Johns Hopkins University

This study tests whether omalizumab, an allergy drug, can reduce serious lung flare-ups in people with COPD who also have allergies. About 334 adults over age 40 with a history of smoking and COPD will receive the drug or a placebo for 12 months. The goal is to see if the drug lo…

This study tests a device that electrically stimulates the balance nerve to help people with severe, long-term dizziness and unsteadiness. The implant aims to improve posture, walking, and vision stability. The trial includes up to 8 adults aged 22-90 whose condition did not impr…

This study tests whether sildenafil (the drug in Viagra) can help people with scleroderma who have mildly high blood pressure in their lungs. About 30 participants will receive either sildenafil or a placebo for 4 months. The main goal is to see if they can walk farther in a 6-mi…

This study looks at whether aspirin can reduce inflammation and improve breathing in people with COPD, a serious lung disease. Researchers will test different daily doses of aspirin in 48 former smokers to find the dose that best blocks overactive blood cells linked to inflammati…

This study tests a program called Full-SPARCS, where trained peers help people with HIV stay on their medication and in care after they leave prison in South Africa. The goal is to see if this support helps keep the virus under control (viral suppression) compared to usual care. …

This study tests whether giving newborns a nasal microbiome transplant from a parent can increase the diversity of bacteria in the baby's nose. The goal is to see if this can help prevent infections like Staphylococcus aureus. The study involves 175 premature babies in the NICU a…

This study tests a program to help adolescents and young adults with HIV choose their preferred treatment, including long-acting injectable medications, and overcome barriers to getting it. The goal is to help more young people achieve viral suppression (undetectable virus levels…

This study tests whether a new ultra-high resolution CT scanner can find blocked heart arteries more accurately than a conventional CT. About 140 adults with suspected heart disease will get one scan, and the ultra-sharp images will be compared to standard-quality images made fro…

This study tests a self-administered rehabilitation tool that gently guides users to move their head more to reduce motion sickness and help balance recovery. It is for adults with motion sickness, vestibular disorders, or after certain ear surgeries. The tool aims to make sympto…

This study tests a special laser to see if it can safely improve the rough bumps and redness caused by keratosis pilaris (KP), a common but harmless skin condition. About 25 adults with KP on both upper arms will receive the laser treatment. Researchers will check results using p…

This study tests a trauma-informed digital program designed to improve health and safety for women who have experienced violence and have symptoms of PTSD or depression. Researchers will enroll 676 immigrant women aged 18 and older. The program focuses on reducing stress, depress…

This study follows 4,000 adults aged 25–35 without serious lung disease to learn what healthy lungs look like and how to spot early warning signs of chronic lung conditions. Researchers will measure lung function over time using simple breathing tests. The goal is to find ways to…

This study aims to find better ways to detect pancreas cancer early in people at high risk due to family history or genetic mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 volunteers during routine endoscopy. The goal is to identify mark…

This study tests whether a new digital tool and communication training can help doctors talk more effectively with parents about safe sleep practices for infants. Researchers will compare families whose doctors use the tool to those receiving standard care. The goal is to reduce …

This study looks at how the immune system of adults over age 75 responds to the yearly flu shot. Researchers want to know if a common virus called CMV affects how well the vaccine works. About 1,025 healthy or frail older adults will join, and they will receive the flu shot for f…

This study looks at how different forms of cannabis edibles—chocolates, gummies, and drinks—affect thinking, behavior, and blood levels. Healthy adults aged 21-55 will take part in 9 sessions, each involving an overnight stay and tests of memory, attention, and driving skills. Th…