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Could a heart ointment help heal leg wounds after surgery?

NCT ID NCT07004764

Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests whether applying nitroglycerin ointment (a medicine that widens blood vessels) to surgical wounds during high-risk leg surgeries can improve blood flow and reduce complications like infection or wound separation. Fifteen adults undergoing specific ankle, heel, or shinbone surgeries will receive the ointment, and blood flow will be measured with a special imaging system. The goal is to see if this simple approach is worth testing in larger trials.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nitroglycerin ointment 2%
What this could lead to
If it works, this could point toward a simple way to improve wound healing and reduce infections after high-risk leg surgeries.
What could go wrong
This is a very small, early feasibility study with only 15 participants. It may not show a clear benefit, and nitroglycerin can cause side effects like headache or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Undergoing surgery for one of the following procedures: * Current Procedural Terminology (CPT) 28415 - Open reduction calcaneal fracture ± internal/external fixation * CPT-27814 - Open reduction of bimalleolar fracture ± internal/external fixation * CPT-27822 - Open reduction trimalleolar ankle fracture, medial and lateral malleoli only, ± internal/external fix * CPT-27823 - Open reduction trimalleolar ankle fracture, including posterior malleolus, ± internal/external fix * CPT-27826 - Open reduction pilon fracture, internal/external fixation of fibula ONLY * CPT-27827 - Open reduction pilon fracture, internal/external fixation of tibia ONLY * CPT-27828 - Open reduction pilon fracture, internal/external fixation of tibia AND fibula * CPT-27535 - Open reduction unicondylar tibial plateau fracture, ± internal/external fixation * CPT-27536 - Open reduction bicondylar tibial plateau fracture, ± internal/external fixation * CPT-28445 - Open reduction of talus fracture, ± internal/external fixation * CPT-27650 - Primary Achilles tendon repair * English-speaking * Able to provide informed consent during preoperative clinic visit, in the preoperative nursing area, or on inpatient units. Exclusion Criteria: * Contraindications to nitroglycerin, including known allergy. * Allergy to indocyanine green or components of ICG dye, including allergies to iodine or shell-fish. * Severe kidney injury, as determined by attending surgeon and/or anesthesiologist, that would impair clearance of ICG dye. * Pregnant patients

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Conditions

The condition(s) this trial relates to.

Ankle Fractures Surgical Wound Dehiscence tibia fracture Tibial Plateau Fractures Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Achilles tendon repairs/reconstructions Ankle fracture (bimalleolar equivalent, bimalleolar, or trimalleolar) Calcaneus fractures Pilon fracture of tibia Talus fracture Tibial plateau fracture Wound dehiscence, surgical Wound infection deep Wound infection post-traumatic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Johns Hopkins Bayview Medical Center

    Baltimore, Maryland, 21224, United States

  • The Johns Hopkins Hospital

    Baltimore, Maryland, 21201, United States

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