PANCREATIC DUCTAL ADENOCARCINOMA

This study tests two experimental drugs, elironrasib and daraxonrasib, alone or together, in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to see if the drugs are safe and can shrink or control the cancer. About 534 adults wit…

This study tests a new daily pill, VS-7375, for people with advanced cancers (like pancreatic, lung, or colorectal) that have a specific KRAS G12D mutation. The trial will check if the drug is safe and shrinks tumors when used alone or with other treatments. About 295 adults will…

This early-phase study tests a new radioactive drug, [177Lu]Lu-NNS309, in adults with advanced pancreatic, lung, breast, or colorectal cancers that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shr…

This study tests a more thorough surgery technique called total mesopancreas excision for people with pancreatic head cancer. The goal is to remove more of the tissue around the tumor to lower the chance of cancer coming back. 90 adults with resectable cancer will be followed for…

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors that have not responded to standard treatments. The main goal is to check the drug's safety. About 10 adults with cancers like liver, lung, or melanoma will take part.

This study tests a new approach for people with advanced pancreatic cancer that cannot be removed by surgery. It combines a procedure that uses heat to destroy tumor cells (radiofrequency ablation) with an immunotherapy drug (pembrolizumab) and standard chemotherapy. The goal is …

This early-phase trial tests a new treatment called iExosomes for people with metastatic pancreatic cancer that has a specific KRAS G12D mutation. The therapy uses tiny particles (exosomes) to deliver a molecule that silences the cancer-driving gene. The study aims to find the sa…

This study tests an experimental drug called PF-08046050 in people with advanced solid tumors (cancers that have spread or can't be removed). The drug is designed to stick to cancer cells and kill them. The main goal is to check safety and find the right dose. About 914 adults wi…

This early-phase study tests a new drug called DR-0202 in about 96 people with advanced solid tumors (like breast, lung, or pancreatic cancer) that have not responded to at least two prior treatments. The main goal is to check the drug's safety and find the right dose. Participan…

This study tests an experimental oral drug called IPN01194 in 220 adults with advanced solid tumours (melanoma, colorectal, pancreatic, or head and neck cancers) that have spread and no longer respond to standard treatments. The goal is to find the right dose and check if the dru…

This study tests an experimental drug called ART0380 in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with other chemotherapy drugs (gemcitabine or irinotecan). About 442 adults with certai…

This study tests a new way of giving chemotherapy to people with metastatic pancreatic cancer. Instead of using one drug combination, patients will receive two different standard chemotherapy regimens (NALIRIFOX and GnP) in alternating months. The goal is to see if this approach …

This early study tests whether fecal microbial transplants (healthy stool from donors) are safe and can help control pancreatic cancer. Ten patients scheduled for tumor-removal surgery will receive the transplant. The goal is to see if changing gut bacteria can improve outcomes.

This study tests a two-drug immunotherapy (odetiglucan and mitazalimab) as a maintenance treatment for people with advanced pancreatic cancer that has not worsened after initial chemotherapy. The goal is to see if this combination can delay cancer growth for at least 7.5 months. …

This study tests an experimental drug called AZD4360 in adults with advanced solid tumors, including stomach, gastroesophageal junction, bile duct, and pancreatic cancers that have not responded to prior treatments. The main goals are to find a safe dose and check if the drug can…

This study tests a new treatment that delivers a powerful, short-range radioactive particle directly to cancer cells that have a protein called FAP on their surface. The therapy is given in two steps: first a low-dose imaging version to see if the tumor takes up the drug, then a …

This study aims to see if MRI scans can find tiny liver tumors in people with pancreatic cancer that standard CT scans often miss. About 120 adults with newly diagnosed pancreatic cancer will get both a CT and an MRI. If MRI proves better at detecting these hidden metastases, it …

This study aims to improve early detection of pancreatic cancer by following 20,000 people who have a family history of the disease or carry certain gene changes that raise their risk. Participants will be monitored over time to see who develops cancer. The goal is to learn how t…

This study follows 4,000 adults with pancreatic cysts to learn which ones turn into cancer. Many cysts are harmless, but some may be early signs of cancer. By tracking changes over time, researchers hope to reduce unnecessary surgeries and better identify when treatment is needed…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can tell doctors within weeks if chemotherapy is shrinking a patient's metastatic pancreatic cancer, instead of waiting the usual 8 weeks for a scan. About 50 people with newly diagnosed, advanced pancrea…

This study enrolls 5,000 people at high risk for pancreatic cancer to collect blood, pancreatic juice, and medical images over 10 years. Researchers will use this information to develop and test new methods for early detection, including AI-assisted analysis. Participants must be…

This study looks at whether genetic information from tumors can help doctors choose better treatments for pancreatic cancer. About 200 adults with certain types of pancreatic cancer will give blood, tissue, and fluid samples for genetic testing while receiving standard chemothera…

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The main goal is to see how RAD301 moves through the body and how much radiation reaches orga…