac…

This study tests whether vestibular therapy—exercises for the inner ear balance system—can reduce falls in people with Alzheimer's disease. About 100 older adults with mild to moderate Alzheimer's and balance problems will receive either the therapy or a control activity. Researc…

This study aims to reduce vertigo and dizziness people feel when entering high-field MRI machines. Researchers will test slower entry speeds (1-3 minutes instead of the usual 20 seconds) in 100 participants already scheduled for an MRI. The goal is to see if a gentler pace can pr…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can help improve mood and quality of life in people with ALS who feel depressed. About 24 adults with ALS will receive the therapy in a controlled setting. The goal is to see if this approach is practi…

This study looks at whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke cigarettes. About 90 smokers will receive CBD and then be exposed to stress in a lab setting. Researchers will measure mood, stress hormones, and vital signs to se…

This study tests whether a low-dose, slow-release form of levetiracetam (AGB101) can reduce overactivity in a key memory region of the brain in healthy older adults. Overactivity in this area is linked to higher dementia risk. Sixty participants aged 50-80 will receive both the d…

This study looks at two ways to help teenagers reduce their alcohol use. One group gets a short counseling session, and the other gets the same session plus a smartphone app that teaches mindfulness. The goal is to see if the app helps teens drink less and have fewer alcohol-rela…

This study looks at whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with both chronic low back pain and depression. About 40 adults will receive either psilocybin or a control drug, then complete surveys and tests over one month…

This study tests a self-administered rehabilitation tool that gently guides people to move their heads more to reduce motion sickness and help with balance recovery. It is for adults with inner ear disorders, motion sickness, or after certain ear surgeries. The tool is used at ho…

This study tests whether adding virtual reality (VR) to standard relaxation exercises helps burn survivors manage long-term symptoms like pain, itch, anxiety, and poor sleep. About 34 adults who had a burn injury at least 6 months ago will try both VR-enhanced and standard relaxa…

This study tests a digital program designed to help immigrant women who have experienced violence and struggle with PTSD or depression. The program focuses on reducing stress, improving safety, and building self-care habits. Researchers will track changes in stress, mood, and pro…

This study tests whether the sleep medication trazodone can improve sleep and memory in people with early Alzheimer's disease and sleep problems. Researchers will compare trazodone to a placebo in 100 participants. The goal is to see if better sleep can slow memory decline.

This study tests a program called CAPABLE Transplant to help people with kidney failure who are waiting for a transplant. The program addresses barriers like frailty, depression, and lack of support to help them become active on the waitlist. About 43 adults will participate to s…

This study looks at 250 women who have had early-stage breast cancer and are now overweight and have trouble sleeping. Researchers want to see if a short program to improve sleep (called CBT-I) before starting a weight loss program helps them lose more weight than just learning a…

This study tests whether wearing special tape over the mouth while sleeping can reduce snoring and improve sleep quality. About 100 adults with snoring or mild sleep apnea will try the tape at home. Researchers will measure snoring, sleep quality, and how easy the tape is to use.

This study compares Scrambler Therapy, a non-drug treatment that uses mild electrical signals to block pain, to standard pain medications for people who have ongoing pain after a stroke. Researchers want to see if this therapy can reduce pain by at least half. The study will enro…

This study compares two surgical methods for removing the bladder in men with bladder cancer. The goal is to see which approach better preserves erectile function and urinary control. About 70 men will be randomly assigned to one of the two surgeries and will complete questionnai…

This study tests if scrambler therapy, a non-invasive nerve stimulation treatment, can reduce pain in people with corticobasal syndrome (CBS), a rare brain disease. About 25 adults with CBS and daily pain will receive either scrambler therapy or standard TENS treatment. The goal …

This study tests a low-dose drug called AGB101 to see if it can reduce hallucinations and delusions in people with Parkinson's disease. About 30 adults aged 40-85 will take the drug and a placebo at different times, with brain scans and questionnaires to track changes. The goal i…

This study tests a special laser to see if it can safely improve the rough bumps and redness caused by keratosis pilaris (KP), a common but harmless skin condition. About 25 adults with KP on both upper arms will receive the laser treatment. Researchers will check results using p…

This study tests three new pulse oximeters (devices that measure oxygen levels) in 1,200 children under 2 years old with pneumonia in Cape Town, South Africa. The goal is to see if these devices help healthcare workers correctly identify low oxygen levels and refer children for p…

This study looks at 1000 healthy people aged 25 to 35 to understand how their body, environment, and overall lung health affect the structure of their airways and blood vessels, as well as how well their lungs exchange gases. Participants will take four simple breathing tests. Th…

This study aims to understand how adults who survive acute respiratory failure (ARF) and their family caregivers think about the first 6 months of recovery. Researchers want to see if expectations about recovery are linked to anxiety, depression, and stress in both survivors and …

This study looks at whether detailed heart scans (MRI) can better predict who is at risk for sudden cardiac death compared to the usual method of measuring heart pumping strength. Researchers will follow 400 people with weak hearts who are getting a defibrillator (ICD) to see if …

This study tests whether a text-messaging program for first-time fathers can improve their confidence and involvement during pregnancy and early infancy. Researchers will recruit 180 dads-to-be across the U.S. using social media. The goal is to support fathers, mothers, and babie…

