PANCREATIC DUCTAL ADENOCARCINOMA

This early-phase trial tests whether adding the targeted drug ivosidenib to standard chemotherapy can help shrink pancreatic tumors before surgery. About 16 people with resectable pancreatic cancer will take part. The main goal is to find the safest dose and see how well the comb…

This study tests a new drug called LY4066434 in people with advanced solid tumors that have certain KRAS mutations. The main goal is to see if the drug is safe and tolerable when given alone or with other treatments. About 750 participants with pancreatic, lung, or colorectal can…

This study tests whether combining the experimental drug ZN-c3 with the chemotherapy gemcitabine can help control advanced pancreatic cancer that has worsened after initial treatment. The trial includes 12 adults whose cancer is not curable with standard therapies. Researchers ar…

This early-phase study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. The idea is that cancer cells need lots of cholesterol to grow, and cutting off their supply …

This study tests a new drug combination (AGEN1423 and botensilimab) with or without chemotherapy in people with advanced pancreatic cancer that has worsened after at least one prior treatment. The goal is to see if the combination can shrink tumors or slow the disease. About 24 a…

This early-stage study tests a new drug, PF-08046052/SGN-EGFRd2, in people with advanced solid tumors that cannot be removed or have spread. The main goal is to check safety and side effects, and to find the right dose. About 68 participants with colorectal, lung, head and neck, …

This study tested a combination of two drugs, cediranib and olaparib, in 122 people with advanced or spreading solid tumors, including certain breast, lung, and pancreatic cancers. The goal was to see if the combo could shrink tumors by blocking enzymes that help cancer grow and …

This study looks at how safe and effective the diabetes drug glipizide is for lowering high blood sugar in people with pancreatic cancer. About 29 adults with active pancreatic cancer and high blood sugar will take glipizide, and researchers will track their glucose levels before…

This study tests an experimental immunotherapy called ELI-002 7P in people with pancreatic or other solid tumors that have certain KRAS or NRAS gene mutations. The treatment aims to help the immune system fight cancer cells. The trial involves about 158 participants and is in ear…

This study is testing whether an 8-week program of nutrition, exercise, and mental support before surgery can help people with pancreatic or esophageal cancer. The program includes personalized physical activity, diet check-ins, and psychological care if needed. The goal is to se…

This early-phase study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (unintended weight loss). About 28 partici…

This early-phase study tests whether a special PET scan using an experimental tracer called 18F-FAC can show how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 adults with pancreatic cancer will receive the tracer before starting tre…