SCHIZOPHRENIA

This study is tracking 1500 adults with schizophrenia who are starting a new medication called KarXT (xanomeline and trospium chloride). Researchers want to see how well it works in everyday life, what side effects occur, and how doctors adjust the dose. The goal is to understand…

This study looks at whether maintenance electroconvulsive therapy (ECT) can help people with schizophrenia that doesn't get better with the strongest medication, clozapine. About 140 adults who improved after a course of ECT will either continue with regular ECT sessions or recei…

This study compares a new version of the long-acting schizophrenia injection paliperidone palmitate (given every 3 months) to the approved drug Invega Trinza. About 260 adults with stable schizophrenia will receive multiple doses to see if the new formulation works similarly in t…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either the drug or a placebo for 16 weeks, and researchers will track thei…

This study tests whether adding an anti-inflammatory drug to an NMDA-enhancing medication can improve thinking and memory in people with ultra-resistant schizophrenia. About 80 adults who have not responded well to clozapine will receive the combination or a placebo. The goal is …

This study tests a medicine called cariprazine in teenagers aged 13 to 17 with schizophrenia. The goal is to see if it reduces symptoms like delusions and hallucinations over 6 weeks. About 330 teens will take either the drug or a placebo. This is a phase 3 trial, meaning it's on…

This study tests a long-acting injection of cariprazine given once a month under the skin. It is for people with schizophrenia, bipolar I disorder, or major depressive disorder who are stable on other medications. The goal is to see if the injection is safe, tolerable, and effect…

This study tests whether magnetic seizure therapy (MST) can safely reduce symptoms in people with schizophrenia that hasn't improved with standard medications. About 80 adults with treatment-resistant schizophrenia or schizoaffective disorder will receive MST, which uses magnetic…

This study looks at whether the diabetes drug metformin can help prevent blood sugar problems caused by statins (cholesterol-lowering drugs) in people with schizophrenia. About 400 adults with stable schizophrenia will take either metformin or a placebo alongside their statin for…

This study tests whether valbenazine can help people with tardive dyskinesia (uncontrollable movements) who still have symptoms while taking or after stopping another drug. About 50 adults with schizophrenia, bipolar disorder, or major depression will take valbenazine for 24 week…

This study tests an experimental drug called KarXT in 166 teenagers (ages 13-17) with schizophrenia. The goal is to see if KarXT safely reduces symptoms like hallucinations and social withdrawal better than a placebo. Participants will receive either the drug or a dummy pill for …

This study checks the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and KarXT plus KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug openly for up to 2 years. T…

This study is testing a new drug called ML-007C-MA in 500 adults with schizophrenia to see if it is safe and works well over a full year. Participants either recently completed a related study or are new to the trial. The goal is to understand the long-term effects and tolerabili…

This study looks at the long-term safety of an investigational drug called KarXT when added to current antipsychotic treatment for people with schizophrenia whose symptoms are not well controlled. About 280 adults who completed a previous study will take KarXT for up to 52 weeks.…

This study tests an experimental drug called NBI-1117568 to see if it can delay the return of schizophrenia symptoms in adults who are already stable on the drug. About 560 participants will first receive the drug openly, then be randomly assigned to continue the drug or switch t…

This study tests a different way of starting olanzapine in people with schizophrenia. The goal is to see if a slower dose increase is safer and still controls symptoms. About 120 adults who have had schizophrenia for over a year will take part. The study is currently recruiting.

This study looks at how KarXT affects bladder function and overall safety in 60 adults with schizophrenia. Participants will stop their current antipsychotics and take KarXT for 12 months. The goal is to see if the drug causes any urinary problems or other side effects.

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The main goals are to see if it helps with weight management, thinking ski…

This study checks the long-term safety of an experimental drug called NBI-1117568 in 600 adults with schizophrenia. Participants must stop taking other antipsychotic medications before joining. The main goal is to track any side effects that occur during treatment.