This study compares group-based postpartum and well-child care to standard individual checkups for mothers and their infants. Researchers will measure outcomes like postpartum depression and vaccination rates in 1,125 participants in Malawi. The goal is to see if group care impro…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis. The goal is to understand the role of certain proteins in this process. About 140 women aged 18-…

This study tests a new device that continuously measures pressure in the leg to detect compartment syndrome—a condition where blood flow is cut off—in patients on ECMO life support. Because these patients are sedated and can't report symptoms, early diagnosis is hard. The study w…

This study tests whether a new electronic tool and special communication training can help doctors better discuss safe sleep practices with parents during baby checkups. Researchers will compare families whose doctors use the tool to those receiving standard care. The goal is to …

This study is testing whether new MRI and CT scans can better identify people at high risk for sudden cardiac death. Researchers will enroll 400 adults with weak hearts (ejection fraction 35% or less) who are scheduled to get an implantable defibrillator (ICD). The goal is to imp…

This study is for people with non-muscle invasive bladder cancer who are getting BCG treatment. Researchers want to see if the treatment causes mood changes. Participants will provide blood and urine samples, answer questionnaires, and keep a daily mood diary. The goal is to bett…

This study is checking if very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) are safe for healthy people to take at home. Twenty healthy adults will receive increasing doses and a placebo on different days in a lab, while doctors monitor their blo…

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes and their body's reactions. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. They will measure things like h…

This study uses a special MRI technique to measure the heart's energy levels without needles or biopsies. Researchers want to see if low energy in the heart muscle causes poor pumping in heart failure. About 500 adults—healthy volunteers and those with heart disease—will be scann…

This study tests a program called Communities Care, which aims to change harmful social norms that lead to violence against women and girls in Somalia. Researchers will work with about 3,500 adults and adolescents (ages 10 and older) in two regions, comparing communities that rec…

This study looks at how the immune system of adults over 75 responds to the annual flu shot. Researchers want to know if a common virus called CMV affects that response. About 1,025 healthy or frail older adults will join, and participants receive the flu vaccine for free along w…

This early-phase study tests whether transferring a parent's nasal bacteria to a child can restore the child's nasal microbiome diversity after they've been treated with antibiotics for staph bacteria. About 175 children under 18 who recently completed staph treatment will receiv…

This study follows 1,500 people with heart failure who are getting a replacement for their implantable defibrillator (ICD). Researchers want to learn why some people have dangerous heart rhythms and how to better predict sudden cardiac death. Participants will provide medical dat…

This study looks at how many people visiting emergency rooms in South Africa have HIV or are at high risk of getting it. Researchers will offer HIV tests to all patients and help those who test positive or are at risk get connected to long-term care or prevention medicine (PrEP).…

This study is creating a database (registry) of up to 1,500 people with achondroplasia, a common form of dwarfism. Researchers will collect information from medical records, such as growth measurements and surgeries, to better understand the condition and improve future care. Par…

This study is testing a program called CAPABLE, which is added to regular home-based primary care for older adults who are homebound and may feel socially isolated or lonely. The goal is to see if this combined approach can improve their daily function, reduce pain and depression…

This study looks at how psilocybin, the active ingredient in magic mushrooms, affects thinking and brain activity. Researchers will give the drug to 30 healthy adults and use brain scans and computer tasks to measure changes. The goal is to understand how psilocybin alters though…

This study looks at how commercial kratom extract products affect mood, thinking, and physical signs like heart rate and pupil size in adults who use them regularly. Researchers will also interview participants about their experiences. The goal is to better understand these produ…

This study looks at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (an irregular heartbeat). Researchers want to see if more scarring leads to worse outcomes after a common treatment called ablation. About 100 adults schedule…

This study follows 4,000 adults aged 25-35 without severe lung disease over many years. The goal is to learn what healthy lungs look like and find early warning signs of chronic lung disease. Participants will have breathing tests and other check-ups to track lung function over t…

This study looks at whether eating dinner earlier in the day helps the body burn fat and control blood sugar better than eating late. Researchers will compare two groups: healthy-weight adults and those with obesity and prediabetes. Participants will eat either an early or late d…

This study looks at why some children develop obesity by examining brain activity, eating behaviors, and genetics. Researchers will measure how kids' brains respond to food and how that relates to their weight. The goal is to find early clues that could lead to better ways to pre…

This study looks at how different forms of cannabis edibles—chocolates, gummies, and drinks—affect thinking, behavior, and blood levels. Healthy adults aged 21-55 will take part in 9 sessions, each involving an overnight stay and tests of memory, attention, and driving skills. Th…

This study tests a program called Heart-to-Heart, where a community health worker helps heart patients with low income decide whether to join cardiac rehab. The goal is to see if the program is practical and if patients like it. About 50 people from Johns Hopkins Hospital will ta…

This study is building a database of 400 children and young adults with eczema who have used or will start systemic (whole-body) treatments. Researchers will track how well these treatments work and any side effects by reviewing medical records and patient surveys. The goal is to…

This study looks at how a commercially available ketone drink (Ketone-IQ) affects sleep and breathing in 20 healthy adults. Participants will take two different doses before bed at home and report on sleep quality and any stomach issues. The goal is to understand how the body res…

This study aims to find better ways to detect pancreas cancer early in people at high risk due to family history or genetic mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 volunteers during routine endoscopy. The goal is to identify mark…