SCHIZOPHRENIA

This study looks at whether adding cognitive behavioral therapy (a type of talk therapy) to standard medication can improve symptoms and daily functioning for people with conditions like anxiety, depression, OCD, PTSD, bipolar disorder, schizophrenia, and personality disorders. A…

This program tracks the safety of Zyprexa Relprevv, a long-acting injectable medication for schizophrenia. It monitors 4,000 patients to reduce the risk of a rare but serious side effect called post-injection delirium/sedation syndrome (PDSS). The goal is to better understand and…

This study looks at the long-term safety of a drug called OLZ/SAM in teenagers with schizophrenia or bipolar I disorder. About 236 teens who finished a previous related study can join. The main goal is to track any side effects over time.

This study tests whether giving time- and event-based cues can improve prospective memory (remembering to do things in the future) and help people with schizophrenia or schizoaffective disorder take their medication as prescribed. About 104 adults aged 18–60 with these conditions…

This study tests whether a combination of two drugs, dasatinib and quercetin, can safely slow down accelerated aging in older adults with treatment-resistant depression or schizophrenia. The drugs are known to remove aging cells from the body. The study involves 40 participants a…

This study aimed to see if a lifestyle program called Lifestyle MIND could help people with serious mental illness manage or prevent type 2 diabetes. Participants would have been randomly assigned to join the program right away or later. The study was withdrawn before any partici…

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication helps people with early schizophrenia stay on treatment longer and feel better. About 180 participants will receive either CBD or a placebo for 12 months. The goal is to see if CBD improves sym…

This study tests a behavioral therapy designed to reduce violent behavior in young adults (ages 16-30) who are in the early stages of psychosis, including schizophrenia. The therapy is given alongside their usual care. The main goals are to see if the therapy is acceptable and fe…

This study looks at whether D-serine, a natural brain chemical, can help people with schizophrenia or schizoaffective disorder learn and remember better. About 60 adults aged 18-50 will take D-serine for 16 weeks while doing a special auditory training program. The goal is to see…

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and tolerable for people with psychotic disorders like schizophrenia. About 20 adults aged 18-65 with schizophrenia, schizoaffective disorder, or early warning signs of psychosis w…

This study tests a smartphone app called CT-155 for people with schizophrenia who have negative symptoms like low motivation and lack of pleasure. About 262 adults will use the app for 16 weeks, with an option to continue for another 16 weeks, while continuing their usual treatme…

This study tests a 6-week training program for people who care for a family member with schizophrenia. The program teaches coping skills and provides support to reduce caregiver stress, improve mental well-being, and boost confidence. 66 primary caregivers will participate, and r…

This study aimed to test whether a type of brain stimulation called intermittent theta burst stimulation could reduce symptoms in people with schizophrenia that didn't improve with medication. It planned to compare real stimulation to a placebo in about 40 adults aged 18-40. Howe…

This study tests two types of talk therapy—Cognitive Enhancement Therapy and Enriched Supportive Therapy—to help adults with schizophrenia who have lasting negative symptoms like low motivation and lack of emotion. About 90 outpatients aged 18-60 will take part. The goal is to se…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal, and reduced emotional expression. About 62 adults with schizophrenia who have stable medication will recei…

This study tests whether a ketogenic (low-carb, high-fat) diet can reduce symptoms in people with schizophrenia or schizoaffective disorder. Fifty adults will be randomly assigned to either the ketogenic diet or a control diet for several weeks. Researchers will measure changes i…

This study tests whether berberine, a natural compound, can safely improve negative symptoms of schizophrenia—like lack of motivation and emotion—that current medications often miss. About 120 adults with schizophrenia will receive either berberine or a placebo for a set time. Re…

This study tests a therapy called imagery rescripting in 8 people with early psychosis. The goal is to see if it helps change negative core beliefs and improve wellbeing and self-esteem. Participants receive 4-6 therapy sessions over a few weeks and are followed for 3 more weeks.…

This study tests whether a gentle electrical current applied to the scalp (tDCS) before computer-based thinking exercises can improve memory, attention, and planning in people with schizophrenia. 120 adults will receive either real or fake stimulation over three weeks. Researcher…

This study tests whether adding mindfulness-based therapy to usual care helps people with serious mental illness (like schizophrenia, bipolar disorder, or major depression) feel better and improve their quality of life. Researchers will enroll 160 adults from a community mental h…

This study aimed to see if a sublingual film of dexmedetomidine (BXCL501) could quickly reduce agitation in adults with bipolar disorder or schizophrenia visiting the emergency department. It was a single-arm pilot study, but it was withdrawn before enrolling any participants. No…

This small pilot study tests whether adding EEG biofeedback (brain training) to virtual reality therapy can help people with schizophrenia better tolerate and reduce distressing auditory hallucinations. Thirty adults with schizophrenia who hear voices will receive either VR thera…

This study tests an experimental drug called SPG302 in 32 adults with schizophrenia to see if it can reduce symptoms like hallucinations and disorganized thinking. Participants take the drug or a placebo for a set time, and researchers measure changes in symptom severity, brain a…

This study looks at health records and insurance claims from 6,876 adults with schizophrenia who are taking the medication KarXT. Researchers want to understand who is getting the drug, how it's being prescribed, and whether people stick with it. They will also track hospital vis…

This study was designed to observe how medication affects people with schizophrenia who have committed violent crimes. Researchers planned to track changes in symptoms and aggressive behavior over time. However, the study was withdrawn before enrolling any participants, so no res…

This study tests whether a non-invasive brain stimulation technique called cTBS can change brain activity and improve thinking in people with schizophrenia or schizoaffective disorder. About 40 participants will receive the stimulation and have their brain scans and cognitive per…

This study follows 400 people with schizophrenia who took part in an earlier clinical trial. Researchers want to see how their health and daily lives change over 3 to 10 years. The goal is to learn what early factors predict future hospital stays and social functioning.

This study looks at whether adding cognitive remediation (a type of brain training) to standard early psychosis care helps young people function better in work, school, and social settings. About 117 participants from nine OnTrackNY programs will either receive usual care or usua…

This study explores whether playing soft sounds during sleep can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare sleep and memory performance in 70 participants (healthy adults and schizophrenia patients) during two naps—one…

This study looks at whether eating food changes how the body absorbs a new medicine called LY03020, which is being developed for schizophrenia and Alzheimer's-related psychosis. Sixteen healthy adults will take the drug once with food and once without, and researchers will measur…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, schizophrenia, autism, and others, as well as healthy volunteers. The goal is to compare brain structure and function across different ages, sexes, and diagnoses. By understanding ho…

This study was designed to see if a gentle brain stimulation technique called tDCS could help with negative symptoms (like lack of motivation or emotion) in people with schizophrenia. Researchers planned to use brain scans and electrical recordings to understand how it works. How…

This study tests a new program that combines executive function training with cognitive-behavioral social skills training for adults aged 60 and older with schizophrenia or schizoaffective disorder. The goal is to see if the combined approach helps improve daily living skills, su…

This study looks at how a specific brain chemical pathway (tryptophan-kynurenine) may cause thinking and memory problems in people with schizophrenia. Researchers will measure blood markers and cognitive function in 200 participants, including healthy volunteers. The goal is to c…

This study looks at how a non-invasive brain stimulation technique called paired associative stimulation (PAS) affects working memory in people with schizophrenia. Researchers will use brain scans (EEG) and memory tasks to measure changes over one week. The goal is to understand …