Johns Hopkins University

This study tested a computer program featuring an avatar that guides people through quitting smoking, along with support from a community health worker who helps arrange lung cancer screening. Ten adults from low-income housing in Baltimore took part. The main goal was to see if …

This study tested whether adding evolocumab, a drug that lowers bad cholesterol, to standard care helps people who recently had a heart attack. The goal was to see if it reduces cholesterol and inflammation in the heart and blood vessels. The study involved 100 adults aged 25 to …

This study tested whether adding financial incentives to integrated care centers helps people with HIV who inject drugs or are men who have sex with men achieve viral suppression. Over 2,300 participants in India were followed to see which approach worked better. The goal was to …

This study tested whether evolocumab, a drug that lowers cholesterol, can also reduce inflammation and heart damage after a certain type of heart attack (NSTEMI). Sixty adults who had a recent heart attack received either evolocumab or a placebo. The main goals were to see change…

This study tested whether telehealth medication management could help adolescents and young adults with uncontrolled asthma take their inhaled steroids more regularly. Over 300 participants were randomly assigned to receive either standard care or telehealth coaching. The goal wa…

This study tested two strategies to treat hepatitis C in people who use drugs and are in an opioid treatment program. One group got fast treatment with a peer mentor who had been cured of HCV, while the other group got the usual referral to an outside clinic. The goal was to see …

This study tested whether vericiguat, a drug that helps blood vessels relax, could improve heart artery function in people with metabolic syndrome (a cluster of conditions like high blood pressure, high blood sugar, and excess belly fat). 45 adults took either vericiguat or a pla…

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants received a digital scale and blood pressure monitor to track their health over six mon…

This pilot study tested a program to help prevent hypoglycemia (dangerously low blood sugar) in adults with diabetes who take medications like insulin. The program was offered in a primary care clinic, and the study checked if patients and doctors found it acceptable and useful. …

This study tested a computer program called C-Raven that uses a virtual counselor to help people stop smoking. 18 adults who smoked daily took part. The program included two 20-minute iPad sessions and optional nicotine replacement therapy, plus follow-up support from a community…

This study tested new rapid HIV tests that give results during a single clinic visit, instead of waiting days. The goal was to see if these faster tests help more people start HIV treatment or prevention medicine quickly. 224 adults at high risk for HIV in Baltimore took part. Th…

This study tested whether a special video eye-tracking device (VOG) can help emergency room doctors more accurately diagnose the cause of vertigo or dizziness. 130 adults with these symptoms were randomly assigned to get either VOG-guided care or standard care. The goal was to se…

This study tested whether a specially trained nurse could help more women at risk for HIV learn about and start PrEP, a daily pill that prevents HIV. About 440 women from OB/GYN clinics took part. Some got standard care, while others also met with the nurse via video to discuss t…

This study tested a prevention program called Wakȟáŋyeža (Little Holy One) with 124 Native American caregivers and their 2-to-5-year-old children on a Northern Plains reservation. The program aims to reduce stress and trauma symptoms in caregivers, improve parenting skills, and s…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower blood sugar as well as a program with a human coach. 368 adults with prediabetes and overweight took part. The goal was to see if the digital approach is a cost-ef…

This study tested a program called Healthy for Two/Healthy for You, where health coaches called pregnant women to help them manage weight gain. The goal was to prevent too much weight gain during pregnancy, lower the risk of gestational diabetes, and reduce long-term obesity in b…

This study looked at whether special programs can help older adults become more active after a minimally invasive heart valve replacement (TAVR). Forty people who had the procedure took part. Some received motivational coaching, some did home-based exercise with coaching, and oth…

This study tested a program called CAPABLE in 268 older adults who had recently been in the hospital. The program included help with medications, strength and balance exercises, pain management, and home modifications. The goal was to see if these services could improve their abi…

This study tested a new device called Incremental Velocity Error (IVE) to see if it improves dizziness treatment better than standard therapy. 24 adults with mild traumatic brain injury or inner ear problems took part. The device aims to boost the reflex that keeps your eyes stea…

This study tested different non-surgical treatments to reduce pain and improve daily function in 1,937 adults with knee osteoarthritis. The goal was to find which treatments work best so people can avoid relying on opioids. Results help doctors choose the right treatment for each…

This study tested whether using air cleaners at home and getting support to reduce smoking could improve breathing and quality of life for people with COPD who smoke. Researchers enrolled 144 smokers with COPD and measured changes in shortness of breath and overall health. The go…

This study tested a personalized activity plan for 61 people with early-stage dementia. The goal was to see if meaningful activities could help maintain thinking skills and ease difficult symptoms. Participants worked with researchers to design activities they enjoyed, with plans…

This study looked at whether group drum classes could help people with Parkinson's or Huntington's disease feel better and move easier. Eighteen adults aged 18-89 took drum lessons twice a week for 12 weeks. Researchers checked their hand movement, mood, and overall well-being be…

This pilot study tested a program called DAPPER for African American women aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study measured changes in pain intensit…

This study tested whether suvorexant, a sleep medication, can reduce drug use and cravings while improving sleep and stress in people being treated for both opioid and stimulant use disorders. Twenty adults already stable on methadone or buprenorphine took part. The goal was to s…

This study compared two minimally invasive procedures to relieve stomach blockage caused by advanced cancer. 112 adults with severe nausea, vomiting, and inability to eat were randomly assigned to receive either an ultrasound-guided bypass or a stent placement. The goal was to se…

