Johns Hopkins University

This study tests whether emetine, an old drug, can help adults with dengue fever avoid severe illness or death. About 600 hospitalized patients aged 18-65 will take either a low or high dose of emetine or a placebo pill for 7 days. Researchers will monitor their symptoms and bloo…

This study looks at whether using a low sodium salt substitute is safe for adults with high blood pressure who are on medication. About 607 participants in Bangladesh will replace regular salt with the substitute and be monitored for changes in potassium levels and blood pressure…

This study tests whether a program led by community health volunteers can help people in Bhaktapur, Nepal breathe better. The program focuses on reducing tobacco smoke and air pollution, preventing respiratory infections, and encouraging safe physical activity. About 800 people w…

This study tests whether an AI-powered stethoscope can help doctors in rural Bangladesh safely reduce antibiotic use in children with pneumonia. About 2,500 children will be randomly assigned to standard care or care guided by the AI stethoscope. The goal is to see if the AI tool…

This study tests whether a 4-week course of the drug bedaquiline can prevent tuberculosis (TB) as well as the standard longer treatments. It involves 2,530 people living with HIV and close contacts of TB patients. The goal is to find a safer, shorter, and easier prevention option…

This small pilot study tests whether N-acetylcysteine (NAC), a supplement that reduces oxidative stress, can lessen repetitive and self-injurious behaviors in people with Cornelia de Lange Syndrome (CdLS). Ten participants aged 13 to 35 will receive both NAC and a placebo at diff…

This early study tests whether applying a nitropaste cream during high-risk leg surgeries (like ankle or heel fractures) can improve blood flow to the wound area. Researchers will use a special camera to measure blood flow during surgery and then watch for wound healing problems …

This study tests whether cannabidiol (CBD) can reduce withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. About 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care, and have their symptoms, sl…

This study tests a biofeedback breathing system called Freespira in 73 youth aged 9-17 with anxiety or panic disorders. Participants use the device to learn breathing techniques that may reduce symptoms. The goal is to see if it lowers anxiety scores on a standard child anxiety q…

This early-stage study tests if a shortened LSD experience, followed by the drug risperidone, is safe and helps reduce symptoms of major depression. Ten adults with moderate to severe depression will receive the treatment. Researchers will track changes in depression scores and w…

This early study tests whether blocking the middle meningeal arteries (using a plug-like material called Onyx) is safe and possible for people with hard-to-treat chronic migraines. The idea is that blocking these arteries may reduce migraine-triggering substances reaching the bra…

This study tests whether 8 nurse home visits can help older adults (50+) who have ongoing pain, depressive symptoms, and trouble moving around. The nurses will work with participants on managing pain and mood. The goal is to see if this approach reduces pain intensity, pain inter…

This study tests whether a personalized, non-invasive brain stimulation device can improve memory and language in 10 adults with primary progressive aphasia (PPA), a condition that slowly destroys the ability to speak and understand. The device uses AI to tailor electrical stimul…

This study looks at how THC (the main psychoactive part of cannabis) and beta-myrcene (a natural compound found in many plants) work together when inhaled. Researchers will measure how these substances affect participants' feelings and tiredness. The goal is to better understand …

This study looks at whether a 50-minute education session is practical and helpful for pregnant and postpartum women being treated for opioid dependency, along with a support person they choose. The session provides correct information about medications and newborn withdrawal. Re…

This study looks at how cannabis products labeled as indica, sativa, or generic affect people's thinking, driving, and feelings. Researchers will test 70 healthy adults aged 21-55 to see if different strains cause different effects. The goal is to understand if strain labels actu…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention. Researchers will test 40 adults—some who use cannabis often and some who use it rarely—to see if eye-tracking can reliably detect impairment. The goal is to deve…

This study tests whether a short questionnaire before a doctor's visit helps Black parents of preterm babies with chronic lung disease set and achieve goals for their child's care. About 30 parents will try the tool and share feedback. The goal is to see if this approach is pract…