Johns Hopkins University

This study looks at whether tetracycline, an antibiotic, is tolerable and can help people with Post-Treatment Lyme Disease (PTLD) — ongoing symptoms like fatigue after standard Lyme treatment. About 60 adults will receive either tetracycline or a placebo for 3 months, then switch…

This study tests a new, less invasive surgery for unborn babies with spina bifida. Instead of opening the mother's belly and uterus, doctors use a tiny camera and tools through small cuts to repair the baby's spine while still in the womb. The goal is to fix the spinal defect and…

This study aimed to see if adding a single high dose of psilocybin (30 mg) to standard buprenorphine treatment could help people with opioid use disorder stay off illicit opioids and improve their quality of life. It was designed for adults aged 21-70 who were not already on opio…

This study compares two treatment strategies for people with relapsing-remitting multiple sclerosis: starting with a strong, high-efficacy drug right away versus starting with a milder first-line therapy and switching only if needed. The goal is to see which approach better preve…

This study looks at the long-term safety of an antioxidant called N-Acetylcysteine (NAC) in 30 adults with retinitis pigmentosa, a genetic eye disease that leads to vision loss and blindness. Participants take NAC tablets twice a day for up to 12 months. The goal is to see if NAC…

This study looks at 22 adults with epilepsy who have been on a modified Atkins diet for at least a year and have high cholesterol. Researchers want to see if changing the diet or adding a statin drug can safely lower cholesterol without causing seizures or making people stop the …

This study tests a new drug called MW189 in 120 people who have had a brain bleed (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling, which often causes further damage. Participants receive the drug within 24 hours of their stroke and…

This study looks at whether it is safe for people with HIV to receive a liver transplant from a donor who also has HIV. About 80 participants will be followed to track major problems like organ failure, serious side effects, or HIV complications. The goal is to see if using HIV-p…

This study tests a program that combines home blood pressure monitors with a smartphone app and support from community health workers. About 600 adults with slightly high blood pressure who are not yet on medication will take part. The goal is to see if this approach helps keep b…

This phase 3 trial tests whether an oral antioxidant called N-acetylcysteine (NAC) can slow the loss of vision in people with retinitis pigmentosa, an inherited eye disease that causes night blindness and tunnel vision. About 485 adults aged 18 to 65 will take NAC or a placebo da…

This study tests an experimental treatment for pregnant women whose babies have no amniotic fluid because of severe kidney problems. The treatment involves repeatedly adding sterile fluid into the womb to help the baby's lungs grow enough to survive after birth. The study include…

This early study tests whether giving a newborn a small dose of their parent's healthy nasal bacteria can help prevent staph infections. The trial involves 34 infants in the NICU and their parents. Researchers will check if the baby's nose bacteria become more diverse and resista…

This study looks at whether new ultrasound signal processing can make breast images clearer, helping doctors spot microcalcifications, cysts, and masses more accurately. About 252 women with certain breast findings will get standard and experimental ultrasound scans. The goal is …

This study enrolls 150 young women aged 13–25 in Baltimore who have pelvic inflammatory disease (PID). Half receive standard care; the other half also get home visits from a community health nurse and text message support for 30 days, plus extra testing and treatment. The goal is…

This study tests a new tool that helps doctors give personalized advice to people with prediabetes. About 100 participants will answer a questionnaire about their readiness to make healthy changes. Based on their answers, the tool suggests ways for doctors to support them, like r…

This study tests a program called ACTFAST in three trauma centers to help prevent firearm injuries. It will involve about 1,776 adult patients who are admitted for injuries. The program includes screening, brief counseling, and referrals to promote safe firearm storage and reduce…

This study tests whether collecting sexual health information electronically during routine gynecologist visits helps more women at risk for HIV get prevention medication (PrEP). About 1,170 women aged 15-65 attending well-woman exams will participate. The goal is to see if this …

This study tests whether listening to specially designed musical patterns and receiving mild brain stimulation can improve arm and hand function in people with corticobasal syndrome, a rare brain disease that causes movement problems. Twenty adults with the condition will be spli…

This study tests whether drinking a commercially available ketone product (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in adults who already use a CPAP machine. Researchers will measure ketone levels in the blood and monitor sleep. The goal is …

This study tests a high-intensity swallowing therapy program for adults who have trouble swallowing after an ischemic stroke. Researchers want to see if this therapy helps people swallow better, eat more safely, and feel improvements in their daily life. The study will involve 60…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21–65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression sever…

This study looks at whether the Gracie Diet can reduce symptoms of gastroesophageal reflux disease (GERD) in adults who want to stop taking standard acid-reducing drugs. Thirty participants will stop their medication and follow the diet for 8 weeks. Researchers will track symptom…

This study tests whether a safe, painless brain stimulation technique called tDCS can improve verbal learning in people with typical and atypical Alzheimer's disease. About 94 participants will receive either real or sham stimulation while practicing word lists. The goal is to se…

This study tests if an injection of hyaluronidase can help reduce muscle stiffness in the arm after a stroke. About 56 people with moderate to severe arm stiffness will receive either the study drug or a placebo, and later switch to the other option. The goal is to see if the tre…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help adults with chronic PTSD who are already on antidepressants. Twenty participants will receive psilocybin, with some also getting trauma-focused talk therapy. The goal is to …

This study tests whether low-dose ketamine infusions can reduce fatigue in people with multiple sclerosis (MS). About 110 adults with MS and significant fatigue will receive either ketamine or a placebo. The goal is to see if ketamine can safely improve fatigue symptoms.