This study tests a community-based cognitive remediation program for 160 adults with schizophrenia or schizoaffective disorder. Participants do computer exercises and group sessions to improve memory, problem-solving, and social skills. The goal is to see if this helps them think…

This study is testing a new medication called SEP-363856 in 100 adults with schizophrenia who are already stable on their current treatment. The goal is to see how safe and tolerable the drug is when taken for a full year. Participants will take either 75 mg or 100 mg daily, and …

This study tests a new medicine called LB 102 to see if it helps reduce symptoms of schizophrenia, such as hallucinations and confused thinking. About 456 adults with acute schizophrenia will receive either LB 102 or a placebo for 6 weeks. The goal is to find a safe and effective…

This study tests whether clozapine, a powerful antipsychotic, works better than risperidone for people with schizophrenia, schizoaffective disorder, or bipolar 1 disorder who have a specific brain-based 'biotype.' About 320 adults will be randomly assigned to receive either cloza…

This study tests whether a non-invasive brain stimulation technique called tDCS can help people with schizophrenia reduce their cannabis use. Researchers will give 110 participants 10 sessions of stimulation targeting brain areas linked to control and reward. The goal is to see i…

This study tests a program called Taking Action, where trained peers help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia learn to manage their condition. About 300 students will be randomly assigned to either the program or just…

This study tests whether clozapine, a medication for schizophrenia, can reduce violent acts better than standard treatments. It involves 280 adults with schizophrenia or schizoaffective disorder who have been violent in the past six months. Participants will receive either clozap…

This study explores whether some cases of schizophrenia or schizoaffective disorder are actually caused by the immune system attacking the brain. Researchers are giving an immune-suppressing drug called ocrelizumab to 40 adults aged 18-35 who developed psychosis after age 15. The…

This study tests whether a long-acting injection of iloperidone can prevent schizophrenia symptoms from getting worse compared to a placebo. About 400 adults aged 18 to 65 with schizophrenia will receive either the drug or a placebo injection and be monitored for how long it take…

This study tests a drug called KarXT in about 250 Japanese adults with schizophrenia who are currently having severe symptoms (psychosis). The goal is to see if KarXT reduces symptoms like hallucinations and delusions better than a placebo over 5 weeks, and then to check its safe…

This early-stage study tests a new oral medication, LY03020, in healthy adults and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. Up to 40 participants will receive either the drug or a placebo, and researchers will monitor…

This study is testing whether a prebiotic (a type of fiber that feeds healthy gut bacteria) can reduce inflammation and improve thinking and memory in people with schizophrenia or schizoaffective disorder. Researchers will enroll 60 adults who are stable on antipsychotic medicati…

This study tests whether people with schizophrenia can learn to quiet their auditory hallucinations using real-time brain scans (fMRI). Participants see their own brain activity and try to shift it toward a non-hallucinating state. The trial involves 84 adults whose hallucination…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia quit or reduce smoking. Fifty adults who smoke at least 5 cigarettes daily will receive active rTMS using one of two c…

This study tests whether adding acetazolamide, a drug often used for altitude sickness, can reduce symptoms in people with schizophrenia that hasn't improved with standard treatments. About 60 adults aged 18-55 will receive either acetazolamide or a placebo alongside their usual …

This study tests whether adding cromoglicate, a drug used for allergies, can improve symptoms in people with schizophrenia or schizoaffective disorder. About 160 adults aged 18-60 who are already on a stable antipsychotic medication will receive either cromoglicate or a placebo f…

This study tests whether adding a second drug that boosts brain signals can improve schizophrenia symptoms better than one drug alone. It involves 90 adults with schizophrenia who have not responded well to at least two standard antipsychotics. Participants will continue their cu…

This study tests a non-invasive brain training technique called real-time fMRI neurofeedback to help people with schizophrenia who still hear voices despite medication. Participants learn to control brain activity linked to auditory hallucinations. The goal is to reduce the inten…

This study tests a 12-session group program called "Better Together" for single young adults with severe mental illness (like schizophrenia, bipolar disorder, or major depression). The program teaches communication, emotional regulation, and healthy relationship skills. Researche…

This early-stage study is testing a long-acting injectable form of KarXT for people with schizophrenia. The main goals are to check safety and how the drug moves through the body. About 48 participants will receive a single injection, and researchers will monitor side effects and…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve cognitive problems and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's disease. Researchers will give TMS to the …

This study tests a virtual reality cognitive remediation program for people with psychotic disorders like schizophrenia. The program aims to improve thinking, social skills, and daily functioning. Researchers will enroll 52 adults aged 18-60 who are clinically stable. The main go…

