PANCREATIC DUCTAL ADENOCARCINOMA

This study tests whether adding cisplatin to the standard two-drug chemo (nab-paclitaxel and gemcitabine) works better for people with metastatic pancreatic cancer who have BRCA1/2 or PALB2 gene mutations. The trial aims to see if the three-drug combo shrinks tumors more and help…

This phase 2 trial tests a new drug called ZN-c3 combined with the chemotherapy gemcitabine in 12 people with advanced pancreatic cancer that has worsened after platinum-based treatment. The goal is to see if the combination is safe and can slow cancer growth. Participants take Z…

This phase IIb trial tests whether adding ATRA (a vitamin A derivative) to standard chemotherapy can help people with locally advanced pancreatic cancer live longer without their disease getting worse. About 170 participants will receive either the combo or chemo alone. The study…

This early-phase trial tests an investigational drug called ABBV-400 in about 300 adults with advanced solid tumors, including liver, pancreatic, breast, and ovarian cancers. The study aims to see if the drug can shrink tumors and to check for side effects. Participants receive A…

This study was designed to see if giving two chemotherapy drugs (gemcitabine and capecitabine) after surgery could help people with pancreatic cancer stay cancer-free longer. It was for patients who had already received chemotherapy before surgery. However, the trial was withdraw…

This phase II trial tests whether switching from one chemotherapy combination (mFOLFIRINOX) to another (gemcitabine/nab-paclitaxel) early in treatment can help shrink pancreatic tumors enough for successful surgery. The study includes 42 adults with pancreatic cancer that is eith…

This study tests a new drug called chiauranib combined with two standard chemotherapy drugs as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination can help control the cancer and improve survival. …

This study tests whether adding the experimental drug navlimetostat to standard chemotherapy can help people with a specific type of advanced pancreatic cancer (one with an MTAP gene deletion) live longer or slow tumor growth. About 470 adults who have not had prior treatment for…

This study tests an experimental pill called IPN01194 in adults with advanced solid tumors (melanoma, colorectal, pancreatic, or head and neck cancers) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 36 …

This study tests a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) for people with inoperable pancreatic cancer. The goal is to see if using a heat probe to destroy tumor tissue can help patients live longer compared to standard medical care alone.…

This early-phase study tests a new drug called JANX008 in about 130 adults with advanced solid tumors, including lung, kidney, head and neck, colorectal, pancreatic, and breast cancers. The main goal is to check safety and find the right dose. Participants must have tried all sta…

This phase 2 trial is testing the safety and effectiveness of glipizide, a standard diabetes drug, for lowering blood sugar in people with pancreatic cancer. The study includes 29 participants with active pancreatic cancer and high blood sugar. Researchers will measure blood suga…

This early-stage trial tests a new drug called BMS-986484, alone or with another drug (nivolumab), in people with advanced solid tumors like lung, colon, pancreatic, stomach, and head/neck cancers. The main goal is to check safety and find the right dose. About 213 participants w…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced solid tumors that have spread or cannot be removed by surgery. The cancers include certain types of breast, lung, and pancreatic cancer. The goal is to see if the combination can shrink t…

This study tests if washing the abdomen with distilled water or saline right after removing a pancreatic tumor can help patients live longer. About 845 adults having surgery for pancreatic or related cancers are randomly assigned to one of three groups: washing with saltwater, wa…

This early-stage study tests an experimental drug called SGN-MesoC2 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to attach to cancer cells and kill them. The study aims to find a safe dose and check for side effects in …

This study tests different combinations of immunotherapy drugs given before and after surgery for people with pancreatic cancer that can be removed. The goal is to see if these treatments can help the immune system fight the cancer better and improve outcomes. About 76 participan…

This study tests whether giving a single dose of chemotherapy directly into the liver artery, before standard treatment, is safe and feasible for people with localized pancreatic cancer. It includes 20 adults whose cancer can be surgically removed. The goal is to see if this adde…

This early-phase study tests a new drug called LY4066434 in people with advanced solid tumors that have certain KRAS mutations. The main goal is to see if the drug is safe and tolerable when given alone or with other treatments. About 750 participants with pancreatic, lung, or co…

This early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, a…

This early-phase trial tests whether adding the drug ivosidenib to standard chemotherapy can help shrink pancreatic tumors before surgery. About 16 people with resectable pancreatic cancer will take part. The main goal is to find the safest dose and see how well the combination w…

This study tests whether giving chemotherapy both before and after surgery helps people with pancreatic cancer live longer compared to chemotherapy only after surgery. About 378 patients with resectable pancreatic cancer will be randomly assigned to one of two treatment schedules…