This study collects information from about 679 adults who have had a procedure called percutaneous cholangiopancreatoscopy (PCPS) to treat bile duct stones, blockages, or certain cancers. The goal is to see how well the procedure works and how many patients can have their drainag…

This study aimed to see if tartrazine, a common food dye, could temporarily make skin transparent in healthy adults. Researchers planned to apply different doses to the back, stomach, and forearm, then take photos to check transparency. The study was withdrawn before any voluntee…

This study tests whether a video camera can accurately measure vital signs like blood oxygen levels, heart rate, and blood pressure. Researchers at Johns Hopkins are recording 94 adults aged 18-75 to build a database and improve telemedicine. The goal is to make remote checkups m…

This study uses a large database of over 5 million patients to learn more about cholesterol and other blood fats. Researchers want to find patterns that could help personalize treatment for people with abnormal lipid levels. The study does not involve any new treatments or drugs—…

This study follows 80 people with Neurofibromatosis type 1 (NF1) who are at high risk for developing malignant peripheral nerve sheath tumors (MPNST). Researchers will use yearly whole-body MRI scans and blood tests to track changes in nerve tumors over time. The goal is to find …

This study looks at whether a special counseling program, called CUES, plus a safety planning app can help women living with HIV who have also experienced intimate partner violence. About 450 women from a Johns Hopkins clinic will take part. The goal is to see if this approach im…

This study follows 500 people with neurofibromatosis type 1 (NF1) to track how their skin tumors (cutaneous neurofibromas) change over five years. Researchers use 3D cameras to measure tumor growth and look at genetic factors. The goal is to better understand these tumors and hel…

This study collects blood or skin samples from 100 adults with inherited heart rhythm disorders (like Long QT Syndrome) and healthy volunteers. Researchers will turn these samples into stem cells that can become heart cells in a dish. The goal is to better understand how these di…

This study looks at whether a computer-delivered alcohol intervention plus a community health worker can help women who drink heavily and are at risk for HIV. About 12 women will take part to see if the program is practical and acceptable. The goal is to reduce alcohol use and im…

This study is creating a registry of 2000 people with GERD (chronic heartburn) and related conditions like Barrett's esophagus. Researchers will collect medical records and survey data over 5 years to better understand how these diseases are diagnosed and treated. Participants mu…

This study looks at whether placing a premature baby on their belly (prone) or back (supine) during delayed cord clamping helps them breathe better and reduces the need for a breathing tube. About 89 preterm infants will be randomly assigned to one of the two positions while stil…

This study looks at whether a comprehensive sexual education program can help prevent violence and bullying among students in rural Madagascar middle schools. About 4,500 students and their teachers in 50 schools will take surveys to measure experiences like bullying, dating viol…

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function in 15 healthy adults. Participants will take psilocybin and have their brain activity measured with EEG and TMS. The goal is to understand how psilocybin affects cognitive control…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) progresses in this group. Researchers will use a non-invasive scan to measure liver fat and stiffness over one year. No new treatments are tested; the goal is to fill knowledge gaps and g…

This study looks at Cleidocranial Dysplasia (CCD), a rare genetic condition affecting bones and teeth. Researchers will collect medical history, quality-of-life surveys, and DNA samples from 300 participants to better understand the disease and improve care. The goal is to help d…

This study looks at how to best help people with serious mental illness take part in a heart disease risk reduction program called IDEAL Goals. Researchers will compare different support methods, like coaching and extra help, to see which works best. About 72 staff from community…

This study looks at how information from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF and those without it. About 60 adults aged 40-85 will wear devices for two weeks and unde…

This study aims to find genes that cause inflammatory bowel disease (IBD) specifically in African Americans. Researchers will collect health information and blood samples from 2,400 African Americans, both with and without IBD. The goal is to better understand the genetic causes …

This study was designed to see if a new ultrasound device with a needle guide could help doctors safely insert needles into the femoral artery during a liver cancer treatment called chemoembolization. The study was withdrawn before any participants were enrolled, so no results ar…

This study looks at whether a patient navigator—a person who helps guide patients through the healthcare system—can improve timely follow-up after an abnormal breast screening mammogram. The research focuses on groups most affected by delays during the COVID-19 pandemic. About 19…

This study looks at whether being overweight makes air pollution more harmful for children with asthma. About 200 kids from Baltimore, half overweight and half at a healthy weight, will get either real or fake air purifiers in their homes. The goal is to see if cleaning the air h…

This study aims to find new antibodies in the blood that might be causing certain stomach and bowel movement disorders. Researchers will analyze blood samples from 300 people over age 13 who have ongoing gut symptoms. The goal is to better understand if the immune system is attac…

This study follows 300 patients with severe alcoholic hepatitis who receive a liver transplant before the usual 6-month sobriety period. Researchers track how many survive for one year and whether they return to drinking. The study also surveys public opinion on this practice.

This study looks at whether muscle twitching during a common neck pain treatment (radiofrequency ablation) can help predict who will get good pain relief. Researchers will grade the twitching and compare it to how much pain drops after the procedure. About 60 adults with long-ter…