This study tests an experimental drug called NBI-1117568 to see if it can improve schizophrenia symptoms better than a placebo. About 284 adults with schizophrenia who need hospital care will take the drug or a dummy pill for 5 weeks. The main goal is to measure changes in sympto…

This study is testing whether a drug that enhances NMDA receptor function can reduce negative symptoms (like lack of motivation and social withdrawal) in people with schizophrenia. Researchers want to see if the drug works differently for men and women. The study involves 90 part…

This study tests whether a low dose of buprenorphine (0.15 mg) can improve social motivation in 40 adults with schizophrenia. Social motivation problems—like low desire to connect with others—are common and have no approved treatments. Participants will receive both the drug and …

This study tests a new medication, NBI-1117570, to see if it can improve symptoms like confusion, mood changes, and unusual behavior in adults with schizophrenia who need hospital care. About 120 people aged 18 to 55 will receive either the drug or a placebo for 35 days. The goal…

This study tests whether playing a special motion-controlled video game for 2 months can improve thinking and memory in people with schizophrenia. Researchers will enroll 84 stable patients from mental health centers in Shanghai. The goal is to see if this fun, game-based approac…

This study tests a new smartphone app that uses games and stories to help people with schizophrenia improve their thinking, mood, and daily life skills. About 84 hospitalized adults will use the app for several weeks. The goal is to see if this engaging approach works better than…

This study tests an experimental drug called NBI-1117568 to see if it can improve schizophrenia symptoms like hallucinations and confusion in adults who need hospital care. About 284 participants will receive either the drug or a placebo for 5 weeks while staying in the hospital.…

This study compares a new drug, OLZ/SAM, to the standard medication olanzapine in 220 teens aged 10-17 with schizophrenia or bipolar I disorder. The goal is to see if OLZ/SAM causes less weight gain over 12 weeks and up to a year. Participants must have a reliable family member o…

This early-stage study tests a new drug called VV119 in healthy adults and people with schizophrenia. The main goal is to check safety and how the drug moves through the body. About 40 participants will take multiple doses to see if it is well-tolerated.

This study tests whether a daily synbiotic (probiotic plus fiber) supplement can reduce symptoms like hallucinations and social withdrawal in people with schizophrenia or schizoaffective disorder. About 68 adults will take either the supplement or a placebo for several weeks, whi…

This study tests a program called Motivation Skills Training (MST) to help people with schizophrenia or schizoaffective disorder improve motivation and reach personal goals. About 80 adults will be randomly assigned to either MST or a healthy behaviors group for 12-14 weeks. Rese…

This study looks at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. About 190 veterans will receive CBT and be monitored for changes in pain interference, qualit…

This study tests whether a non-invasive brain stimulation technique called high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive problems like memory and attention in people with schizophrenia. About 100 adults with stable schizophrenia will …

This study looks at whether safely stopping unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can improve thinking, daily function, and quality of life in people aged 40-70 with schizophrenia or schizoaffective disorder. Participants will be randomly assigned to …

This study tests whether a non-invasive brain stimulation technique called TMS can improve brain function and thinking in people with schizophrenia. Forty adults aged 18–60 will receive either real or sham TMS daily for four weeks, alongside their usual care. Researchers will use…

This study tests whether yoga-based exercises can improve community functioning—like social activities, work, and daily living skills—in veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder. About 112 participants will be randomly assigned to either yoga o…

This study tests whether breathing extra oxygen (normobaric oxygen therapy) can improve thinking, quality of life, and daily function in people who have had psychosis for less than 5 years. 20 participants aged 15-35 will be randomly assigned to receive oxygen or a placebo. The g…

This study tests whether a personalized form of brain stimulation, called iTBS, can help reduce symptoms of schizophrenia. Forty adults with schizophrenia will receive daily stimulation sessions for two weeks, while continuing their usual medications. Researchers will measure cha…

This study tests whether metformin, a common diabetes medication, can improve memory and thinking in people with schizophrenia. Researchers will give 120 participants either metformin or a placebo for 24 weeks and measure changes in cognitive tests and brain scans. The goal is to…

This study tests an experimental drug, emraclidine, in about 268 adults with schizophrenia. The goal is to see if it safely reduces symptoms like hallucinations and confused thinking. Participants take the drug or a placebo for up to 42 days and are monitored closely. The trial i…

