SCHIZOPHRENIA

This study will test the safety and effectiveness of an extended-release medication called paliperidone in 505 adults with schizophrenia in Bangladesh. Participants will take the medication for 12 weeks, and researchers will track changes in symptoms, side effects, and quality of…

This study compares a new version of a long-acting aripiprazole injection to the approved version (Abilify Maintena) in 116 adults with stable schizophrenia. Participants receive five injections over 141 days to see if the new version works the same in the body. The goal is to co…

This study tests whether a digital platform called mindLAMP can help primary care workers in India deliver better care for people with schizophrenia. About 240 adults with schizophrenia and at least one physical health risk (like diabetes or high blood pressure) will receive eith…

This early-stage study tests a single injection of AX251, a long-acting form of an existing schizophrenia medication, in 48 adults with stable schizophrenia. The goal is to measure how the drug moves through the body and check for side effects. Participants will receive one shot …

This small pilot study will test whether bromocriptine, a drug used for other conditions, is safe and tolerable for people with schizophrenia who also have prediabetes. The goal is to see if it can help manage blood sugar problems caused by antipsychotic medications. Fifteen adul…

This study tests the long-term safety of a new medication, LB-102, in 900 adults with stable schizophrenia. Participants will take the drug for 52 weeks while doctors monitor side effects and overall health. The goal is to see if LB-102 is safe for ongoing use to control schizoph…

This study looks at whether switching from daily oral antipsychotic pills to a monthly injection of paliperidone palmitate can better control schizophrenia symptoms and improve social functioning. About 120 adults with stable schizophrenia will take part. The goal is to see if th…

This study tests a personalized program combining lifestyle changes (exercise, diet, sleep, social activities), a weight-loss medication (semaglutide) for those who are overweight, and optional brain stimulation for depression. The goal is to improve mental functioning in 140 adu…

This study tests whether a shared decision-making tool helps young adults (ages 18-30) with early psychosis feel more involved in choosing their antipsychotic medication. The goal is to improve how often they attend appointments and stick with treatment. Researchers will compare …

This study tests whether a brief mobile app can help improve mood and reduce negative thinking in 100 people with schizophrenia or at clinical high risk for psychosis. Participants will use the app and report changes in defeatist beliefs and negative symptoms. The goal is to see …

This study tests an experimental drug called LY03020 in 160 adults with schizophrenia who are currently having severe symptoms (acute psychosis). Participants will receive either the drug or a placebo for a set time, and researchers will measure changes in a standard symptom scal…

This study tests whether a supplement called pyrroloquinoline quinone (PQQ) can help reduce negative symptoms (like lack of motivation) and improve thinking in people with chronic schizophrenia. About 70 adults will be randomly assigned to receive either PQQ or a placebo for seve…

This study tests whether prucalopride, a drug used for constipation, can improve thinking and memory in people with schizophrenia. 34 adults with stable schizophrenia will take the drug for 4 weeks alongside their usual medication. Researchers will measure changes in symptoms and…

This study tests whether aerobic exercise, alone or with a gentle brain stimulation technique called tDCS, can improve memory and attention in people with treatment-resistant schizophrenia. About 160 adults will take part in a 6-week program. The goal is to find a safe, drug-free…

This study tests a group program designed to help veterans with serious mental illness feel more comfortable and confident working with their healthcare teams. The goal is to improve collaboration so that care better matches each veteran's personal goals. About 119 veterans from …

This early-stage study tests whether KR23248 capsules are safe and how the body processes them in 66 healthy adults aged 18 to 45. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study does not aim to treat schizophrenia, only to …

This study will compare two groups of people with psychosis: those whose symptoms are caused by methamphetamine use and those with schizophrenia. Researchers will track 200 adults in Sohag, Egypt, using interviews and symptom scales to see how the two conditions differ in severit…

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet with a newer method using a vein tourniquet and low-dose medication. The goal is to see which met…

This study looks at how cannabis use changes both positive symptoms (like hallucinations) and negative symptoms (like lack of motivation) in people with schizophrenia. Researchers will track 120 participants in their daily lives using mobile phone surveys and thinking tasks. The …

This study will test a new mobile mental health app designed to help people with schizophrenia or schizoaffective disorder remember to take their medication. Researchers want to see if the app is easy to use and acceptable to patients. Fifty adults aged 18-60 who are in remission…

This study looks at how mental state, emotional eating, and sleep quality together influence the risk of metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) in 78 adults with schizophrenia or bipolar disorder. Researchers will measure participant…

This early-stage trial will give a single oral dose of a radioactive-labeled drug (SEP-380135) to 8 healthy men to see how it is absorbed, broken down, and eliminated. The study does not aim to treat any disease, but to gather important information for future research. Participan…

This study looks at how a community-based program called the Clubhouse Model affects thinking skills, daily life, and brain activity in adults with schizophrenia. Researchers will compare it to standard outpatient care. Thirty participants will complete interviews, thinking tests…

This study looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. Researchers will use brain scans and cognitive tests to build models that could help diagnose these conditions and predict treatment …

This study tests whether a structured medication education program helps psychiatric inpatients with schizophrenia, bipolar disorder, or psychotic depression take their medications as prescribed and manage side effects. Researchers will enroll 64 adults in a psychiatric clinic an…