OSTEOARTHRITIS

This study compared four types of knee replacements in 218 people with knee arthritis. The goal was to see which design helped patients 'forget' they had an artificial joint, meaning it felt more natural. Participants were randomly assigned to one of the four knee implants and fo…

This study tested whether a single injection of stem cells taken from a patient's own belly fat could help with mild to moderate knee osteoarthritis that hasn't improved with other treatments. About 100 adults received either a low dose, a high dose, or a placebo injection. The m…

This study looked at a new type of hip implant (POLARSTEM) that doesn't use cement. It included 218 people with osteoarthritis who needed a hip replacement. Researchers checked how well the implant worked and how long it lasted over 10 years.

This study compared two different knee replacement implants (Vanguard Cruciate Retaining and AGC Total Condylar) in 150 people with knee arthritis. The goal was to see which implant provides better pain relief and function after surgery. Participants were followed for several yea…

This study tested an experimental drug called LNA043, given as injections into the knee, to see if it can help regrow cartilage in people with knee cartilage damage or osteoarthritis. The trial involved 142 adults and used MRI scans to measure changes in cartilage quality and vol…

This study tested a treatment called Chondron, which uses a patient's own cartilage cells grown in a lab and then implanted into the knee. The goal was to see if it safely reduces pain and improves knee function in people with cartilage defects from osteoarthritis or injury. Ten …

This study tested a treatment called CHONDRON for people with cartilage damage in their knees. The treatment uses a person's own cartilage cells grown in a lab and then implanted into the knee. The goal was to see if it could reduce pain and improve knee function over 48 weeks. 2…

This early-stage study tested whether an experimental drug called CYT-108 is safe for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, and were monitored for 26 weeks. The main goal was to check…

This study tested a new injection treatment for wrist osteoarthritis in 12 adults who had not improved with standard care. The treatment uses a mixture of the patient's own fat cells and platelet-rich plasma, injected into the wrist joint. The goal was to see if this approach is …

This study tested whether using vancomycin powder and a diluted iodine wash during surgery can prevent serious infections after hip or knee replacement in high-risk patients. Over 2,100 adults with conditions like obesity or smoking history took part. The goal was to see if these…

This study tested whether an experimental drug called RTX-GRT7039, given as a shot into the knee joint, can reduce pain in people with knee osteoarthritis. 469 adults who still had pain despite standard treatments took part. The main goal was to measure pain changes over 12 weeks…

This study looked at two different pain relief methods for people having knee replacement surgery. The goal was to see which method helps patients recover better and feel less pain after the operation. Sixty adults took part, and the researchers measured pain levels and overall r…

This study tested whether a single injection of type I collagen into the knee joint can reduce pain in people with knee problems like arthritis or cartilage damage. 200 adults with moderate to severe knee pain received either the collagen injection or a placebo. The main goal was…

This study tested whether injecting a gel called polyacrylamide hydrogel into the knee can reduce pain and improve daily function in people with knee osteoarthritis. A total of 387 patients (593 knees) were treated across three medical centers. Pain and function were measured bef…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, or lupus. Participants received coaching over the phone to help them walk more and manage symptoms. The goal was to see if this approach could reduce pain and …

This study tested an experimental injection called RTX-GRT7039 in 714 adults with moderate to severe knee osteoarthritis pain that wasn't helped by standard treatments. The goal was to see if the injection is safe and tolerable. Researchers measured side effects and changes in pa…

This study looked at whether a nasal spray containing oxytocin, a natural hormone, can help reduce pain and improve daily function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the oxytocin spray or a placebo. The main goal was to measure cha…

This early-stage study tested a single injection of a new drug (SAR446959) in 32 people aged 45-65 with knee osteoarthritis. The main goal was to check safety and how the drug moves in the body, not to measure pain relief. Participants were monitored for about 6 months after the …

This study looked at 351 people with knee arthritis and a torn meniscus to see if surgery or physical therapy works better. The main goal was to measure how well each treatment improved daily function and pain over 6 months. Results help guide patients and doctors in choosing the…

This early-phase study tested APPA-1, a combination of two natural compounds, in 40 healthy volunteers and people with osteoarthritis. The main goal was to check safety and how the body processes the drug. Researchers also looked at whether food or gender affects drug levels. Thi…

This study tested whether a new pill combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. 123 participants took the new combo or an existing drug combo daily for 60 days. Researchers measured pain intensity and joint s…

This early study tested whether a special injection made from a patient's own blood (called A2MRP) is safe and can help with knee osteoarthritis pain. Twenty adults with moderate knee arthritis received the injection. The main goal was to check for side effects, and researchers a…

This study tested a procedure called Subchondroplasty (SCP) done with arthroscopy versus arthroscopy alone for people with knee pain from bone marrow lesions. About 131 adults aged 30-75 with mild to moderate knee osteoarthritis took part. The goal was to see if SCP plus arthrosc…

This study tested a device that gently stimulates a nerve in the ear to see if it can reduce pain and inflammation in people with a severe type of hand arthritis called erosive hand osteoarthritis. 148 adults with painful, swollen finger joints used either an active or a sham (fa…