This study tests whether a noninvasive brain stimulation technique called iTBS can improve working memory and brain activity in people with early-stage schizophrenia. Researchers will use magnetic pulses and EEG to measure changes in the prefrontal cortex. 75 participants aged 18…

This study tests whether MDMA (the active ingredient in ecstasy) is safe and tolerable for people with schizophrenia. The goal is to see if it can improve social motivation, a common and hard-to-treat symptom. Twenty participants will receive increasing doses of MDMA in a control…

This study tests a drug that boosts NMDA activity as a standalone treatment for schizophrenia. It is for people who refuse or cannot take standard antipsychotics due to side effects or poor response. The trial will measure changes in symptoms like hallucinations and social withdr…

This study tests whether a smartphone app called Kiso Mind is acceptable and practical for people with schizophrenia or schizoaffective disorder. About 60 participants will either use the app plus their usual care, or just usual care, for 12 weeks. The main goal is to see if peop…

This study tests a new drug, ALTO-101, given through a skin patch, to see if it helps with thinking and memory problems in people with schizophrenia. About 82 adults with stable schizophrenia and cognitive issues will receive either the drug or a placebo, then switch. The main go…

This study tests an experimental oral medication, ML-007C-MA, against a placebo in 300 adults hospitalized for a sudden worsening of schizophrenia symptoms. The goal is to see if the drug safely reduces psychosis severity, measured by a standard symptom scale. Participants must b…

This study tests a therapy called Targeted Cognitive Training (TCT) for 80 veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses computer exercises to improve how the brain processes sounds and information. Researchers will use EEG brain s…

This study tests whether BXCL501 can safely reduce agitation in children aged 10-17 with schizophrenia or bipolar disorder. Participants receive either the drug or a placebo, and researchers measure changes in agitation using a standard rating scale. The trial is currently recrui…

This study tests whether a non-invasive brain stimulation technique called navigated transcranial magnetic stimulation (nTMS) can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal, and reduced speech. Forty adults with schizophrenia will rec…

This study tests whether a new drug called GXV813 can safely reduce symptoms of schizophrenia during an acute episode. About 142 hospitalized adults aged 18-65 will receive either GXV813 or a placebo. The main goal is to see if the drug improves scores on a standard symptom scale…

This study tests a new medication called Ulotaront (SEP-363856) to see if it can safely reduce severe symptoms like hallucinations and delusions in people with schizophrenia. About 522 adults experiencing an acute psychotic episode will receive either the drug or a placebo for 6 …

This study looks at how satisfied adults with schizophrenia are with a new medication called xanomeline and trospium chloride (X/T). Researchers will ask 300 participants about their treatment preferences and reasons for any changes. The goal is to gather real-world information, …

This study uses PET scans to measure cannabinoid receptors in the brains of healthy volunteers and people with conditions like schizophrenia, cannabis dependence, PTSD, and opioid use disorder. Researchers aim to understand how these receptors differ across groups and how they ch…

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants from six clinics will either get standard care or the enhanced versio…

This study looks at how people with conditions like schizophrenia, depression, bipolar disorder, Alzheimer's, Parkinson's, stroke, or epilepsy think and make decisions. Researchers will compare their performance on computer tasks to healthy volunteers. The goal is to create a det…

This study looks at whether cognitive remediation (brain exercises with coaching) can improve thinking skills and reduce problem behaviors in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take part. Th…

This study aims to find biological markers in people with treatment-resistant schizophrenia who respond to the drug clozapine. Researchers will examine 200 participants using brain scans, blood tests, and spinal fluid analysis before and after 12 weeks of treatment. The goal is t…

This study uses powerful 7T MRI brain scans and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare 320 patients and healthy volunteers aged 18-45 to improve diagnosis …

This study looks at how attention and specific thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to those without. Participants will complete computer gambling tasks during brain scans and eye-tracki…

This study looks at tiny particles called exosomes in the blood of people having their first episode of schizophrenia. Researchers want to see if these particles carry signals that are linked to problems with memory, attention, and other thinking skills. The goal is to better und…

This study uses brain scans (MRI) to compare how the brain works in people with schizophrenia or schizoaffective disorder and healthy volunteers. Researchers aim to understand differences in brain connections and function during memory tasks. Up to 1,000 participants will provide…