This early-phase study tests a combination of two targeted drugs (vismodegib and erlotinib) with or without a standard chemotherapy drug (gemcitabine) in people with advanced pancreatic cancer or other solid tumors that cannot be removed by surgery. The main goal is to find the s…

This study tests a new medicine called raludotatug deruxtecan in about 160 adults with advanced gastrointestinal cancers (pancreatic, bile duct, gallbladder, colorectal, stomach, or gastroesophageal junction). The drug is designed to attach to cancer cells and deliver a treatment…

This study tests a combination of two experimental drugs (AGEN1423 and botensilimab) with or without standard chemotherapy in people with advanced pancreatic cancer that has worsened after at least one prior treatment. The goal is to see if the combination can shrink tumors or sl…

This early-phase trial tests an experimental immunotherapy called ELI-002 7P in people with pancreatic or other solid tumors that have specific KRAS or NRAS gene mutations. The treatment aims to train the immune system to attack cancer cells. About 158 participants will receive t…

This early-stage study tests a new drug (RO7496353) combined with an immunotherapy (checkpoint inhibitor) and sometimes chemotherapy in people with advanced lung, stomach, or pancreatic cancer. The main goal is to check safety and find the right dose. About 102 participants will …

This early-phase study tested a vaccine therapy given directly into the tumor along with a growth factor to boost the immune system in 18 people with advanced pancreatic cancer that could not be removed by surgery. The main goal was to find the safest dose and check for side effe…

This study tests whether a combination of three drugs (paricalcitol, hydroxychloroquine, and losartan) can safely modify the supportive tissue around pancreatic tumors before surgery. About 20 adults with resectable pancreatic cancer will take these drugs for at least 4 weeks bet…

This early-phase trial tests whether transferring healthy gut bacteria from donor stool can help control pancreatic cancer. Ten patients scheduled for tumor-removal surgery will receive the transplant to see if it is safe and affects the disease. The study is currently suspended.

This study tests a new drug (AZD0171) combined with two other treatments (durvalumab and chemotherapy) in people with advanced pancreatic cancer that has spread. The goal is to see if the combination is safe and helps control the cancer longer. About 126 participants will receive…

This study tests a new immunotherapy for adults with advanced pancreatic cancer. The treatment uses a special protein and virus to help the immune system kill cancer cells, combined with an antibody called ezabenlimab. The goal is to find a safe dose and see if the combination ca…

This study tests an 8-week program of nutrition, exercise, and mental support for people with pancreatic or esophageal cancer before they have surgery. The goal is to see if this program helps patients complete their planned treatments. The study includes 9 participants and focus…

This early study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. Cancer cells need lots of cholesterol to grow, and this approach aims to starve them. The trial inc…

This study aimed to test a new type of PET scan that uses two substances to find cancer cells with a marker called CA19-9. It was designed for people with pancreatic, bladder, or other gastrointestinal cancers. However, the study was withdrawn before any participants were enrolle…

This study is working on a new way to detect pancreatic cancer early using a simple urine and blood test. Researchers are collecting samples from 3500 people, both with and without pancreatic disease, to see if a panel of biomarkers can accurately identify cancer. The goal is to …

This study tests whether a program of physical activity and nutrition counseling can help people with pancreatic cysts reduce their risk of developing pancreatic cancer. Twenty-four participants will use a Fitbit to track exercise and receive diet advice over six months. The main…

This study looks at whether ketorolac, a common anti-inflammatory drug, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (severe weight loss). About 28 participants will take the drug four times daily for fi…

This registry collects information from 2000 people who have had pancreatic surgery for benign or malignant tumors. Researchers track complications and long-term results to understand what works best. The goal is to improve quality of care and support future research.

This study collects blood samples from about 100 people with non-small cell lung cancer, colorectal cancer, or pancreatic cancer who are receiving standard treatments. Researchers will measure cancer DNA levels in the blood over time and compare them to tumor changes. The goal is…

This study is creating a large database of people at high risk for pancreatic cancer, including those with cysts, genetic conditions, or other risk factors. The goal is to track their health over time to find better ways to detect the disease early or even prevent it. About 317 p…

This study tests whether a new PET imaging tracer called 18F-FAC can show how much standard chemotherapy gets into pancreatic tumors. About 30 adults with pancreatic cancer will get a PET scan before starting treatment. The goal is to gather information, not to treat the disease …

This study is building a database of information from 600 people who have a BRCA or PALB2 gene mutation and pancreatic cancer, along with their close relatives. The goal is to collect medical data and biological samples to help researchers better understand why pancreatic cancer …