Sound waves may spot schizophrenia early: new study
NCT ID NCT07604129
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a non-invasive brain ultrasound, combined with machine learning, can help distinguish people with schizophrenia from healthy individuals. Researchers will scan 200 adults (100 with schizophrenia, 100 without) and measure specific brain features. The goal is to build a computer model that could one day aid doctors in earlier diagnosis, though it will not replace standard psychiatric evaluation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial sonography (brain ultrasound)
- What this could lead to
- If successful, this could give doctors a new, non-invasive tool to help diagnose schizophrenia earlier, especially in unclear cases.
- What could go wrong
- This is an early-stage study with only 200 participants. The model is a research tool and won't replace a psychiatrist's diagnosis. It may not work well in broader populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adults aged 18 to 65 years will be recruited from Taizhou Second People's Hospital and related recruitment channels. The study population will include participants with schizophrenia diagnosed according to ICD-10 criteria and healthy control participants without a personal or family history of psychiatric disorders. Healthy controls will be matched as far as possible to the schizophrenia group by basic demographic characteristics. All participants will undergo baseline transcranial sonography assessment and clinical data collection.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Schizophrenia group: 1. Adults aged 18 to 65 years. 2. Diagnosis of schizophrenia according to ICD-10 criteria by a psychiatrist. 3. Able to complete clinical assessment and transcranial sonography examination. 4. No other severe physical disease, neurological disease, or major psychiatric disorder. 5. Written informed consent provided by the participant or legally authorized representative. Healthy control group: 1. Adults aged 18 to 65 years. 2. No personal history of psychiatric disorders. 3. No family history of psychiatric disorders. 4. No severe physical disease, neurological disease, or major psychiatric disorder. 5. Basic demographic characteristics matched as far as possible to the schizophrenia group. 6. Able to complete clinical assessment and transcranial sonography examination. 7. Written informed consent provided by the participant or legally authorized representative. Exclusion Criteria: 1. Severe physical disease or neurological disease. 2. History of drug or alcohol abuse. 3. Inability to complete clinical assessment or transcranial sonography examination. 4. Inadequate temporal acoustic window or poor image quality preventing valid transcranial sonography measurements. 5. Acute or clinically unstable state that prevents completion of study procedures. 6. Comorbid major psychiatric disorder, such as major depressive disorder. 7. Refusal or withdrawal of informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Taizhou Second People's Hospital
Taizhou, Zhejiang, 317200, China
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Other studies related to the condition(s) this trial covers.
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