This study tested a small device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 46 adults with opioid use disorder stayed in a research unit for 2-3 weeks. Some got the real device, some got a fake device, and some got standard withdrawal…

This study tested a device called Gigstride in 44 adults who have trouble walking due to leg problems like arthritis, multiple sclerosis, or foot drop. The goal was to see if people liked using it and if it helped with walking speed, stairs, and balance. Participants used the dev…

This study tested a program that combines depression treatment with physical rehabilitation for people who survived acute respiratory failure in the ICU. The therapy was delivered by phone and home visits. The goal was to see if this approach is practical and might improve both m…

This study tested a program to help hospitalized people with HIV quit smoking. It used two computer sessions and a community health worker for support. The goal was to see if the program was practical and liked by patients, and if it helped them feel ready to quit. 22 adults took…

This study looked at whether a short sleep program (Brief Behavioral Therapy for Insomnia) helps people living in a residential substance use treatment center sleep better and stay in recovery longer. About 83 adults took part, wearing sleep trackers and completing surveys. Resea…

This study gathered health information from 200 children and young adults with overweight or obesity who were at risk for high blood pressure. Researchers reviewed their medical records to track heart-related data over time. The goal was to better understand how excess weight aff…

This study looked at how disrupted sleep changes the way painkillers work in the brain and whether it makes them more addictive. Healthy adults aged 18-48 with normal sleep patterns took part in experiments where their sleep was purposely broken up. Researchers measured pain reli…

This study looked at how Delta-8 THC affects people compared to Delta-9 THC and a placebo. 28 healthy adults took the substances by mouth or inhalation. Researchers measured drug effects, thinking skills, and collected blood, urine, and saliva samples to understand the difference…

This pilot study tested whether it is possible and safe to keep a person's blood pressure within a specific range during surgery to protect the brain. 27 older adults having hip, knee, or lung surgery took part. The goal was to see if this approach could reduce problems like conf…

This study tested a new imaging tracer to see if it is safe for brain scans in people with Long COVID. Six adults with a past COVID infection, some with ongoing symptoms, received the tracer and an MRI. The goal was to check safety and see if the scans could reveal brain differen…

This study tested whether a virtual group session for Spanish-speaking mothers of newborns could help them learn about postpartum depression and connect with support resources. 26 mothers participated in a single online session during a well-child visit. The goal was to see if th…

This study tested a web-based toolkit to help jails provide better care for pregnant people with opioid use disorder. Researchers worked with jail staff and pregnant individuals to see what tools and support are needed. The goal was to learn how to improve care both inside jail a…

This study looked at 27 postmenopausal women with frequent urinary tract infections (UTIs) to understand why vaginal estrogen therapy prevents UTIs in only about half of them. Researchers examined changes in vaginal and bladder bacteria and immune responses before and after treat…

This study looked at the best way to provide free fruits and vegetables to adults with overweight or obesity who also struggle to afford healthy food. 48 participants were randomly assigned to receive either weekly vouchers to buy produce or home-delivered boxes tailored to their…

This study tested a program to help staff at community mental health clinics better support their patients in quitting smoking. Researchers worked with 91 clinic staff to see if training and support could improve their knowledge and confidence in delivering evidence-based smoking…

This study looked at how endoscopic skull base surgery affects patients' sense of smell and taste, and whether a simple smell training program could help them recover faster. Researchers followed 41 adults with non-cancerous skull base tumors before and after surgery. The goal wa…

This study tested whether a virtual counselor program, combined with support from a community health worker, is acceptable and feasible for helping people in public housing quit smoking and get screened for lung cancer. Five adults aged 50 or older who smoke took part. The goal w…

This study looked at how eating dinner early versus late affects metabolism in 41 healthy adults aged 18-30. Researchers timed meals based on each person's internal body clock, measured by a hormone called melatonin. Participants ate either before or after their natural melatonin…

This study tested a two- to three-month program that teaches liver transplant candidates and a chosen 'Live Donor Champion' how to educate others and advocate for live donor liver transplantation. 76 adults on the transplant waitlist who had no potential donors at the start took …

This study looked at how tobacco-free nicotine pouches affect the body and mind compared to smoking cigarettes. 71 healthy adult smokers tried different flavors and doses of pouches, as well as their own cigarettes, in a controlled setting. Researchers measured nicotine levels in…

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over six months. The go…

This study looked at how common prescription and over-the-counter drugs influence mood and medication preference in 25 healthy adults. Participants rated how much they liked each drug and its perceived value. The goal was to gather knowledge, not to treat any condition.

This study looked at 3000 adults with pancreatic cysts to find better ways to tell which cysts might turn into cancer. Current tests are not always accurate. Researchers used imaging, fluid from the cyst, and genetic markers to improve detection. The goal is to help doctors make …

This study measured the pressure inside the chest of 37 adults with a collapsed lung (pneumothorax) during standard treatment. The goal was to see if these pressure readings could help doctors understand which patients might need more advanced procedures. The research did not tes…

This study tested whether reading short stories (vignettes) could change how much people trust their primary care doctors. Over 1,100 adults answered a survey about trust after reading different stories. The goal was to see if it's possible to influence trust, which may help redu…

This study tested a computer tool that helps doctors identify social needs—like trouble getting food or housing—in African American patients with chronic diseases such as diabetes or high blood pressure. The tool gave patients a risk score and suggested referrals to community org…