Cannabis and schizophrenia: a Real-World look at the dual effects
NCT ID NCT07309159
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will follow 120 people with schizophrenia who use cannabis, using mobile phone surveys and thinking tasks to track symptoms in real time. The goal is to understand how cannabis may both worsen positive symptoms (like hallucinations) and reduce negative symptoms (like lack of motivation). The findings could help shape better care for patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cannabis
- What this could lead to
- If successful, this study could clarify how cannabis affects schizophrenia symptoms, potentially guiding better management strategies.
- What could go wrong
- This is an early-phase observational study, not a treatment trial. Results may not lead to direct clinical changes, and cannabis use carries known risks for mental health.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * DSM-5 diagnosis of schizophrenia or schizo-affective disorder with the following clinical features: * Clinically stable and in the residual (non-acute) phase of illness, * No change in antipsychotic treatment for at least 1 month, * Outpatient, ambulatory care, * No uncontrolled positive symptoms (assessed using PANSS) * Patients able to use a mobile phone. * Capacity and willingness to give informed consent. * Must be able to read, speak, and understand French * Patients subscribing to the French national medical insurance. * Patients under "curatelle" (partial guardianship) are eligible Exclusion Criteria: Patient under "tutelle" (full legal guardianship). * Psychiatric comorbidities: autism, bipolar disorder. * Current criteria for any other substance use disorder except for nicotine use disorder. * Any medical condition hindering the study and/or use of the smartphone application. * Patients with somatic, cognitive or other disorders preventing the use of the device (deafness, impaired vision, illiteracy….). * Pregnant or breastfeeding woman. * Patients who are not proficient in French. * Subject included in clinical and/or therapeutic experimentation in progress.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.
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