This study tested whether a daily plant protein supplement (Nutrilite All-Plant Protein Booster) could improve muscle function and joint pain in people aged 50–70 with mild to moderate sarcopenia (muscle loss) and osteoarthritis (joint wear). Over 12 weeks, 139 participants took …

This study tested whether injecting a mix of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) works better than either alone for temporomandibular joint (TMJ) osteoarthritis. 42 adults with TMJ arthritis received one of three injection types. Researchers measured pain le…

This study tested a single injection of RTX-GRT7039 in 466 adults with knee osteoarthritis pain that wasn't helped by standard treatments. The goal was to see if it reduces pain better than a placebo injection. Researchers measured pain changes at 12 and 26 weeks using a standard…

This study looked at whether a type of muscle strengthening called eccentric exercise can improve walking in people with knee osteoarthritis. Researchers compared it to standard concentric exercise in 40 adults aged 40-85. The main goal was to see how far participants could walk …

This study tested a single injection of EVI-01 in 120 adults with painful knee osteoarthritis. Participants received one of two doses or a standard treatment to see which worked best for easing pain and stiffness. The goal was to find the safest and most effective dose for sympto…

This study followed 260 people who received a Medacta GMK Sphere knee replacement for osteoarthritis. The main goal was to see how well the artificial knee feels like a natural part of the body, using a "Forgotten Knee Score" at 2 and 5 years after surgery. Researchers also measu…

This study looked at whether a genicular nerve block (an injection near the knee nerves) can reduce pain and improve quality of life and joint position sense in people with chronic knee osteoarthritis. Forty adults aged 55-75 with moderate knee osteoarthritis took part. The goal …

This study tested whether an 8-week mindfulness program (MBSR) can reduce pain and improve daily function in 40 adults with hip or knee osteoarthritis. Participants were randomly assigned to either the mindfulness program or usual care. The main goal was to see if mindfulness tra…

This study looked at whether hip precautions (special movement restrictions) after hip replacement surgery actually prevent the hip from dislocating. Over 1,100 patients were followed for six weeks after surgery. The goal was to see if these precautions make a difference in dislo…

This study looked at whether taking daily vitamin D or fish oil supplements could reduce the risk of autoimmune diseases, lower inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or heart disease took part. Researchers measured inflamma…

This study followed 432 people who had ACL reconstruction surgery to see who later developed knee arthritis. Researchers looked at knee function, injury details, and patient traits 2 and 10 years after surgery. The goal was to identify risk factors for osteoarthritis, not to test…

This study followed 225 people who had ACL knee surgery to see what factors lead to arthritis years later. Researchers checked knee structure, pain, and quality of life at 2 and 10 years after surgery. The goal is to understand why some patients develop arthritis and others do no…

This study looked at 120 adults over 40 who had knee replacement surgery for osteoarthritis. Researchers compared four different types of knee implants to see how they affected walking, stair climbing, strength, and balance over two years. The goal was to learn which implant lead…

This study looked at 44 adults with osteoarthritis who completed a 3-week spa therapy program. Researchers used heart ultrasounds before and after treatment to see if the therapy changed heart function. The goal was to gather information, not to treat the disease.

This study analyzed health records from nearly 1 million Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers looked at changes in doctor visits, tests, and treatments before and du…

This study tested a short training for rheumatologists to help them focus on each patient's individual needs, aiming to reduce unconscious bias. Researchers looked at whether this training improved the quality of care for Black and lower-income patients with conditions like lupus…

This study looked at how bone density around the hip implant changes one year after surgery. It compared two types of implant stems (AMIStem and Quadra) in 40 adults who had a total hip replacement through a small front incision. The goal was to see if the bone remodeling was sim…

This study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned standard facts about the disease, while the other learned about how the brain and nerves process pain. Researchers measured whether the newer approach changed the body…

This study aimed to create simple self-assessment questionnaires for the shoulder, knee, and ankle. Researchers collected answers from 150 people who had already requested an orthopedic visit for that joint. They analyzed which questions best predicted the need for a specialist, …

This study looked at over 288,000 people with hip or knee osteoarthritis to learn what factors affect their long-term health. Researchers tracked who eventually needed joint replacement surgery and examined how things like education, income, and other health problems played a rol…

This study looked at how mind-body exercise (like yoga or tai chi) compares to a wellness education program in changing gut bacteria in people with osteoarthritis. 72 adults aged 55 and older with knee or hip arthritis took part. The goal was to gather information for a larger fu…

This study followed 300 people with hand osteoarthritis for up to 8 years. Researchers used exams, imaging, and surveys to track pain, inflammation, and joint changes. The goal was to learn how the disease progresses and what factors predict outcomes, not to test a new treatment.

This study tested whether changes in pupil size can reliably measure acute pain. Researchers gave short, painful heat pulses to 20 adults with hip or knee arthritis and measured how their pupils reacted. The goal was to see if pupil response could be a trustworthy, objective pain…

This study looked at how well people with ankle arthritis functioned after surgery. Researchers followed 368 patients for up to 12 years, using surveys and walking tests to measure their progress. The goal was to understand which surgical approaches lead to better long-term outco…