This study looks at whether a fast type of brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), can improve thinking and memory in people with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. About 30 adults …

This study compares brain energy use, lactate, and glutamate levels between 75 people with schizophrenia and healthy volunteers. Participants undergo MRI and PET scans to measure brain activity and chemistry. The goal is to better understand how the brain works in schizophrenia, …

This study looks at whether a safe, non-invasive technique called transcranial direct current stimulation (tDCS) can help with attention, learning, and memory problems in people with schizophrenia. Researchers will test 160 participants to see if applying a tiny electrical curren…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different parts of the prefrontal cortex and test how it changes behavior. The goal is to understand which brain cir…

This study looks at how a part of the brain called the thalamus helps us switch between tasks and adapt to new situations. Researchers will scan the brains of 100 healthy adults using a powerful MRI machine while they complete thinking tasks. The goal is to understand why people …

This study looks at whether a non-invasive magnetic stimulation technique can improve how quickly people with psychotic disorders (like schizophrenia or bipolar disorder) solve challenging tasks. About 95 participants will do thinking exercises and get brain scans before and afte…

This study uses MRI scans to understand why people with schizophrenia hear voices that aren't there. Researchers think a small brain area called the inferior colliculi may fail to filter out internal sounds. 40 participants with schizophrenia will have their brain activity measur…

This study uses fun virtual reality games and brain wave recordings (EEG) to explore how people with schizophrenia or bipolar disorder experience time differently than healthy individuals. Researchers will measure reaction times, errors, and brain signals during tasks that involv…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like memory, attention, and decision-making—in people with various neuropsychiatric conditions. Researchers will enroll 600 adults with diagnoses such as traumatic…

This study is testing a new job training program that uses virtual reality to help people with schizophrenia improve their job interview skills. About 40 adults aged 20 to 55 who are stable and motivated to work will take part. The goal is to see if the program can boost their ab…

This study uses a safe, noninvasive brain stimulation technique called TMS to learn how hallucinations happen in people with schizophrenia or schizoaffective disorder. Researchers will measure brain activity and symptom changes in 68 participants before and after TMS. The goal is…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illness like psychosis or schizophrenia. Researchers will use surveys, daily check-ins, and brain scans to understand these connections. The goal is to…

This study looks for early signs that a person having their first psychotic episode will not get better with standard treatment. Researchers will use brain imaging to find markers that predict poor response by month 3. The goal is to identify these patients sooner so they can rec…

This study looks at whether a gentle brain stimulation technique called tDCS changes the number of connections between brain cells in people with schizophrenia. Researchers will use special PET scans to measure these connections before and after treatment. The goal is to better u…

This study is testing a new social skills training program designed to help veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) improve their work relationships and job success. About 20 veterans will take part in weekly group sessions and practic…

This study explores whether precise brain stimulation can lower cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will use a type of magnetic stimulation (rTMS) on specific brain areas and measure changes in cravings and brain activity. The g…

This study looks at language difficulties in people with psychosis, including those with schizophrenia or early warning signs. Researchers will give language tests to 90 patients and compare results with healthy controls. The goal is to understand how language problems connect wi…

This study looks at 200 children and teens (ages 7-20) who have had a psychotic episode, such as in schizophrenia. Researchers will use interviews, brain scans, and genetic tests to group participants by their symptoms. The goal is to see if these groups can predict which antipsy…

This study is testing whether a type of brain stimulation called repetitive TMS can increase natural inhibition in the brain of people with schizophrenia. Thirty-four adults with schizophrenia will receive five days of low-frequency magnetic pulses over the motor cortex. The main…

This study looks at how people with schizophrenia experience time and sensory information differently. Researchers will use a visual illusion to test if small delays in what we see disrupt the flow of time for patients. The goal is to better understand the unusual experiences tha…

This study looks at how people with schizophrenia use the passage of time to predict and prepare for a touch sensation. Researchers will measure finger movements and brain signals to find objective markers of time perception problems. The goal is to develop a test that could help…

This study looks at 320 people who recently developed psychosis (like schizophrenia or bipolar I) to see if brain scans, eye-tracking, and genetics can predict who will get better with treatment. Participants attend four visits over a year, providing DNA, EEG, and MRI data. The g…